danthron (CID 2950) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(27)
 
 
Inactive(811)
 
 
Inconclusive(132)
 
 
Unspecified(77)
 
 
Top Targets:
Bcl-2 like(13)
 
 
 
NR LBD PPAR(11)
 
 
 
7TM GPCR Srx(10)
 
 
alkPPc(10)
 
 
NR LBD TR(8)
 
 
 
BioAssay Types:
Confirmatory(395)
 
 
 
 
Screening(283)
 
 
 
 
Literature(121)
 
 
 
 
 
BioActivity Types:
Potency(258)
 
 
 
 
IC50(38)
 
 
 
 
 
EC50(9)
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 731    Data Row: 1047   Total Pages: 21   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389963]
Potency 3.5481qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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2
[SID17389963]
Potency 4.7308qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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3
[SID103240009]
IC50 5.7Antiangiogenic activity against BAEC assessed as inhibition of bFGF-induced cell proliferation after 3 days by MTT assay [AID336135, Type: Literature]
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4
[SID17389963]
Potency 7.4978qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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5
[SID8139970]
Potency 7.9433qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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6
[SID103240009]
IC50 20.1Antiangiogenic activity against BAEC assessed as inhibition of bFGF-induced cell proliferation in presence of 10% fetal bovine serum after 3 days by MTT assay [AID336134, Type: Literature]
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7
[SID26747347]
Potency 28.1838qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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8
[SID17389963]
Potency 29.8493qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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9
[SID17389963]
Potency 29.8493qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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10
[SID17389963]
Potency 29.8493qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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11
[SID17389963]
Potency 29.8493qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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12
[SID26747347]
Potency 35.4813qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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13
[SID26747347]
Potency 35.4813qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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14
[SID26747347]
Potency 35.4813qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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15
[SID8139970]
 Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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16
[SID8139970]
 Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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17
[SID8139970]
 Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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18
[SID8139970]
 Counterscreen for MCL1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2166, Type: screening]bcl-2-like protein 1 isoform 1 [Homo sapiens] [gi:20336335]
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19
[SID8139970]
 Counterscreen for MCL1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2166, Type: screening]bcl-2-like protein 1 isoform 1 [Homo sapiens] [gi:20336335]
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20
[SID8139970]
 Counterscreen for MCL1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2166, Type: screening]bcl-2-like protein 1 isoform 1 [Homo sapiens] [gi:20336335]
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21
[SID8139970]
 Single concentration confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. [AID488857, Type: screening]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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22
[SID8139970]
 Single concentration confirmation of inhibitors of NALP1 in yeast using a Caspase-1-ASC counter screen. [AID488857, Type: screening]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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23
[SID8139970]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2168, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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24
[SID8139970]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2168, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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25
[SID8139970]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2168, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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26
[SID8139970]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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27
[SID8139970]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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28
[SID8139970]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. [AID2057, Type: screening]Myeloid cell leukemia sequence 1 (BCL2-related) [Homo sapiens] [gi:78070770]
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29
[SID17389963]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
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30
[SID17389963]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
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31
[SID48413465]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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32
[SID48413465]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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33
[SID48413465]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results [AID1199, Type: other]
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34
[SID48413465]
 DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity [AID1194, Type: other]
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35
[SID48413465]
 DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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36
[SID85789570]
 Luminescence Homogenous Primary HTS to Identify Inhibitors of STK33 Activity [AID2322, Type: screening]
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37
[SID73151]
 NCI Yeast Anticancer Drug Screen. Data for the rad50 strain [AID155, Type: other]
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38
[SID8139970]
 Single concentration confirmation of uHTS for the identification of inhibitors of NALP1 in yeast using a luminescent assay [AID488841, Type: screening]NACHT, LRR and PYD domains-containing protein 1 isoform 1 [Homo sapiens] [gi:14719829]
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39
[SID8139970]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of GLD-1 protein - TGE RNA interaction. [AID2280, Type: screening]defective in Germ Line Development family member (gld-1) [Caenorhabditis elegans] [gi:17507875]
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40
[SID8139970]
 uHTS Luminescent assay for identification of inhibitors of NALP3 in yeast [AID2825, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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41
[SID8139970]
 Single concentration confirmation of uHTS for the identification of inhibitors of NALP3 in yeast using a luminescent assay [AID435006, Type: screening]NLRP3 protein [Homo sapiens] [gi:219518789]
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42
[SID103240009]
IC50 5Antiproliferative (inhibition of cell growth) activity against HaCaT cells (human keratinocyte line) [AID85482, Type: Literature]
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43
[SID103240009]
IC50 305-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL) [AID160507, Type: Literature]5-lipoxygenase [gi:75066909]
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44
[SID103240009]
Ki 40Inhibitory constant against maize casein kinase 2 [AID435887, Type: Literature]
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45
[SID103240009]
IC50 200Inhibition of rat liver mitochondrial TrxR2 by spectrophotometry [AID551521, Type: Literature]Thioredoxin reductase 2, mitochondrial [gi:172045556]
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46
[SID103240009]
IC50 200Inhibition of rat liver cytosolic TrxR1 by spectrophotometry [AID551520, Type: Literature]Thioredoxin reductase 1, cytoplasmic [gi:357529586]
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47
[SID103240009]
IC50 200Inhibition of rat liver cytosolic TrxR1 by spectrophotometry [AID551520, Type: Literature]Thioredoxin reductase 1, cytoplasmic [gi:357529586]
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48
[SID103240009]
IC50 710Inhibition of Trypanosoma cruzi trans-sialidase containing catalytic domain (N58F, R200K) and lectin-like domain (S495 K, V496G, E520K, D593G, I597D, H599R) mutation expressed in Escherichia coli JM109 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assay [AID466937, Type: Literature]
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49
[SID103240009]
IC50 1000Inhibition of human Neu2 assessed as MuNANA substrate hydrolysis in presence of 0.1% Triton X-100 by discontinuous fluorimetric assay [AID466938, Type: Literature]Sialidase-2 [gi:229462907]
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50
[SID103240009]
MIC 25000Antibacterial activity against Proteus mirabilis at pH 6 [AID311296, Type: Literature]
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