Deferoxamine (CID 2973) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(30)
 
 
Inactive(247)
 
 
Inconclusive(10)
 
 
Unspecified(169)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
7TM GPCR Srsx(5)
 
 
Transferrin(3)
 
 
BRLZ(3)
 
 
 
CD36(2)
 
 
BioAssay Types:
Literature(202)
 
 
 
 
 
Screening(184)
 
 
 
 
Confirmatory(63)
 
 
 
 
 
BioActivity Types:
Potency(57)
 
 
 
 
 
IC50(28)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 454    Data Row: 456   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103178524]
IC50 3.4Antimalarial activity against liver stages of Plasmodium falciparum after 96 hrs [AID683724, Type: Literature]
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2
[SID103178524]
IC50 4.4Induction of iron chelating activity by calcein fluorescence assay [AID460069, Type: Literature]
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3
[SID103178524]
IC50 4.51Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay [AID292406, Type: Literature]
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4
[SID103178524]
IC50 5Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay [AID439762, Type: Literature]
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5
[SID103178524]
IC50 7.35Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay [AID370485, Type: Literature]
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6
[SID103178524]
IC50 8.58Antiproliferative activity against human SK-N-MC cells after 96 hrs by MTT assay [AID271691, Type: Literature]
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7
[SID103178524]
IC50 9.49Toxicity in MDCK cells by MTT method [AID460409, Type: Literature]
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8
[SID103178524]
IC50 9.89Cytotoxicity against human SK-N-MC cells after 72 hrs by MTT assay [AID476194, Type: Literature]
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9
[SID103178524]
IC50 10Iron chelating activity by ferrozine method [AID312353, Type: Literature]
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10
[SID93577020]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID93577020]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID93577020]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID103178524]
IC50 12.05Antiproliferative activity against human SK-MN-C cells by MTT assay [AID312544, Type: Literature]
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14
[SID103178524]
IC50 12.5Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay [AID677905, Type: Literature]
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15
[SID103178524]
IC50 14.22Antiproliferative activity against human SK-N-MC cells by MTT assay [AID303514, Type: Literature]
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16
[SID103178524]
IC50 16.04Toxicity in human SK-N-MC cells by MTT method [AID460410, Type: Literature]
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17
[SID103178524]
IC50 17.07Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay [AID539493, Type: Literature]
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18
[SID103178524]
IC50 17.07Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay [AID671698, Type: Literature]
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19
[SID103178524]
IC50 20Antimalarial activity against liver stages of Plasmodium yoelii after 96 hrs [AID683723, Type: Literature]
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20
[SID93577020]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID93577020]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID93577020]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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23
[SID103178524]
IC50 22Antiproliferative activity against human SK-N-MC cells [AID439761, Type: Literature]
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24
[SID103178524]
IC50 22.7Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTS assay [AID619945, Type: Literature]
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25
[SID103178524]
IC50 36.1Cytotoxicity against human HT29 cells after 72 hrs by MTS assay [AID327128, Type: Literature]
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26
[SID48415847]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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27
[SID103178524]
 Inhibition of iron/ascorbate-induced lipid peroxidation in Sprague-Dawley rat brain mitochondrial membrane homogenate at 15 uM [AID312356, Type: Literature]
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28
[SID103178524]
 Protection against ferrous and hydrogen peroxide-induced single strand breakage of pBR322 DNA at 50 uM after 30 mins using ethium bromide staining [AID427134, Type: Literature]
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29
[SID103178524]
 Inhibition of Fenton's reaction mediated DNA strand break in Escherichia coli pBR322 at 0.1 to 1 uM by gel electrophoresis [AID477992, Type: Literature]
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30
[SID103178524]
 Cell cycle arrest in nocodazole pretreated human HT-29 cells assessed as accumulation at M phase at 10 uM after 24 hrs [AID478034, Type: Literature]
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31
[SID103178524]
 Cell cycle arrest in nocodazole pretreated human HT-29 cells assessed as accumulation at M phase at 5 uM after 24 hrs [AID478035, Type: Literature]
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32
[SID103178524]
 Inhibition of Fenton's reaction mediated DNA strand break in Escherichia coli pBR322 at 1 to 100 uM by gel electrophoresis [AID478051, Type: Literature]
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33
[SID93577020]
 uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]SENP8 gene product [Homo sapiens] [gi:262118306]
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34
[SID93577020]
 Absorbance-based primary bacterial cell-based high throughput screening assay to identify inhibitors of RecBCD (with phage) [AID651602, Type: screening]exonuclease V (RecBCD complex), alpha chain [Escherichia coli str. K-12 substr. MG1655] [gi:16130723]
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35
[SID103178524]
IC50 50Cytotoxicity against human HeLa cells after 72 hrs by MTS assay [AID327127, Type: Literature]
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36
[SID103178524]
IC50 50Antiproliferative activity against human HepaRG cells after 72 hrs by MTT assay [AID460070, Type: Literature]
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37
[SID103178524]
IC50 70Antiproliferative activity against human HepaRG cells after 72 hrs by MTT assay in presence of iron(3) [AID460071, Type: Literature]
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38
[SID103178524]
IC50 112Ability to inhibit iron-dependent lipid peroxidation in rat brain homogenate using MDA (malonyldialdehyde) formation assay [AID181514, Type: Literature]
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39
[SID103178524]
 Tested for Iron clearance of compound, when administered subcutaneously at a dose 150 umol/kg in bile duct cannulated rat [AID186664, Type: Literature]
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40
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 12 hours of po administration. [AID186669, Type: Literature]
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41
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 12 hours of sc administration. [AID186670, Type: Literature]
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42
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 15 hours of po administration. [AID186793, Type: Literature]
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43
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 15 hours of sc administration. [AID186794, Type: Literature]
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44
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 18 hours of po administration. [AID186795, Type: Literature]
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45
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 18 hours of sc administration. [AID186796, Type: Literature]
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46
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 21 hours of po administration. [AID186797, Type: Literature]
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47
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 21 hours of sc administration. [AID186798, Type: Literature]
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48
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 24 hours of po administration. [AID186799, Type: Literature]
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49
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 24 hours of sc administration. [AID186800, Type: Literature]
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50
[SID103178524]
 Total iron output induced by the compound in bile (non-iron-overloaded bile duct cannulated rat), after 3 hours of po administration. [AID186801, Type: Literature]
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