vanillyl-N-nonylamide (CID 2998) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(21)
 
 
Inactive(670)
 
 
Inconclusive(34)
 
 
Unspecified(16)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
p450(12)
 
 
 
 
 
NR LBD TR(8)
 
 
ANK(8)
 
 
 
HELICc(8)
 
 
 
BioAssay Types:
Confirmatory(341)
 
 
 
 
 
Screening(281)
 
 
 
Literature(89)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(303)
 
 
 
 
 
IC50(11)
 
 
EC50(7)
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 574    Data Row: 741   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103277238]
EC50 0.223Agonist activity at rat TRPV1 expressed in CHO cells assessed as calcium uptake [AID672973, Type: Literature]
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2
[SID103277238]
EC50 0.4In vitro effective dose for contraction of guinea pig ileum [AID73731, Type: Literature]
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3
[SID103277238]
EC50 0.4In vitro contraction in guinea pig ileum equivalent to 50% capsaicin response [AID73895, Type: Literature]
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4
[SID103277238]
EC50 0.55In vitro effective concentration for [Ca2+] uptake and accumulation of [Ca2+] in neonatal rat cultured spinal sensory neurons [AID175843, Type: Literature]
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5
[SID103277238]
EC50 0.55In vitro effective concentration for Ca++ uptake into dorsal root ganglia neurones in culture [AID175846, Type: Literature]
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6
[SID103277238]
EC50 0.55Effective concentration for [Ca2+] uptake into dorsal root ganglia neurones in rat cultured spinal sensory neurones [AID175668, Type: Literature]Transient receptor potential cation channel subfamily V member 4 [gi:62901120]
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7
[SID103277238]
Ki 1.223Displacement of [3H]RTX from rat TRPV1 expressed in CHO cells [AID672972, Type: Literature]
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8
[SID11111961]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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9
[SID11111961]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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10
[SID11111961]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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11
[SID11111961]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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12
[SID11111961]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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13
[SID11111961]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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14
[SID26747691]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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15
[SID26747691]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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16
[SID26747691]
Potency 25.1189qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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17
[SID11111961]
Potency 25.1189qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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18
[SID11111961]
Potency 25.1189qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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19
[SID11111961]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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20
[SID11111961]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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21
[SID11111961]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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22
[SID11111961]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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23
[SID11111961]
 Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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24
[SID11111961]
 Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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25
[SID11111961]
 Cytochrome panel assay with activity outcomes [AID1851_3, Type: other]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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26
[SID11111961]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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27
[SID11111961]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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28
[SID56463512]
 Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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29
[SID103277238]
 Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay [AID521220, Type: Literature]
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30
[SID103277238]
 Reversal activity against vanilloid receptor 1 (TRPV1) [AID218464, Type: Literature]
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31
[SID56463512]
 HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1 [AID540275, Type: screening]TRPV1 gene product [Homo sapiens] [gi:74315350]
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32
[SID56463512]
 HTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1 [AID540275, Type: screening]TRPV1 gene product [Homo sapiens] [gi:74315350]
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33
[SID56463512]
 Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of AddAB recombination protein complex [AID435030, Type: screening]hypothetical protein HP1089 [Helicobacter pylori 26695] [gi:15645703]
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34
[SID56463512]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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35
[SID103277238]
EC50 0.55Calcium +2 uptake into Dorsal Root Ganglion(DRG) neurons [AID65834, Type: Literature]
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36
[SID103277238]
 Minimum dose of iv injection that shows vagus reflex and a heart rate decrease of 50 beats/min in non-vagotomized rats [AID192646, Type: Literature]
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37
[SID50107151]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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38
[SID104171264]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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39
[SID103277238]
 In vivo analgesic activity, mouse tail flick latency in antinociceptive assay [AID130358, Type: Literature]
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40
[SID103277238]
 In vivo analgesic dose in mouse tail flick latency model [AID130359, Type: Literature]
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41
[SID103277238]
 Percentage inhibition in mouse by using Croton oil-inflamed mouse ear test (topical dosing). [AID133086, Type: Literature]
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42
[SID103277238]
 Latency time measured by mouse hot plate test after subcutaneous administration at 200 mg/kg [AID135417, Type: Literature]
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43
[SID103277238]
 Acute toxicity after intraperitoneal dose at 8 mg/kg in mice [AID135436, Type: Literature]
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44
[SID103277238]
 Ratio of the number of responders to the number of animals tested; 8/8 [AID137447, Type: Literature]
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45
[SID103277238]
 Change in blood pressure was tested by inducing ia injection at a dose 0.01 mg/kg in rat [AID171637, Type: Literature]
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46
[SID103277238]
 Percentage analgesia by rat hot plate test after oral administration at 300 mg/kg. [AID172633, Type: Literature]
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47
[SID26753670]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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48
[SID26753670]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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49
[SID11111961]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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50
[SID11111961]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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