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danthron (CID 2950) - Compound BioActivity Data
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BioActivity Outcomes:
Active(43)
 
 
Inactive(990)
 
 
Inconclusive(173)
 
 
Unspecified(101)
 
 
Top Targets:
NR LBD PPAR(27)
 
 
 
NR LBD ER(19)
 
 
 
 
NR LBD AR(16)
 
 
 
NR LBD TR(14)
 
 
 
Bcl-2 like(14)
 
 
 
BioAssay Types:
Confirmatory(550)
 
 
 
 
Screening(301)
 
 
 
 
Literature(166)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(441)
 
 
 
 
IC50(43)
 
 
 
 
 
EC50(9)
 
 
Kd(2)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 862    Data Row: 1307   Total Pages: 66   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144204673]
Potency-Replicate_1 2.371qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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2
[SID144208184]
Potency-Replicate_1 3.095qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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3
[SID144204673]
Ratio Potency (uM) 3.34915qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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4
[SID17389963]
Potency 3.5481qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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5
[SID17389963]
Potency 4.7308qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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6
[SID144208184]
Ratio Potency (uM) 5.50372qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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7
[SID103240009]
IC50 5.7Antiangiogenic activity against BAEC assessed as inhibition of bFGF-induced cell proliferation after 3 days by MTT assay [AID336135, Type: Literature]
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8
[SID170483018]
Kd 6.2Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain B, Crystal Structure Of Tetrameric Rxralpha-Lbd Complexed With Antagonist Danthron [gi:312207944]
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9
[SID170483018]
Kd 6.2Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain B, Crystal Structure Of Tetrameric Rxralpha-Lbd Complexed With Antagonist Danthron [gi:312207944]
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10
[SID17389963]
Potency 7.4978qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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11
[SID8139970]
Potency 7.9433qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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12
[SID144208184]
Potency-Replicate_1 19.5279qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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13
[SID144208184]
Ratio Potency (uM) 19.5279qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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14
[SID103240009]
IC50 20.1Antiangiogenic activity against BAEC assessed as inhibition of bFGF-induced cell proliferation in presence of 10% fetal bovine serum after 3 days by MTT assay [AID336134, Type: Literature]
View
15
[SID170465532]
Ratio Potency (uM) 26.6011qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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16
[SID26747347]
Potency 28.1838qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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17
[SID17389963]
Potency 29.8493qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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18
[SID144208184]
Potency-Replicate_1 30.9497qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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19
[SID26747347]
Potency 35.4813qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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20
[SID8139970]
Counterscreen for MCL1 inhibitors: fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2166, Type: screening]bcl-2-like protein 1 isoform 1 [Homo sapiens] [gi:20336335]
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