Diazepam (CID 3016) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(216)
 
 
Inactive(239)
 
 
Inconclusive(62)
 
 
Unspecified(2200)
 
 
Top Targets:
Neur chan LBD(127)
 
 
 
 
7TM GPCR Srx(22)
 
 
 
7TM GPCR Srsx(14)
 
 
 
 
ALBUMIN(9)
 
 
 
 
Bcl-2 like(9)
 
 
BioAssay Types:
Literature(910)
 
 
 
 
 
Screening(103)
 
 
 
Confirmatory(96)
 
 
 
BioActivity Types:
IC50(215)
 
 
 
 
 
Ki(107)
 
 
 
Potency(63)
 
 
 
EC50(19)
 
 
 
 
Kd(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2716    Data Row: 2717   Total Pages: 55   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164353]
Ki 0.0018Inhibition of [3H]diazepam binding to GABA-A central benzodiazepine receptor of rat brain homogenate [AID40969, Type: Literature]
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2
[SID103164353]
Ki 0.0021Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells [AID220448, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
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3
[SID103164353]
Ki 0.0021Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells [AID220448, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
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4
[SID103164353]
Ki 0.0021Binding affinity for mutant rat GABA-A receptor alpha-6-(his,thr,gly,val)beta2gama2 subunits expressed in HEK293 cells [AID220448, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
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5
[SID103164353]
Ki 0.0029Inhibition of [3H]diazepam binding to GABA-A central benzodiazepine receptor of rat brain homogenate [AID40968, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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6
[SID103164353]
Ki 0.0029In vitro binding affinity against benzodiazepine receptor using [3H]diazepam as radioligand [AID40970, Type: Literature]
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7
[SID103164353]
IC50 0.004Displacement of [3H]diazepam from GABA-A Benzodiazepine receptor of rat forebrain [AID42335, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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8
[SID103164353]
IC50 0.0044Displacement of [3H]flunitrazepam from GABA-A Benzodiazepine receptors in rat forebrain [AID40513, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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9
[SID103164353]
Ki 0.0049Inhibition of [3H]flunitrazepam binding to GABA-A receptor of rat cortical membranes [AID72136, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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10
[SID103164353]
Ki 0.0049Binding affinity against benzodiazepine receptor (BzR) in rat cortical membranes determined by competition experiments with radiolabeled [3H]flunitrazepam (Fnz) [AID39930, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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11
[SID103164353]
Ki 0.0049Displacement of [3H]flunitrazepam from GABA-A benzodiazepine receptor of rat cortical membranes [AID39931, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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12
[SID103164353]
Ki 0.0049Displacement of [3H]flunitrazepam from GABA-A benzodiazepine receptor of rat cortical membranes [AID40671, Type: Literature]
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13
[SID103164353]
IC50 0.0049In vitro inhibitory against Gamma-aminobutyric acid A receptor from rat cerebral cortex using [3H]flunitrazepam as the radioligand [AID72297, Type: Literature]
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14
[SID103164353]
IC50 0.0049In vitro affinity for BZD site on GABA-A receptor from rat cerebral cortex using radioligand [3H]flunitrazepam [AID72585, Type: Literature]
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15
[SID103164353]
Ki 0.005In vitro inhibition of [3H]diazepam binding to benzodiazepine receptor in rat cerebral cortical membrane [AID40666, Type: Literature]
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16
[SID103164353]
IC50 0.005In vitro displacement of [3H]diazepam from GABA-A benzodiazepine receptor [AID40830, Type: Literature]
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17
[SID103164353]
IC50 0.005Displacement of [3H]diazepam from benzodiazepine receptor in rat cerebral cortex membrane [AID401477, Type: other]
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18
[SID103164353]
Ki 0.005Displacement of [3H]diazepam from rat cerebral cortex benzodiazepine receptor [AID39938, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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19
[SID103164353]
IC50 0.005In vitro inhibition of binding to GABA-A central benzodiazepine-receptor of rat brain [AID40997, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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20
[SID103164353]
IC50 0.005Anxiolytic activity by displacement of [3H]diazepam from GABA-A receptor in rat synaptosomal membranes [AID181673, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-1 [gi:120782]
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21
[SID103164353]
Ki 0.00502Displacement of [3H]-diazepam from GABA-A benzodiazepine receptor of rat cerebral cortex [AID40966, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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22
[SID103164353]
Ki 0.00502Displacing potential to [3H]diazepam binding to benzodiazepine receptor in Wistar rat cerebral cortex [AID40503, Type: Literature]
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23
[SID103164353]
Ki 0.00502Binding affinity against benzodiazepine (BZ) receptor by displacing [3H]diazepam in cerebral cortex of Wistar rats [AID40967, Type: Literature]
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24
[SID103164353]
IC50 0.0054Binding affinity measured by [3H]diazepam binding assay in rat [AID40822, Type: Literature]
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25
[SID103164353]
IC50 0.0054Displacement of [3H]diazepam binding in rat brain membranes [AID40823, Type: Literature]
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26
[SID103164353]
IC50 0.0054In vitro inhibition of [3H]diazepam binding to rat GABA-A benzodiazepine receptor [AID40831, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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27
[SID103164353]
IC50 0.0056Binding affinity against central benzodiazepine receptor(CBR). [AID42333, Type: Literature]
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28
[SID103164353]
IC50 0.006Inhibitory concentration against specific binding of [3H]diazepam to Benzodiazepine receptor in rat brain [AID40521, Type: Literature]
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29
[SID103164353]
IC50 0.006In vitro for inhibition of [3H]diazepam towards Benzodiazepine receptor from rat [AID40661, Type: Literature]
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30
[SID103164353]
IC50 0.006Inhibition of specific binding of 1.5 nM [3H]diazepam to rat brain benzodiazepine receptors [AID40519, Type: Literature]
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31
[SID103164353]
IC50 0.006In vitro inhibitory concentration of compound against benzodiazepine receptor from rat cerebral cortex using [3H]- flunitrazepam was evaluated [AID40241, Type: Literature]
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32
[SID103164353]
IC50 0.006Concentration that inhibits binding of 1.5 nM [3H]diazepam to rat brain benzodiazepine receptor [AID40230, Type: Literature]
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33
[SID103164353]
IC50 0.006In vitro inhibition of binding to the benzodiazepine receptor in rat cerebral cortical membrane using [3H]diazepam as radioligand [AID40832, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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34
[SID103164353]
Ki 0.006Displacement of [3H]- flunitrazepam from rat GABA-A benzodiazepine receptor [AID40373, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
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35
[SID103164353]
IC50 0.006Inhibition of [3H]flunitrazepam binding to GABA-A benzodiazepine receptor of rat cerebral cortex [AID40231, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
View
36
[SID103164353]
IC50 0.006Effect on [3H]flunitrazepam binding to Benzodiazepine receptor [AID40236, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
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37
[SID103164353]
IC50 0.006Effect on [3H]flunitrazepam binding to Benzodiazepine receptor [AID40236, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
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38
[SID103164353]
IC50 0.006Effect on [3H]flunitrazepam binding to Benzodiazepine receptor [AID40236, Type: Literature]Gamma-aminobutyric acid receptor subunit gamma-2 [gi:120788]
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39
[SID103164353]
Ki 0.0066Binding affinity for Diazepam-Sensitive fraction of GABA-A benzodiazepine receptors [AID40381, Type: Literature]
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40
[SID103164353]
Ki 0.0066Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombinant human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 expressed in L(tk-)cells [AID73077, Type: Literature]
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41
[SID103164353]
Ki 0.0066Inhibition of [3H]Ro-151788 binding to recombinant human gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 subtype expressed in L (tk-) cells [AID239563, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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42
[SID103164353]
Ki 0.0066Displacement of [3H]-Ro15-1788 from human recombinant GABAA alpha2 in combination with beta3gamma2 expressed in L(tk-) cells [AID259130, Type: Literature]Gamma-aminobutyric acid receptor subunit beta-3 [gi:120773]
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43
[SID103164353]
Ki 0.0068Displacement of [3H]flunitrazepam from benzodiazepine receptor in rat neuronal membranes at 10 uM [AID294268, Type: Literature]
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44
[SID103164353]
Ki 0.0068Binding affinity to Wistar rat benzodiazepine receptor [AID261133, Type: Literature]Gamma-aminobutyric acid receptor subunit pi [gi:3023821]
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45
[SID103164353]
IC50 0.007Inhibition of [3H]diazepam binding to GABA-A benzodiazepine receptor of rat brain [AID40826, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
View
46
[SID103164353]
IC50 0.007Displacement of [3H]diazepam from rat brain GABA-A benzodiazepine receptor [AID40817, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
View
47
[SID103164353]
IC50 0.007Displacement of [3H]flunitrazepam from benzodiazepine receptor of rat cerebral cortex membranes [AID40228, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
View
48
[SID103164353]
IC50 0.0073Inhibition of [3H]flunitrazepam binding to GABA-A benzodiazepine receptor of rat cortex [AID42340, Type: Literature]Gamma-aminobutyric acid receptor subunit alpha-2 [gi:120758]
View
49
[SID103164353]
Ki 0.0078Displacement of [3H]-Ro-15-1788 from rat GABA-A receptor alpha-2-beta-2-gamma-2 subunits expressed in HEK293 cells [AID71235, Type: Literature]
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50
[SID103164353]
IC50 0.0081In vitro displacement of [3H]-diazepam from GABA-A Benzodiazepine receptor [AID40974, Type: Literature]
View