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DAPI (CID 2954) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(2)
 
 
Unspecified(43)
 
 
Top Targets:
Telomerase RB..(2)
 
 
Gag p30(1)
 
 
BioAssay Types:
Literature(55)
 
 
 
 
BioActivity Types:
IC50(9)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 55    Data Row: 55   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103232310]
IC50 0.003Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 [AID389452, Type: Literature]
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2
[SID103232310]
IC50 0.003Antiparasitic activity against Plasmodium falciparum K1 [AID598108, Type: Literature]
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3
[SID103232310]
IC50 0.003Antiparasitic activity against Plasmodium falciparum K1 [AID593439, Type: Literature]
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4
[SID103232310]
IC50 0.017Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 bloodstream trypomastigotes [AID389450, Type: Literature]
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5
[SID103232310]
IC50 0.018Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 [AID598107, Type: Literature]
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6
[SID103232310]
IC50 0.018Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 [AID593437, Type: Literature]
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7
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID389449, Type: Literature]
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8
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID593436, Type: Literature]
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9
[SID103232310]
IC50 0.86Cytotoxicity against rat L6 cells [AID598106, Type: Literature]
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10
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as cured mouse at 20 mg/kg, ip daily for 4 days [AID389461, Type: Literature]
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11
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as survival time at 20 mg/kg, ip administered daily for 4 days [AID389465, Type: Literature]
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12
[SID103232310]
Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 infected acute mouse model assessed as survival time at 5 mg/kg, ip administered daily for 4 days [AID389466, Type: Literature]
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13
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB900 [AID593438, Type: Literature]
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14
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1 [AID593440, Type: Literature]
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15
[SID103232310]
Antiparasitic activity against Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as mean relapse day of parasitemia at 5 mg/kg, ip for 4 days [AID593471, Type: Literature]
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16
[SID103232310]
Binding affinity to poly(dA-dT)n DNA assessed as change in melting temperature at 0.3:1 molar compound/DNA ratio by spectrophotometry [AID598105, Type: Literature]
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17
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Trypanosoma brucei rhodesiense STIB 900 [AID389451, Type: Literature]
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18
[SID103232310]
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for chloroquine-resistant Plasmodium falciparum K1 [AID389453, Type: Literature]
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19
[SID103232310]
Binding constant obtained in an ethidium displacement assay for the sequence d(CGGAATTCGCG)2 [AID227749, Type: Literature]
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20
[SID103232310]
Thermal melting temperature for (dCGCGAATTCGCG)2 at a concentration of 3*10e-6 M base pairs at a ratio of 0.6 compound per base pair [AID233022, Type: Literature]
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