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DAPI (CID 2954) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(2)
 
 
Unspecified(43)
 
 
Top Targets:
Telomerase RB..(2)
 
 
Gag p30(1)
 
 
BioAssay Types:
Literature(55)
 
 
 
 
BioActivity Types:
IC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 55    Data Row: 55   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103232310]
IC50 0.003Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 [AID389452, Type: Literature]
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2
[SID103232310]
IC50 0.003Antiparasitic activity against Plasmodium falciparum K1 [AID598108, Type: Literature]
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3
[SID103232310]
IC50 0.003Antiparasitic activity against Plasmodium falciparum K1 [AID593439, Type: Literature]
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4
[SID103232310]
IC50 0.017Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream trypomastigotes [AID389450, Type: Literature]
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5
[SID103232310]
IC50 0.018Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 [AID598107, Type: Literature]
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6
[SID103232310]
IC50 0.018Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 [AID593437, Type: Literature]
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7
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID389449, Type: Literature]
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8
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID593436, Type: Literature]
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9
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID598106, Type: Literature]
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10
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as cured mouse at 20 mg/kg, ip daily for 4 days [AID389461, Type: Literature]
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11
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as survival time at 20 mg/kg, ip administered daily for 4 days [AID389465, Type: Literature]
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12
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as survival time at 5 mg/kg, ip administered daily for 4 days [AID389466, Type: Literature]
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13
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900 [AID593438, Type: Literature]
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14
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1 [AID593440, Type: Literature]
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15
[SID103232310]
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as mean relapse day of parasitemia at 5 mg/kg, ip for 4 days [AID593471, Type: Literature]
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16
[SID103232310]
Binding affinity to poly(dA-dT)n DNA assessed as change in melting temperature at 0.3:1 molar compound/DNA ratio by spectrophotometry [AID598105, Type: Literature]
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17
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB 900 [AID389451, Type: Literature]
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18
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine-resistant Plasmodium falciparum K1 [AID389453, Type: Literature]
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19
[SID103232310]
Binding constant obtained in an ethidium displacement assay for the sequence d(CGGAATTCGCG)2 [AID227749, Type: Literature]
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20
[SID103232310]
Thermal melting temperature for (dCGCGAATTCGCG)2 at a concentration of 3*10e-6 M base pairs at a ratio of 0.6 compound per base pair [AID233022, Type: Literature]
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21
[SID103232310]
Thermal melting temperature determined for (dG-C)4 at a concentration of 3*10e-6 M base pairs at a ratio of 0.6 compound per base pair [AID233023, Type: Literature]
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22
[SID103232310]
Thermal melting temperature for poly(A).poly(U) at a concentration of 5*10e-5) M base pairs at a ratio of 0.6 compound per base pair [AID233024, Type: Literature]
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23
[SID103232310]
Thermal melting temperature determined for poly(dA).poly(dT) at a concentration of 5*10e-5) M base pairs at a ratio of 0.6 compound per base pair [AID233025, Type: Literature]
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24
[SID103232310]
Ratio between poly-dAdT and poly-dGdC binding [AID233938, Type: Literature]
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25
[SID103232310]
Inhibition of ASIC3 at 1 uM by patch-clamp electrophysiology assay relative to baseline peak current [AID430747, Type: Literature]
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26
[SID103232310]
Inhibition of ASIC3 at 10 uM by patch-clamp electrophysiology assay relative to baseline peak current [AID430748, Type: Literature]
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27
[SID103232310]
Dissociation constant, pKa of the compound [AID477816, Type: Literature]
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28
[SID103232310]
Antibacterial activity against Escherichia coli KAM32 harboring plasmid pUC18 by CLSI broth microdilution method [AID571882, Type: Literature]
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29
[SID103232310]
Antibacterial activity against Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene by CLSI broth microdilution method [AID571884, Type: Literature]
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30
[SID103232310]
Ratio of MIC for Escherichia coli KAM32 harboring plasmid pUC18 to MIC for Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene [AID572058, Type: Literature]
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31
[SID103232310]
Antibacterial activity against Acinetobacter baumannii AC0037 by CLSI broth microdilution method [AID572059, Type: Literature]
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32
[SID103232310]
Antibacterial activity against abeS-deficient Acinetobacter baumannii AC0037 by CLSI broth microdilution method [AID572060, Type: Literature]
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33
[SID103232310]
Ratio of MIC for Acinetobacter baumannii AC0037 to MIC for abeS-deficient Acinetobacter baumannii AC0037 [AID572061, Type: Literature]
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34
[SID103232310]
Antibacterial activity against abeS sigma abeS-deficient Acinetobacter baumannii AC0037 by CLSI broth microdilution method [AID572062, Type: Literature]
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35
[SID103232310]
Binding affinity to poly(dA-dT)2DNA assessed as change in melting temperature [AID593435, Type: Literature]
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36
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900 [AID598109, Type: Literature]
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37
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1 [AID598110, Type: Literature]
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38
[SID103232310]
Binding affinity to human pre-hsa-mir-155 miRNA assessed as inhibition of dicer-catalysed (33P)-labelled pre-miRNA processing at 1 mM after 1 hr by PAGE analysis [AID644953, Type: Literature]
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39
[SID103232310]
Denaturation temperature change on binding to AT to poly (dA)-poly(dT) [AID54423, Type: Literature]
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40
[SID103232310]
Denaturation temperature change on binding on GC to poly(dGC)-poly(dGC) [AID54424, Type: Literature]
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41
[SID103232310]
DNA binding property estimated by measuring denaturation temperature on GC to poly (dGC)-poly(dGC), normalized to ethidium bromide [AID54425, Type: Literature]
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42
[SID103232310]
Denaturation temperature change on binding to calf thymus DNA [AID54426, Type: Literature]
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43
[SID103232310]
DNA binding activity as denaturation temperatures on AT to poly (dA)-poly(dT) normalized to ethidium bromide [AID54427, Type: Literature]
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44
[SID103232310]
Thermal denaturation in sonicated calf thymus DNA (CT DNA) [AID54984, Type: Literature]
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45
[SID103232310]
Thermal denaturation in alternating poly(dG-dC)-poly(dG-dC) homopolymer (GC) [AID72882, Type: Literature]
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46
[SID103232310]
Inhibition of purified telomerase of Euplotes aediculatus at 50 uM [AID212741, Type: Literature]
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47
[SID103232310]
Inhibition of telomerase after assembly using recombinant Tetraymena thermophilia TR and TERT at 50 uM [AID212743, Type: Literature]
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48
[SID103232310]
Inhibition of telomerase before assembly using recombinant Tetraymena thermophilia TR and TERT at 50 uM [AID212744, Type: Literature]
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49
[SID103232310]
Thermal denaturation in alternating poly(dA-dT)poly(dA-dT) homopolymer (AT) [AID31892, Type: Literature]
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50
[SID103232310]
Thermal denaturation in sonicated poly(dA)-poly(dT) homopolymer (AT) [AID31893, Type: Literature]
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