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BioActivity Data for Compound DAPI (CID 2954)

BioActivity Outcomes:
Active(14)
 
 
Inactive(2)
 
 
Unspecified(46)
 
 
Top Targets:
Telomerase RB..(2)
 
 
Gag p30(1)
 
 
Tryp SPc(1)
 
 
BioAssay Types:
Literature(62)
 
 
 
 
BioAssay Categories:
Biochemical(23)
 
 
 
 
Toxicity(2)
 
 
ADME(2)
 
 
Cell-based(7)
 
 
 
BioActivity Types:
IC50(10)
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 62    Data Row: 62   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103232310]
IC50 0.003Antiparasitic activity against Plasmodium falciparum K1 [AID593439, Type: Literature]
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2
[SID103232310]
IC50 0.003Antiparasitic activity against Plasmodium falciparum K1 [AID598108, Type: Literature]
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3
[SID103232310]
IC50 0.003Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 [AID389452, Type: Literature]
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4
[SID103232310]
IC50 0.017Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream trypomastigotes [AID389450, Type: Literature]
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5
[SID103232310]
IC50 0.018Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 [AID593437, Type: Literature]
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6
[SID103232310]
IC50 0.018Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 [AID598107, Type: Literature]
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7
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID593436, Type: Literature]
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8
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID598106, Type: Literature]
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9
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID389449, Type: Literature]
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10
[SID103232310]
Ki 2.7Competitive reversible inhibition of porcine pancreatic kallikrein using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 180 mins by Michaelis-Menten plot analysis [AID1132853, Type: Literature]Glandular kallikrein [gi:20141454]
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11
[SID103232310]
IC50 2.8Inhibition of mouse hippocampal neurons ASIC transfected in CHO cells assessed as inhibition of acid-evoked current at -60 mV holding potential by two-electrode voltage-clamp electrophysiology assay [AID1124807, Type: Literature]
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12
[SID103232310]
Ki 5.31Competitive reversible inhibition of bovine trypsin using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 30 mins by Michaelis-Menten plot analysis [AID1132852, Type: Literature]
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13
[SID103232310]
Ki 8.37Competitive reversible inhibition of bovine thrombin using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 40 mins by Michaelis-Menten plot analysis [AID1132851, Type: Literature]Prothrombin [gi:135806]
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14
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as cured mouse at 20 mg/kg, ip daily for 4 days [AID389461, Type: Literature]
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15
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as survival time at 20 mg/kg, ip administered daily for 4 days [AID389465, Type: Literature]
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16
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as survival time at 5 mg/kg, ip administered daily for 4 days [AID389466, Type: Literature]
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17
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900 [AID593438, Type: Literature]
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18
[SID103232310]
Thermal denaturation in sonicated poly(dA)-poly(dT) homopolymer (AT) [AID31893, Type: Literature]
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19
[SID103232310]
Thermal denaturation in alternating poly(dA-dT)poly(dA-dT) homopolymer (AT) [AID31892, Type: Literature]
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20
[SID103232310]
Inhibition of ASIC3 at 1 uM by patch-clamp electrophysiology assay relative to baseline peak current [AID430747, Type: Literature]
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