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SMR000068595 (CID 2999254) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(818)
 
 
Inconclusive(11)
 
 
Unspecified(3)
 
 
Top Targets:
7tm 4(48)
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
PTPc(9)
 
 
BioAssay Types:
Screening(546)
 
 
 
 
 
Confirmatory(261)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(168)
 
 
 
 
IC50(51)
 
 
EC50(12)
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 765    Data Row: 837   Total Pages: 42   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID134959011]
AC50_uM 0.209HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_Dose_DryPowder_Activity_Set9 [AID623880, Type: confirmatory]scavenger receptor class B member 1 isoform 1 [Mus musculus] [gi:14389423]
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2
[SID134959011]
AC50_uM 0.252HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_Dose_DryPowder_Activity_Set10 [AID624029, Type: confirmatory]scavenger receptor class B member 1 isoform 1 [Mus musculus] [gi:14389423]
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3
[SID134959011]
AbsAC40_uM 0.772HDL Orthogonal Assay: Alexa 488-HDL Measured in Cell-Based System Using Plate Reader - 2085-03_Inhibitor_Dose_DryPowder_Activity_Set3 [AID624024, Type: confirmatory]
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4
[SID3715533]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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5
[SID3715533]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 2 Wildtype [AID1531, Type: screening]mitogen-activated protein kinase kinase kinase kinase 2 [Homo sapiens] [gi:22035600]
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6
[SID3715533]
Potency Activators of T cell receptors: qHTS campaign [AID504894, Type: confirmatory]T cell receptor, partial [Homo sapiens] [gi:553160]
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7
[SID3715533]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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8
[SID3715533]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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9
[SID3715533]
Potency 11.2202qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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10
[SID3715533]
Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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11
[SID3715533]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B. [AID951, Type: screening]Bcl-2-like protein 10 [gi:23396469]
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12
[SID3715533]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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13
[SID3715533]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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14
[SID3715533]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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15
[SID3715533]
qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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16
[SID3715533]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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17
[SID3715533]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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18
[SID3715533]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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19
[SID3715533]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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20
[SID3715533]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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