MLS000053249 (CID 2998122) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(26)
 
 
Inactive(707)
 
 
Inconclusive(24)
 
 
Unspecified(10)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
alkPPc(18)
 
 
Death TRAILR..(12)
 
 
 
 
Bcl-2 like(11)
 
 
7TM GPCR Srsx(10)
 
 
BioAssay Types:
Screening(511)
 
 
 
 
 
Confirmatory(233)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(151)
 
 
 
 
 
IC50(45)
 
 
 
EC50(15)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 757    Data Row: 767   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID3712684]
EC50 0.487Luminescence Cell-Based Dose Response HTS to Identify Activators of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID2002, Type: confirmatory]
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2
[SID3712684]
Potency 1.5849qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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3
[SID3712684]
Potency 2.2387qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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4
[SID3712684]
Potency 2.6855qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID3712684]
Potency 3.2563qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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6
[SID3712684]
EC50 4.215Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1999, Type: confirmatory]
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7
[SID3712684]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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8
[SID3712684]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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9
[SID3712684]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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10
[SID3712684]
Potency 5.0119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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11
[SID3712684]
Potency 6.3096qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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12
[SID3712684]
Potency 6.3096qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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13
[SID3712684]
Potency 6.3096qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
View
14
[SID3712684]
Potency 6.3096qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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15
[SID3712684]
Potency 6.3096qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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16
[SID3712684]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
17
[SID3712684]
 Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID675, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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18
[SID3712684]
 Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID675, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
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19
[SID3712684]
 Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID675, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
View
20
[SID3712684]
 Counterscreen for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1): A cell-based dose-response assay for inhibition of the RAR-related orphan receptor A (RORA) [AID675, Type: confirmatory]Nuclear receptor ROR-alpha [gi:548814]
View
21
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
22
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
23
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
24
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
25
[SID3712684]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
26
[SID3712684]
 uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
27
[SID3712684]
 uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells [AID1443, Type: screening]tumor necrosis factor ligand superfamily member 10 isoform 1 [Homo sapiens] [gi:4507593]
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28
[SID3712684]
IC50 uHTS absorbance assay for the identification of compounds that inhibit PHOSPHO1 [AID1565, Type: confirmatory]phosphoethanolamine/phosphocholine phosphatase isoform 1 [Homo sapiens] [gi:219689097]
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29
[SID3712684]
 uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
View
30
[SID3712684]
 uHTS identification of APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID493011, Type: screening]APOBEC3A gene product [Homo sapiens] [gi:21955158]
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31
[SID3712684]
 Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
View
32
[SID3712684]
 Identification of compounds which are cytotoxic to PPC-1 cells. [AID1447, Type: screening]
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33
[SID3712684]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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34
[SID3712684]
 Pyruvate Kinase [AID361, Type: confirmatory]pyruvate kinase [Geobacillus stearothermophilus] [gi:285623]
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35
[SID3712684]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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36
[SID3712684]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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37
[SID3712684]
 Dose-response cell-based assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID692, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
38
[SID3712684]
 Dose-response cell-based assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID692, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
39
[SID3712684]
 Dose-response cell-based assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID692, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
40
[SID3712684]
 Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
41
[SID3712684]
 Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
42
[SID3712684]
 Primary Cell-based High Throughput Screening assay for activators of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID522, Type: screening]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
43
[SID3712684]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
View
44
[SID3712684]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
View
45
[SID3712684]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
View
46
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
47
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
48
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
49
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View
50
[SID3712684]
 Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_4, Type: screening]TNFRSF10B gene product [Homo sapiens] [gi:224494019]
View