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BioActivity Data for Compound SMR000074649 (CID 2947289)

BioActivity Outcomes:
Active(45)
 
 
Inactive(726)
 
 
Inconclusive(30)
 
 
Unspecified(2)
 
 
Top Targets:
7tm 4(45)
 
 
 
 
alkPPc(12)
 
 
Tryp SPc(12)
 
 
NR LBD PPAR(10)
 
 
 
Bcl-2 like(9)
 
 
BioAssay Types:
Screening(496)
 
 
 
 
Confirmatory(263)
 
 
 
 
 
Literature(13)
 
 
BioActivity Types:
Potency(171)
 
 
 
 
 
IC50(46)
 
 
EC50(18)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 715    Data Row: 803   Total Pages: 41   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4263427]
EC50 3.261TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1684, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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2
[SID4263427]
EC50 3.261TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1684, Type: confirmatory]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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3
[SID4263427]
EC50 4.727TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1681, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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4
[SID4263427]
EC50 4.727TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1681, Type: confirmatory]NCOA2 protein [Homo sapiens] [gi:62201602]
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5
[SID4263427]
EC50 6.301TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1679, Type: confirmatory]nuclear receptor coactivator 1 [Homo sapiens] [gi:152112968]
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6
[SID4263427]
EC50 6.301TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1679, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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7
[SID4263427]
Potency 26.6795qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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8
[SID4263427]
EC50 50A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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9
[SID4263427]
Potency qHTS for Inhibitors of KCHN2 3.1: Mutant qHTS [AID720553, Type: confirmatory]potassium voltage-gated channel subfamily H member 2 isoform a, partial [Homo sapiens] [gi:342840031]
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10
[SID4263427]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]LuxS, partial [Vibrio harveyi] [gi:166202459]
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11
[SID4263427]
Confirmation biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1297, Type: screening]NCOA2 protein [Homo sapiens] [gi:62201602]
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12
[SID4263427]
Luminescence Microorganism Retest to Identify Inhibitors of the AI-2 Quorum Sensing System [AID2727, Type: screening]Luminescence regulatory protein luxO [gi:160409943]
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13
[SID4263427]
Luminescence Microorganism Retest to Identify Inhibitors of the AI-2 Quorum Sensing System [AID2727, Type: screening]Phosphorelay protein luxU [gi:160409944]
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14
[SID4263427]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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15
[SID4263427]
Luminescence Microorganism-Based Retest to Identify Modulators of the AI-2 Quorum Sensing System [AID2736, Type: screening]LuxS, partial [Vibrio harveyi] [gi:166202459]
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16
[SID4263427]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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17
[SID4263427]
Dose Response Assay for S1P3 Antagonists [AID484, Type: confirmatory]sphingosine 1-phosphate receptor 3 [Homo sapiens] [gi:38788193]
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18
[SID4263427]
Primary HTS Assay for S1P3 Antagonists [AID485, Type: screening]sphingosine 1-phosphate receptor 3 [Homo sapiens] [gi:38788193]
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19
[SID4263427]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1032, Type: screening]NCOA2 protein [Homo sapiens] [gi:62201602]
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20
[SID4263427]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]Chain A, Crystal Structure Of The Apo Form Of Vibrio Harveyi Luxp Complexed With The Periplasmic Domain Of Luxq [gi:67463988]
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