4-[5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide (CID 2950007) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Probe(1)
 
 
Active(35)
 
 
Inactive(568)
 
 
Inconclusive(35)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
alkPPc(10)
 
 
Ras like GTPa..(10)
 
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(8)
 
 
BioAssay Types:
Screening(393)
 
 
 
 
 
Confirmatory(203)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(126)
 
 
 
 
 
EC50(36)
 
 
 
 
IC50(35)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 622    Data Row: 646   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57578341]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
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2
[SID57578341]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
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3
[SID57578341]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
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4
[SID57644019]
EC50 0.263Dose Response of compounds with constant GTP under the condition of nascent nucleotide depletion and Mg buffer [AID2376, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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5
[SID24796017]
Potency 0.5805A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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6
[SID57578341]
EC50 0.704Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID1337, Type: confirmatory]Ras-related protein Rab-2 [gi:46577642]
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7
[SID24796017]
EC50 0.7042Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID1337, Type: confirmatory]Ras-related protein Rab-2 [gi:46577642]
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8
[SID57578341]
EC50 0.823SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 [Homo sapiens] [gi:4757952]
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9
[SID57578341]
EC50 0.823SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 [Homo sapiens] [gi:4757952]
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10
[SID57578341]
EC50 1.89SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588373, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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11
[SID24796017]
EC50 2.829Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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12
[SID24796017]
EC50 3.198Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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13
[SID57578341]
EC50 3.2Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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14
[SID24796017]
EC50 8.039Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID1333, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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15
[SID57578341]
EC50 8.04Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID1333, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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16
[SID24796017]
Potency 9.5283qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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17
[SID24796017]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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18
[SID24796017]
Potency 16.3601A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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19
[SID24796017]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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20
[SID57644019]
 PAK-Effector Pull-down Assay for Quantification of Rac/Cdc42 Activation Using 3T3 Cells [AID2374, Type: other]p21 activated kinase 1B [Homo sapiens] [gi:3265160]
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21
[SID57644019]
 PAK-Effector Pull-down Assay for Quantification of Rac/Cdc42 Activation Using 3T3 Cells [AID2374, Type: other]p21 activated kinase 1B [Homo sapiens] [gi:3265160]
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22
[SID57644019]
 PAK-Effector Pull-down Assay for Quantification of Rac/Cdc42 Activation Using 3T3 Cells [AID2374, Type: other]p21 activated kinase 1B [Homo sapiens] [gi:3265160]
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23
[SID24796017]
 Parallel artificial membrane permeability assay at pH 7.4 [AID624339, Type: other]
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24
[SID24796017]
 Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
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25
[SID24796017]
 Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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26
[SID24796017]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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27
[SID57644019]
 Panel results of Cell based ELISA Assessing Activation of Cdc42 and Rac1 [AID2375_1, Type: other]
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28
[SID57644019]
 Panel results of Cell based ELISA Assessing Activation of Cdc42 and Rac1 [AID2375_2, Type: other]
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29
[SID57644019]
 Assessment of Cdc42 inhibitors on Bradykinin activation of 3T3 cells [AID2418, Type: other]
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30
[SID24796017]
 384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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31
[SID57644019]
 Compound effect on equilibrium binding with Cdc42 under varying GTP conditions with EDTA buffer [AID2378, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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32
[SID57578341]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_1, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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33
[SID57578341]
 Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_2, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
34
[SID24796017]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
View
35
[SID57644019]
 Compound effect on equilibrium binding with Cdc42 under varying GTP conditions: nucleotide depletion with Mg buffer [AID2372, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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36
[SID57644019]
 Compound effect on equilibrium binding with Cdc42 under varying GTP conditions with Mg buffer [AID2373, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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37
[SID118043962]
 Actin Polymerization inhibition by compounds from Cdc42 Probe Extension Project [AID652107, Type: other]ACTB gene product [Homo sapiens] [gi:4501885]
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38
[SID24796017]
 Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-7 [AID463210, Type: screening]caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] [gi:55960760]
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39
[SID57644019]
 Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_3, Type: other]Rho GTPase activating protein 1 [Homo sapiens] [gi:4757766]
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40
[SID57644019]
 Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_4, Type: other]Rho GTPase activating protein 1 [Homo sapiens] [gi:4757766]
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41
[SID24796017]
 Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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42
[SID24796017]
 Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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43
[SID24796017]
 Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
View
44
[SID24796017]
 Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]CASP3 gene product [Homo sapiens] [gi:14790119]
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45
[SID24796017]
 Plasma Stability Mouse - Set 2 [AID624419, Type: other]
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46
[SID24796017]
 Plasma Stability Human - 2 [AID624420, Type: other]
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47
[SID24796017]
 Mouse hepatic microsome stability - Set 2 [AID624451, Type: screening]
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48
[SID24796017]
 Human hepatic microsome stability-Set 2 [AID624452, Type: screening]
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49
[SID24796017]
 Early assessment of compound stability in 1x PBS - Set 2 [AID624456, Type: other]
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50
[SID57644019]
 Early assessment of compound stability in 1x PBS [AID493010, Type: other]
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