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DAPI (CID 2954) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(2)
 
 
Unspecified(43)
 
 
Top Targets:
Telomerase RB..(2)
 
 
Gag p30(1)
 
 
BioAssay Types:
Literature(55)
 
 
 
 
BioActivity Types:
IC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 55    Data Row: 55   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103232310]
IC50 0.003Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 [AID389452, Type: Literature]
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2
[SID103232310]
IC50 0.003Antiparasitic activity against Plasmodium falciparum K1 [AID593439, Type: Literature]
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3
[SID103232310]
IC50 0.003Antiparasitic activity against Plasmodium falciparum K1 [AID598108, Type: Literature]
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4
[SID103232310]
IC50 0.017Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream trypomastigotes [AID389450, Type: Literature]
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5
[SID103232310]
IC50 0.018Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 [AID598107, Type: Literature]
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6
[SID103232310]
IC50 0.018Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 [AID593437, Type: Literature]
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7
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID389449, Type: Literature]
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8
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID593436, Type: Literature]
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9
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID598106, Type: Literature]
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10
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as cured mouse at 20 mg/kg, ip daily for 4 days [AID389461, Type: Literature]
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11
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as survival time at 20 mg/kg, ip administered daily for 4 days [AID389465, Type: Literature]
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12
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as survival time at 5 mg/kg, ip administered daily for 4 days [AID389466, Type: Literature]
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13
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB 900 [AID389451, Type: Literature]
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14
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine-resistant Plasmodium falciparum K1 [AID389453, Type: Literature]
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15
[SID103232310]
Inhibition of ASIC3 at 1 uM by patch-clamp electrophysiology assay relative to baseline peak current [AID430747, Type: Literature]
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16
[SID103232310]
Inhibition of ASIC3 at 10 uM by patch-clamp electrophysiology assay relative to baseline peak current [AID430748, Type: Literature]
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17
[SID103232310]
Dissociation constant, pKa of the compound [AID477816, Type: Literature]
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18
[SID103232310]
Antibacterial activity against Escherichia coli KAM32 harboring plasmid pUC18 by CLSI broth microdilution method [AID571882, Type: Literature]
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19
[SID103232310]
Antibacterial activity against Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene by CLSI broth microdilution method [AID571884, Type: Literature]
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20
[SID103232310]
Ratio of MIC for Escherichia coli KAM32 harboring plasmid pUC18 to MIC for Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene [AID572058, Type: Literature]
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