STK336693 (CID 2953653) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(28)
 
 
Inactive(511)
 
 
Inconclusive(16)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(13)
 
 
7TM GPCR Srsx(9)
 
 
PTPc(9)
 
 
 
Tryp SPc(6)
 
 
 
alkPPc(6)
 
 
BioAssay Types:
Screening(417)
 
 
 
 
 
Confirmatory(121)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(75)
 
 
 
 
 
IC50(23)
 
 
 
EC50(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 556    Data Row: 557   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26668946]
IC50 0.409Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay [AID602367, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 11 [Homo sapiens] [gi:33356177]
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2
[SID26668946]
IC50 0.409Dose Response selectivity of inhibitors of Striatal-Enriched Phosphatase (STEP) in a SHP2 (PTPN11) Inhibition Assay [AID602367, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 11 [Homo sapiens] [gi:33356177]
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3
[SID26668946]
IC50 0.716Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay [AID602374, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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4
[SID26668946]
IC50 0.716Dose Response selectivity of inhibitors of STriatal-Enriched Phosphatase (STEP) in the dual-specificity protein-tyrosine phosphatase VHR Inhibition Assay [AID602374, Type: confirmatory]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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5
[SID4263927]
IC50 1.5HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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6
[SID4263927]
IC50 1.5HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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7
[SID4263927]
IC50 1.5HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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8
[SID4263927]
IC50 2.479Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID651680, Type: confirmatory]ASAP1 gene product [Homo sapiens] [gi:351542238]
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9
[SID4263927]
Potency 15.8489qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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10
[SID26668946]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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11
[SID4263927]
 HIV-1 RT-RNase H MLSCN HTS MH077605 [AID565, Type: screening]Chain A, Hiv-1 Reverse Transcriptase Mol_id: 1; Molecule: Hiv-1 Reverse Transcriptase; Chain: A, B; [gi:1431733]
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12
[SID4263927]
 MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Activator_SinglePoint_HTS_Activity [AID651723, Type: screening]
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13
[SID4263927]
 Profiling the NIH Molecular Libraries Small Molecule Repository: Autofluorescence at 339/460 nm [AID709, Type: screening]
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14
[SID4263927]
 qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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15
[SID4263927]
 qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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16
[SID4263927]
 qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region [AID593, Type: other]
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17
[SID4263927]
 Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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18
[SID4263927]
 384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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19
[SID4263927]
 Human Endothelial Cell Proliferation Assay in 384-well format [AID648, Type: screening]
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20
[SID4263927]
 uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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21
[SID4263927]
 uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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22
[SID4263927]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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23
[SID4263927]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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24
[SID4263927]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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25
[SID4263927]
 HTS of Estrogen Receptor- alpha Coactivator Binding inhibitors [AID629, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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26
[SID4263927]
 uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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27
[SID4263927]
 uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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28
[SID4263927]
 Primary biochemical high-throughput screening assay for inhibitors of Focal Adhesion Kinase (FAK) [AID727, Type: screening]Focal adhesion kinase 1 [gi:3183518]
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29
[SID4263927]
 Primary biochemical high-throughput screening assay for inhibitors of Focal Adhesion Kinase (FAK) [AID727, Type: screening]Focal adhesion kinase 1 [gi:3183518]
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30
[SID26668946]
 Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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31
[SID26668946]
 Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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32
[SID26668946]
 Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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33
[SID4263927]
 Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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34
[SID4263927]
 Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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35
[SID4263927]
 Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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36
[SID4263927]
 Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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37
[SID4263927]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]ASAP1 gene product [Homo sapiens] [gi:351542238]
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38
[SID4263927]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624431, Type: screening]ASAP1 gene product [Homo sapiens] [gi:351542238]
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39
[SID4263927]
 LYP Inhibitors-an Autoimmunity Target - Primary screen [AID640, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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40
[SID4263927]
 LYP Inhibitors-an Autoimmunity Target - Primary screen [AID640, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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41
[SID4263927]
 LYP Inhibitors-an Autoimmunity Target - Primary screen [AID640, Type: screening]PTPN22 gene product [Homo sapiens] [gi:224586929]
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42
[SID4263927]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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43
[SID4263927]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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44
[SID26668946]
 Single concentration confirmation molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID623866, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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45
[SID26668946]
 Single concentration confirmation molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID623866, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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46
[SID4263927]
 Single concentration validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602333, Type: screening]prothrombin [Bos taurus] [gi:296479639]
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47
[SID4263927]
 Single concentration validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602333, Type: screening]prothrombin [Bos taurus] [gi:296479639]
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48
[SID4263927]
 uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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49
[SID4263927]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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50
[SID4263927]
 Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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