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CHEMBL599255 (CID 2977478) - Compound BioActivity Data
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BioActivity Outcomes:
Active(81)
 
 
Inactive(660)
 
 
Inconclusive(44)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(17)
 
 
 
Bcl-2 like(13)
 
 
 
Toxin trans(11)
 
 
 
 
alkPPc(10)
 
 
BioAssay Types:
Screening(500)
 
 
 
 
Confirmatory(247)
 
 
 
 
 
Literature(26)
 
 
 
 
BioActivity Types:
Potency(168)
 
 
 
 
 
IC50(51)
 
 
 
 
EC50(19)
 
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 701    Data Row: 794   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24796752]
Potency 0.3162qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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2
[SID24796752]
EC50 0.348Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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3
[SID103722922]
IC50 0.5Inhibition of Clostridium botulinum toxin BoNT/A light chain [AID458662, Type: Literature]Botulinum neurotoxin type A [gi:399133]
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4
[SID24796752]
Absolute IC50 0.51Dose Response Confirmation for Mcl-1/Bid Interaction Inhibitors [AID1418, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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5
[SID24796752]
EC50 0.93Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole [AID2423, Type: confirmatory]heat shock protein 90 [Candida albicans] [gi:994798]
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6
[SID24796752]
Potency 1.2589qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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7
[SID24796752]
AC50_uM 1.498Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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8
[SID103722922]
IC50 1.6Inhibition of protease activity of recombinant Clostridium botulinum BoNT/A (1 to 425) light chain after 5 mins by HPLC-based assay [AID582465, Type: Literature]Botulinum neurotoxin type A [gi:399133]
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9
[SID103722922]
IC50 2.1Inhibition of protease activity of recombinant full-length Clostridium botulinum BoNT/A light chain after 5 mins by HPLC-based assay [AID582464, Type: Literature]Botulinum neurotoxin type A [gi:399133]
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10
[SID103722922]
IC50 2.1Inhibition of Clostridium botulinum Hall BoNT/A protease activity using Ac-SNKTRIDEANQRATKML-NH2 as substrate after 5 mins by RP-HPLC analysis [AID673914, Type: Literature]
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11
[SID24796752]
AC50_uM 2.681HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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12
[SID124898773]
Potency 2.8184qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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13
[SID24796752]
IC50 3.34878Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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14
[SID24796752]
AC50_uM 3.603Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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15
[SID24796752]
Potency 4.7444qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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16
[SID24796752]
IC50 5.532QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10. [AID743254, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
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17
[SID24796752]
Potency 5.6234qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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18
[SID24796752]
Potency 6.3096qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay [AID743286, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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19
[SID124898773]
Potency 7.0795qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen [AID602199, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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20
[SID24796752]
AC50_uM 7.328ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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