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ST50938922 (CID 2970781) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(525)
 
 
Inconclusive(7)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
ABCC CFTR1(8)
 
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(367)
 
 
 
 
Confirmatory(167)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(123)
 
 
 
 
 
IC50(37)
 
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 497    Data Row: 544   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49823412]
IC50_Mean 3.19Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a TNFa-induced IL8 counterscreen [AID624347, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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2
[SID49823412]
IC50_Mean 9.42Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a PAF-induced IL8 counterscreen [AID624343, Type: confirmatory]interleukin-8 precursor [Homo sapiens] [gi:10834978]
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3
[SID49823412]
Potency 10Confirmation Assay for Identification of Novel General Anesthetics [AID489008, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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4
[SID49823412]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID492953, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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5
[SID49823412]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID493034, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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6
[SID49823412]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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7
[SID49823412]
Single concentration confirmation of uHTS hits for cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID602472, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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8
[SID49823412]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_5, Type: confirmatory]
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9
[SID49823412]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_6, Type: confirmatory]
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10
[SID49823412]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_2, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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11
[SID49823412]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_3, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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12
[SID49823412]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID49823412]
IC50_CF-PAF_Mean 42.7Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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14
[SID49823412]
IC50_CF-PAF_Mean Dose Response confirmation of uHTS small molecule hits for cystic fibrosis induced NFkb Inhibitors in a panel assay [AID624344_1, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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15
[SID49823412]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
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16
[SID49823412]
IC50 uHTS identification of small molecule inhibitors of LYP via a fluorescence intensity assay [AID1779, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 22 isoform 1 [Homo sapiens] [gi:224586929]
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17
[SID49823412]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3) [AID492972, Type: screening]platelet-activating factor acetylhydrolase IB subunit gamma [Homo sapiens] [gi:225543099]
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18
[SID49823412]
IC50 Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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19
[SID49823412]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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20
[SID49823412]
Counterscreen of compound fluorescence effects on High-throughput multiplex microsphere screening for inhibitors of toxin protease [AID624483, Type: screening]
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21
[SID49823412]
uHTS identification of small molecule Triacylglycerol inhbitors in a fluoresence assay [AID651582, Type: screening]
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22
[SID49823412]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
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23
[SID49823412]
DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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24
[SID49823412]
HTS for the detection of C. neoformans cell lysis via adenylate kinase (AK) release Measured in Microorganism System Using Plate Reader - 2162-01_Inhibitor_SinglePoint_HTS_Activity [AID651654, Type: screening]
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25
[SID49823412]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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26
[SID49823412]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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27
[SID49823412]
Potency qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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28
[SID49823412]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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29
[SID49823412]
uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens] [gi:90652859]
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30
[SID49823412]
Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID743445, Type: screening]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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31
[SID49823412]
FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651710, Type: screening]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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32
[SID49823412]
Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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33
[SID49823412]
Inhibitors of Y. pestis Topo-I using cleavage product accumulation Measured in Biochemical System Using Plate Reader - 2123-01_Inhibitor_SinglePoint_HTS_Activity [AID504884, Type: screening]DNA topoisomerase I [Yersinia pestis CO92] [gi:115347926]
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34
[SID49823412]
Counterscreen for inhibitors of 5-meCpG-binding domain protein 2 (MBD2): TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of binding of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) to methylated oligonucleotide [AID687016, Type: screening]E3 ubiquitin-protein ligase UHRF1 isoform 1 [Homo sapiens] [gi:115430235]
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35
[SID49823412]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase type I-alpha regulatory subunit [Bos taurus] [gi:115496662]
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36
[SID49823412]
Potency qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase [AID602233, Type: confirmatory]phosphoglycerate kinase [Trypanosoma brucei] [gi:115503961]
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37
[SID49823412]
Potency qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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38
[SID49823412]
Potency qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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39
[SID49823412]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]perilipin-5 [Homo sapiens] [gi:116292172]
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40
[SID49823412]
Luminescence-based cell-based primary high throughput screening assay to identify inverse agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504357, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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41
[SID49823412]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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42
[SID49823412]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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43
[SID49823412]
Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504810, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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44
[SID49823412]
Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign [AID504812, Type: Literature]TSHR protein [Homo sapiens] [gi:118341367]
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45
[SID49823412]
Potency Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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46
[SID49823412]
Potency qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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47
[SID49823412]
IC50 Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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48
[SID49823412]
C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_SinglePoint_HTS_Activity [AID504423, Type: screening]LANA [Human herpesvirus 8] [gi:312275222]
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49
[SID49823412]
Potency qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720709, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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50
[SID49823412]
Potency qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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