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vicriviroc (CID 3009355) - Compound BioActivity Data
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BioActivity Outcomes:
Active(20)
 
 
Inactive(5)
 
 
Inconclusive(5)
 
 
Unspecified(94)
 
 
Top Targets:
Glutaminase(1)
 
 
HpcH HpaI(1)
 
 
Firefly Luc l..(1)
 
 
BioAssay Types:
Literature(114)
 
 
 
 
Confirmatory(9)
 
 
 
BioActivity Types:
EC50(11)
 
 
 
 
IC50(6)
 
 
Potency(5)
 
 
Ki(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 124    Data Row: 124   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103281592]
IC50 0.00023Antiviral activity against HIV-1 BaL infected in PHA-stimulated human PBMC cells assessed as viral p24 core protein level after 7 days by ELISA [AID581321, Type: confirmatory]
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2
[SID103281592]
EC50 0.00037Antiviral activity against HIV1 JRCSF infected in human PBMC assessed as inhibition of viral p24 antigen production after 7 to 10 days by ELISA [AID559939, Type: Literature]
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3
[SID103281592]
IC50 0.00045Binding affinity to CCR5 [AID707904, Type: Literature]
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4
[SID103281592]
IC50 0.00046Compound was tested for inhibiting the entry of replication deffective HIV-1 (YU-2) in to U-80 cells [AID213881, Type: Literature]
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5
[SID103281592]
IC50 0.00056Antiviral activity against HIV-1 ADA infected in PHA-stimulated human PBMC cells assessed as viral p24 core protein level after 7 days by ELISA [AID581320, Type: confirmatory]
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6
[SID103281592]
EC50 0.0012Antiviral activity against HIV1 R5 infected in human PBMC assessed as inhibition of viral p24 antigen production after 7 to 10 days by ELISA [AID559940, Type: Literature]
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7
[SID103281592]
IC50 0.0012Antagonist activity at CCR5 in IL-10 stimulated human PBMC cells assessed as MIP-1beta induced chemotaxis [AID581319, Type: confirmatory]C-C chemokine receptor type 5 [gi:1705896]
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8
[SID103281592]
EC50 0.0014Antiviral activity against R5 tropic HIV1 JR-CSF in PM1/CCR5 cells assessed as protection from virus-induced cytopathogenicity measuring capsid p24 level after 5 days by ELISA [AID644281, Type: Literature]
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9
[SID103281592]
Ki 0.0025Antagonistic activity against C-C chemokine receptor type 5 [AID42503, Type: Literature]
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10
[SID103281592]
IC50 0.003Displacement of [125I]MIP-1beta from CCR5 in IL-10-stimulated human monocytes [AID581318, Type: confirmatory]C-C chemokine receptor type 5 [gi:1705896]
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11
[SID103281592]
EC50 0.026Antiviral activity against R5 tropic HIV1 NL(AD8) in PM1/CCR5 cells assessed as protection from virus-induced cytopathogenicity after 5 days by MTT assay [AID644280, Type: Literature]
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12
[SID103281592]
EC50 0.55Antiviral activity against R5-tropic HIV1 NL(AD8) infected in human PM1 cells expressing CCR5 assessed as protection from virus-induced cytopathogenicity [AID662536, Type: Literature]
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13
[SID103281592]
Compound was tested for the inhibition of HIV-1 301657 clinical isolate in PBMC cultures [AID155469, Type: Literature]
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14
[SID103281592]
Compound was tested for the inhibition of HIV-1 ADA-M clinical isolate in PBMC cultures [AID155470, Type: Literature]
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15
[SID103281592]
Compound was tested for the inhibition of HIV-1 JV1083 clinical isolate in PBMC cultures [AID155471, Type: Literature]
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16
[SID103281592]
Compound was tested for the inhibition of HIV-1 JrFL clinical isolate in PBMC cultures [AID155472, Type: Literature]
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17
[SID103281592]
Compound was tested for the inhibition of HIV-1 RU 570 clinical isolate in PBMC cultures [AID155473, Type: Literature]
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18
[SID103281592]
Antiviral activity against maraviroc-resistant HIV1 isolate CC185 at 100 times IC90 concentration [AID554061, Type: Literature]
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19
[SID103281592]
Antiviral activity against maraviroc-resistant HIV1 isolate CC185 at 10 times IC90 concentration [AID554062, Type: Literature]
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20
[SID103281592]
Antiviral activity against maraviroc-resistant HIV1 isolate CC185 at IC90 concentration [AID554063, Type: Literature]
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