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Chlordecone (CID 299) - Compound BioActivity Data
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BioActivity Outcomes:
Active(330)
 
 
Inactive(577)
 
 
Inconclusive(380)
 
 
Unspecified(10)
 
 
Top Targets:
NR LBD PPAR(31)
 
 
 
 
NR LBD ER(21)
 
 
 
NR LBD AR(20)
 
 
 
 
NR LBD TR(18)
 
 
 
 
7TM GPCR Srx(18)
 
 
 
BioAssay Types:
Confirmatory(568)
 
 
 
 
 
Screening(304)
 
 
 
Summary(48)
 
 
 
 
Literature(13)
 
 
 
 
BioActivity Types:
Potency(515)
 
 
 
 
 
IC50(10)
 
 
 
AC50(2)
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 635    Data Row: 1297   Total Pages: 26   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103589666]
Kd 0.49Displacement of [3H]-estradiol (E2) frrom sheep uterine estrogen receptor [AID69702, Type: Literature]Estrogen receptor [gi:1706709]
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2
[SID103589666]
Kd 0.49Displacement of [3H]-estradiol (E2) frrom sheep uterine estrogen receptor [AID69702, Type: Literature]Estrogen receptor beta [gi:13124234]
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3
[SID144208790]
Potency-Replicate_1 0.536qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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4
[SID144210418]
Potency-Replicate_1 0.5853qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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5
[SID144208790]
Ratio Potency (uM) 0.905569qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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6
[SID144210418]
Ratio Potency (uM) 1.00162qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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7
[SID144208790]
Potency-Replicate_1 1.9017qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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8
[SID56462801]
AC50_uM 2.685HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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9
[SID56462801]
AC50_uM 2.93Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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10
[SID17388955]
Potency 3.3491qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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11
[SID144208790]
Potency-Replicate_1 3.3818qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID17388955]
Potency 4.2163qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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13
[SID56462801]
Potency 4.4668qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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14
[SID144208790]
Ratio Potency (uM) 6.2983qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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15
[SID144208790]
Potency-Replicate_1 6.8043qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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16
[SID17388955]
Potency 7.9433qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID56462801]
CC50 8.692Cytotoxicity screening for potential Inhibitors of Bacterial Capsule Biogenesis [AID493020, Type: confirmatory]
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18
[SID17388955]
Potency 9.4392qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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19
[SID17389843]
Potency 9.4392qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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20
[SID144208790]
Potency-Replicate_1 9.5311qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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21
[SID144208790]
Potency-Replicate_1 9.5311qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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22
[SID144208790]
Potency-Replicate_1 9.5311qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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23
[SID17388955]
Potency 10qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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24
[SID144210418]
Ratio Potency (uM) 10.4081qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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25
[SID17389843]
Potency 10.5909qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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26
[SID17389843]
Potency 10.5909qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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27
[SID144210418]
Potency-Replicate_1 11.6781qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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28
[SID103589666]
IC50 12.0226Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881) [AID255211, Type: Literature]
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29
[SID144210418]
Potency-Replicate_1 13.103qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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30
[SID144208790]
Potency-Replicate_1 13.4631qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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31
[SID144210418]
Potency-Replicate_1 14.7018qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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32
[SID17389843]
Potency 15.8489MultiTox-Fluor Cytotoxicity Assay - LYMP1-002 - Dead Cells [AID960, Type: confirmatory]
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33
[SID17389843]
Potency 15.8489qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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34
[SID26752871]
Potency-Replicate_1 15.8489qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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35
[SID56462801]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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36
[SID56462801]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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37
[SID144208790]
Ratio Potency (uM) 16.949qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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38
[SID17388955]
Potency 17.7828qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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39
[SID56462801]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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40
[SID144210418]
Ratio Potency (uM) 18.6905qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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41
[SID144208790]
Potency-Replicate_1 19.0171qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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42
[SID17388955]
Potency 19.9526MultiTox-Fluor Cytotoxicity Assay - LYMP1-002 - Dead Cells [AID960, Type: confirmatory]
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43
[SID85148750]
CC50 22.626A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
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44
[SID144210418]
Potency-Replicate_1 23.515qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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45
[SID144208790]
Potency-Replicate_1 24.1424qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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46
[SID144208790]
Potency-Replicate_1 24.1424qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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47
[SID17388955]
Potency 25.1189Cell Viability - LYMP1-003 - Assay at 40 hr [AID964, Type: confirmatory]
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48
[SID17388955]
Potency 25.1189Cell Viability - LYMP1-002 - Assay at 40 hr [AID994, Type: confirmatory]
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49
[SID17388955]
Potency-Replicate_1 26.6032qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway - cell viability counter screen [AID720652, Type: confirmatory]
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50
[SID144208790]
Potency-Replicate_1 26.8623qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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