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CID2950007 (CID 2950007) - Compound BioActivity Data
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BioActivity Outcomes:
Probe(1)
 
 
Active(35)
 
 
Inactive(666)
 
 
Inconclusive(43)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(17)
 
 
Bcl-2 like(11)
 
 
Ras like GTPa..(10)
 
 
 
alkPPc(10)
 
 
BioAssay Types:
Screening(461)
 
 
 
 
 
Confirmatory(235)
 
 
 
 
 
Literature(6)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(154)
 
 
 
 
 
IC50(39)
 
 
 
EC50(36)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 668    Data Row: 752   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57578341]
Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein, partial [Homo sapiens] [gi:190938]
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2
[SID57644019]
EC50_MICROM 0.263Dose Response of compounds with constant GTP under the condition of nascent nucleotide depletion and Mg buffer [AID2376, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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3
[SID24796017]
Potency 0.5805A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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4
[SID57578341]
EC50_MICROM 0.704Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID1337, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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5
[SID24796017]
EC50_MICROM 0.7042Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID1337, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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6
[SID57578341]
EC50_MICROM 0.823SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 precursor [Homo sapiens] [gi:4757952]
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7
[SID57578341]
EC50_MICROM 1.89SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588373, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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8
[SID24796017]
EC50 2.829Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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9
[SID24796017]
EC50_MICROM 3.198Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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10
[SID57578341]
EC50_MICROM 3.2Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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11
[SID24796017]
EC50_MICROM 8.039Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID1333, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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12
[SID57578341]
EC50_MICROM 8.04Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID1333, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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13
[SID24796017]
Potency 9.5283qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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14
[SID24796017]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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15
[SID24796017]
Potency 16.3601A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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16
[SID118043962]
Actin Polymerization inhibition by compounds from Cdc42 Probe Extension Project [AID652107, Type: other]actin, cytoplasmic 1 [Homo sapiens] [gi:4501885]
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17
[SID57644019]
PAK-Effector Pull-down Assay for Quantification of Rac/Cdc42 Activation Using 3T3 Cells [AID2374, Type: other]p21 activated kinase 1B [Homo sapiens] [gi:3265160]
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18
[SID57644019]
Panel results of Cell based ELISA Assessing Activation of Cdc42 and Rac1 [AID2375_1, Type: other]
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19
[SID57644019]
Panel results of Cell based ELISA Assessing Activation of Cdc42 and Rac1 [AID2375_2, Type: other]
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20
[SID57644019]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_3, Type: other]
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21
[SID57644019]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_4, Type: other]
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22
[SID57644019]
Assessment of Cdc42 inhibitors on Bradykinin activation of 3T3 cells [AID2418, Type: other]
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23
[SID24796017]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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24
[SID24796017]
Parallel artificial membrane permeability assay at pH 7.4 [AID624339, Type: other]
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25
[SID24796017]
Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
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26
[SID24796017]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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27
[SID24796017]
Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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28
[SID57644019]
Compound effect on equilibrium binding with Cdc42 under varying GTP conditions: nucleotide depletion with Mg buffer [AID2372, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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29
[SID57644019]
Compound effect on equilibrium binding with Cdc42 under varying GTP conditions with Mg buffer [AID2373, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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30
[SID24796017]
Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-7 [AID463210, Type: screening]caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] [gi:55960760]
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31
[SID57578341]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_1, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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32
[SID57578341]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_2, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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33
[SID24796017]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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34
[SID24796017]
Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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35
[SID57644019]
Compound effect on equilibrium binding with Cdc42 under varying GTP conditions with EDTA buffer [AID2378, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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36
[SID24796017]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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37
[SID24796017]
Plasma Stability Mouse - Set 2 [AID624419, Type: other]
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38
[SID24796017]
Plasma Stability Human - 2 [AID624420, Type: other]
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39
[SID24796017]
Mouse hepatic microsome stability - Set 2 [AID624451, Type: screening]
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40
[SID24796017]
Human hepatic microsome stability-Set 2 [AID624452, Type: screening]
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41
[SID24796017]
Early assessment of compound stability in 1x PBS - Set 2 [AID624456, Type: other]
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42
[SID57644019]
Early assessment of compound stability in 1x PBS [AID493010, Type: other]
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43
[SID24796017]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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44
[SID174006975]
Potency 0.0841qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743345, Type: confirmatory]
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45
[SID24796017]
Potency 3.9811qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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46
[SID24796017]
Potency 5.0119qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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47
[SID24796017]
Potency 10qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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48
[SID174006975]
Potency 10.5839qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation [AID743347, Type: confirmatory]
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49
[SID174006975]
Potency 11.8754qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation [AID743344, Type: confirmatory]
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50
[SID24796017]
Potency 15.8489qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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