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SMR000074649 (CID 2947289) - Compound BioActivity Data
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BioActivity Outcomes:
Active(45)
 
 
Inactive(717)
 
 
Inconclusive(30)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(22)
 
 
 
 
Tryp SPc(12)
 
 
alkPPc(12)
 
 
NR LBD PPAR(10)
 
 
 
BioAssay Types:
Screening(495)
 
 
 
 
Confirmatory(261)
 
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(171)
 
 
 
 
 
IC50(44)
 
 
EC50(18)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 713    Data Row: 794   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4263427]
EC50 3.261TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1684, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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2
[SID4263427]
EC50 3.261TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1684, Type: confirmatory]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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3
[SID4263427]
EC50 4.727TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1681, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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4
[SID4263427]
EC50 4.727TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1681, Type: confirmatory]NCOA2 protein [Homo sapiens] [gi:62201602]
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5
[SID4263427]
EC50 6.301TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1679, Type: confirmatory]nuclear receptor coactivator 1 [Homo sapiens] [gi:152112968]
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6
[SID4263427]
EC50 6.301TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists [AID1679, Type: confirmatory]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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7
[SID4263427]
Potency 26.6795qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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8
[SID4263427]
EC50 50A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhimurium identified in the primary screen [AID2253, Type: confirmatory]
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9
[SID4263427]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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10
[SID4263427]
Luminescence Microorganism Retest to Identify Inhibitors of the AI-2 Quorum Sensing System [AID2727, Type: screening]Alkanal monooxygenase alpha chain [gi:126509]
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11
[SID4263427]
Primary Antimicrobial Assay for E. coli BW25113 ∆tolC::kan Protocol for 384-well HTS [AID573, Type: screening]
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12
[SID4263427]
Antimicrobial Assay for E. coli BW25113 ∆tolC::kan - Dose Response [AID617, Type: confirmatory]
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13
[SID4263427]
Screen for Chemicals that Shorten Yeast Lifespan [AID804, Type: screening]
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14
[SID4263427]
Screening for Modulators of Post-Golgi Transport, Control Strain [AID738, Type: screening]
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15
[SID4263427]
Leishmania major promastigote HTS [AID1063, Type: screening]
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16
[SID4263427]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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17
[SID4263427]
CYP2C19 Assay [AID778, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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18
[SID4263427]
Dose Response Assay for S1P3 Antagonists [AID484, Type: confirmatory]sphingosine 1-phosphate receptor 3 [Homo sapiens] [gi:38788193]
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19
[SID4263427]
Primary HTS Assay for S1P3 Antagonists [AID485, Type: screening]sphingosine 1-phosphate receptor 3 [Homo sapiens] [gi:38788193]
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20
[SID4263427]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID731, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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21
[SID4263427]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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22
[SID4263427]
Confirmation biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1301, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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23
[SID4263427]
Confirmation biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1297, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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24
[SID4263427]
Confirmation biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1300, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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25
[SID4263427]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1032, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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26
[SID4263427]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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27
[SID4263427]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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28
[SID4263427]
uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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29
[SID4263427]
Confirmation biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1300, Type: screening]nuclear receptor coactivator 1 [Homo sapiens] [gi:152112968]
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30
[SID4263427]
Luminescence Microorganism Retest to Identify Inhibitors of the AI-2 Quorum Sensing System [AID2727, Type: screening]LuxR [Vibrio harveyi] [gi:107933356]
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31
[SID4263427]
Confirmation biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1301, Type: screening]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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32
[SID4263427]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID731, Type: screening]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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33
[SID4263427]
Luminescence Microorganism-Based Retest to Identify Modulators of the AI-2 Quorum Sensing System [AID2736, Type: screening]Chain A, Crystal Structure Of The Apo Form Of Vibrio Harveyi Luxp Complexed With The Periplasmic Domain Of Luxq [gi:67463988]
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34
[SID4263427]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]Chain A, Crystal Structure Of The Apo Form Of Vibrio Harveyi Luxp Complexed With The Periplasmic Domain Of Luxq [gi:67463988]
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35
[SID4263427]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]Chain B, Crystal Structure Of The Apo Form Of Vibrio Harveyi Luxp Complexed With The Periplasmic Domain Of Luxq [gi:67463989]
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36
[SID4263427]
Luminescence Microorganism-Based Retest to Identify Modulators of the AI-2 Quorum Sensing System [AID2736, Type: screening]Chain B, Crystal Structure Of The Apo Form Of Vibrio Harveyi Luxp Complexed With The Periplasmic Domain Of Luxq [gi:67463989]
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37
[SID4263427]
Confirmation biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1297, Type: screening]NCOA2 protein [Homo sapiens] [gi:62201602]
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38
[SID4263427]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1032, Type: screening]NCOA2 protein [Homo sapiens] [gi:62201602]
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39
[SID4263427]
Luminescence Microorganism Retest to Identify Inhibitors of the AI-2 Quorum Sensing System [AID2727, Type: screening]Phosphorelay protein LuxU [gi:160409944]
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40
[SID4263427]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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41
[SID4263427]
Plate Read Microorganism-Based Primary HTS to Identify Modulators of the AI-2 Quorum Sensing System [AID2094, Type: screening]LuxS [Vibrio harveyi] [gi:166202459]
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42
[SID4263427]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-gamma1). [AID720700, Type: screening]Phospholipase C, gamma 1 [Homo sapiens] [gi:223459640]
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43
[SID4263427]
Luminescence Microorganism Retest to Identify Inhibitors of the AI-2 Quorum Sensing System [AID2727, Type: screening]Luminescence regulatory protein LuxO [gi:160409943]
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44
[SID4263427]
Luminescence Microorganism-Based Retest to Identify Modulators of the AI-2 Quorum Sensing System [AID2736, Type: screening]LuxS [Vibrio harveyi] [gi:166202459]
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45
[SID4263427]
Potency qHTS for Inhibitors of KCHN2 3.1: Mutant qHTS [AID720553, Type: confirmatory]potassium voltage-gated channel subfamily H member 2 isoform a [Homo sapiens] [gi:342840031]
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46
[SID4263427]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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47
[SID4263427]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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48
[SID4263427]
Potency 2.5119qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
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49
[SID4263427]
Potency 5.6234qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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50
[SID4263427]
Potency 14.1254qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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