Bookmark and Share
SMR000063625 (CID 2998797) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(87)
 
 
Inactive(768)
 
 
Inconclusive(24)
 
 
Unspecified(12)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Death TRAILR..(12)
 
 
 
 
BioAssay Types:
Screening(590)
 
 
 
 
 
Confirmatory(276)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(171)
 
 
 
 
 
IC50(56)
 
 
 
 
EC50(18)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 813    Data Row: 891   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID3714425]
IC50 0.05247Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID624395, Type: confirmatory]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View
2
[SID3714425]
EC50 0.1Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
View
3
[SID3714425]
Potency 0.151qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
4
[SID3714425]
EC50 0.322Luminescence Cell-Based HTS Dose Confimation to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID2454, Type: confirmatory]
View
5
[SID3714425]
EC50 0.325Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
View
6
[SID3714425]
EC50 0.9Luminescence Cell-Based Dose Response to Identify Inhibitors of Luciferase Translation or Activity in H4-C Neuroglioblastoma Cells [AID2458, Type: confirmatory]
View
7
[SID3714425]
Potency 1qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
8
[SID3714425]
Potency 2.5918qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
View
9
[SID3714425]
EC50 3.301Luminescence Cell-Based Dose Response to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4-C Neuroglioblastoma Cells [AID2452, Type: confirmatory]
View
10
[SID3714425]
Potency 3.9811qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
11
[SID3714425]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
View
12
[SID3714425]
IC50 6.902Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
View
13
[SID3714425]
Potency 7.0795VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
14
[SID3714425]
Potency 7.9433qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
View
15
[SID3714425]
EC50 8.041Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
View
16
[SID3714425]
Potency 12.5893Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
View
17
[SID3714425]
IC50_PEG-3_Mean 14.9Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167, Type: confirmatory]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
View
18
[SID3714425]
IC50_PEG-3_Mean Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_4, Type: confirmatory]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
View
19
[SID3714425]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
View
20
[SID3714425]
Single concentration confirmation of uHTS hits for Peg3 Promoter Inhibitors via a luciferase reporter assay [AID602417, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
View
21
[SID3714425]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
22
[SID3714425]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
23
[SID3714425]
Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
24
[SID3714425]
Luminescence-based confirmation biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1846, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
25
[SID3714425]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
View
26
[SID3714425]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) [AID588354, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
View
27
[SID3714425]
Luminescence-based cell-based high throughput confirmation assay for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1). [AID588820, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
View
28
[SID3714425]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) [AID588352, Type: screening]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
View
29
[SID3714425]
Luminescence-based cell-based high throughput confirmation assay for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) [AID588792, Type: screening]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
View
30
[SID3714425]
uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
31
[SID3714425]
Single concentration confirmation of uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID651580, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
View
32
[SID3714425]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
33
[SID3714425]
Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID651615, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View
34
[SID87336963]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 2 (SRC2; NCOA2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID652007, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View
35
[SID87336963]
Counterscreen for antagonists of COUP-TFII (NR2F2): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID687007, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View
36
[SID3714425]
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
37
[SID3714425]
Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
38
[SID3714425]
Single concentration validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651994, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
39
[SID3714425]
Single concentration confirmation of uHTS Gli-SUFU antagonist hits in a Wnt3a luminescent reporter assay [AID651995, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
40
[SID3714425]
EC50 Luminescent HTS for small molecule inhibitors of MT1-MMP transcription [AID618, Type: confirmatory]matrix metalloproteinase 1 [Homo sapiens] [gi:6690534]
View
41
[SID3714425]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID588794, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View
42
[SID3714425]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). [AID588824, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View
43
[SID3714425]
Primary HTS and Confirmation Assays for S1P1 Agonists and Agonism Potentiators [AID449, Type: screening]sphingosine 1-phosphate receptor 1 [Homo sapiens] [gi:13027636]
View
44
[SID3714425]
Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Potentiator Assay 60K MLSMR [AID466, Type: confirmatory]sphingosine 1-phosphate receptor 1 [Homo sapiens] [gi:13027636]
View
45
[SID3714425]
Dose Response Assays for S1P1 Agonists and Agonism Potentiators - Agonist Assay 60K MLSMR [AID468, Type: confirmatory]sphingosine 1-phosphate receptor 1 [Homo sapiens] [gi:13027636]
View
46
[SID3714425]
Primary cell-based high throughput screening assay to measure STAT3 inhibition [AID862, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
47
[SID87336963]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
View
48
[SID87336963]
Luminescence-based cell-based high throughput confirmation assay to identify inhibitors of COUP-TFII (NR2F2) [AID687008, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
View
49
[SID3714425]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
View
50
[SID3714425]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
View