1-Deoxynojirimycin (CID 29435) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(94)
 
 
Inactive(36)
 
 
Inconclusive(5)
 
 
Unspecified(137)
 
 
Top Targets:
GH31 MGAM SI..(26)
 
 
 
 
Glyco hydro 3..(5)
 
 
 
Glyco hydro 1(5)
 
 
 
Alpha L fucos(3)
 
 
Glyco hydro 3..(3)
 
 
BioAssay Types:
Literature(219)
 
 
 
 
Confirmatory(25)
 
 
 
 
Screening(4)
 
 
BioActivity Types:
IC50(120)
 
 
 
 
Potency(25)
 
 
 
 
Ki(21)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 271    Data Row: 272   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103278185]
Ki 0.014Competitive Inhibition constant on rice alpha Glucosidase at pH 6.0 [AID220747, Type: other]
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2
[SID103278185]
Ki 0.024Tested in vitro for the inhibition constant against rat small intestinal sucrase [AID208987, Type: other]
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3
[SID103278185]
IC50 0.03Inhibitory concentration against rice alpha-glucosidase [AID240928, Type: Literature]
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4
[SID103278185]
IC50 0.03Inhibition of rice alpha glucosidase [AID437996, Type: Literature]
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5
[SID103278185]
IC50 0.03Inhibition of rice alpha-glucosidase assessed as production of D-glucose using maltose as substrate after 10 to 30 mins by spectrophotometry [AID613055, Type: Literature]
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6
[SID26752140]
Potency 0.0366Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase Using an Alternate Red Fluorescent Susbtrate [AID2110, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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7
[SID26752140]
Potency 0.0366Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase Using an Alternate Red Fluorescent Susbtrate [AID2110, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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8
[SID26752140]
Potency 0.0366Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase Using an Alternate Red Fluorescent Susbtrate [AID2110, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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9
[SID26752140]
Potency 0.0366Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase [AID2115, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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10
[SID26752140]
Potency 0.0366Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase [AID2115, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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11
[SID26752140]
Potency 0.0366Confirmation of Inhibitors and Activators of Purified Human alpha-Glucosidase [AID2115, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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12
[SID103278185]
IC50 0.04Inhibitory concentration against human alpha-glucosidase [AID240862, Type: Literature]Maltase-glucoamylase, intestinal [gi:215274260]
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13
[SID103278185]
IC50 0.05Inhibition of rice alpha-glucosidase assessed as D-glucose release after 10 mins by Glucose B-test [AID397842, Type: Literature]
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14
[SID103278185]
IC50 0.05Inhibitory activity against alpha-Glucosidase from rice [AID240826, Type: Literature]
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15
[SID26752140]
Potency 0.0517Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2113, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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16
[SID26752140]
Potency 0.0517Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2113, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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17
[SID26752140]
Potency 0.0517Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2113, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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18
[SID103278185]
IC50 0.06Inhibition of maltase in human Caco-2 cell model system after 2 hrs [AID342811, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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19
[SID103278185]
IC50 0.06Inhibition of maltase in human Caco-2 cell model system after 2 hrs [AID342811, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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20
[SID103278185]
IC50 0.06Inhibition of maltase in human Caco-2 cell model system after 2 hrs [AID342811, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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21
[SID26752140]
Potency 0.0651Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate Using an Alternate Red Fluorescent Susbtrate [AID2111, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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22
[SID26752140]
Potency 0.0651Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate Using an Alternate Red Fluorescent Susbtrate [AID2111, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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23
[SID26752140]
Potency 0.0651Confirmation of Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate Using an Alternate Red Fluorescent Susbtrate [AID2111, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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24
[SID103278185]
IC50 0.13Inhibition of rat intestinal brush border membrane maltase [AID342793, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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25
[SID103278185]
Ki 0.15Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase [AID37275, Type: other]
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26
[SID103278185]
Ki 0.16Competitive Inhibition constant on rice alpha Glucosidase at pH 5.0 [AID220746, Type: other]
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27
[SID103278185]
IC50 0.16Inhibition of rat intestinal brush border membrane isomaltase [AID342795, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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28
[SID103278185]
IC50 0.19Inhibition of rabbit muscle amylo-1,6-glucosidase [AID342805, Type: Literature]Glycogen debranching enzyme [gi:544379]
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29
[SID103278185]
IC50 0.21Inhibition of rat intestinal brush border membrane sucrase [AID342797, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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30
[SID103278185]
IC50 0.21Inhibition of Sucrase in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method [AID208985, Type: Literature]
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31
[SID103278185]
IC50 0.21Inhibitory activity against rat intestinal sucrase using disaccharide [AID241686, Type: Literature]
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32
[SID103278185]
IC50 0.3Inhibitory activity against rat intestinal isomaltase using disaccharide [AID241781, Type: Literature]
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33
[SID103278185]
IC50 0.3Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method [AID91639, Type: Literature]
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34
[SID103278185]
IC50 0.36Inhibition of Glycosidases (maltase) in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method [AID104667, Type: Literature]
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35
[SID103278185]
IC50 0.36Inhibitory activity against rat intestinal maltase using disaccharide [AID241685, Type: Literature]
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36
[SID103278185]
IC50 0.36Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test [AID397844, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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37
[SID103278185]
IC50 0.4Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test [AID397845, Type: Literature]Lysosomal alpha-glucosidase [gi:81885339]
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38
[SID103278185]
IC50 0.4Inhibition of lysosomal Alpha-Glucosidase II in rat liver [AID36809, Type: Literature]
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39
[SID103278185]
IC50 0.45Inhibition of Bacillus stearothermophilus alpha-glucosidase assessed as p-nitrophenol release by colorimetry [AID467032, Type: Literature]
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40
[SID103278185]
IC50 0.5Inhibition of Saccharomyces cerevisiae alpha glucosidase [AID437997, Type: Literature]
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41
[SID103278185]
IC50 0.51Inhibition of rat intestinal sucrase assessed as production of p-nitrophenol at by spectrophotometry [AID613048, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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42
[SID103278185]
IC50 0.65Inhibitory concentration against rat intestinal maltase [AID240843, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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43
[SID103278185]
IC50 0.65Inhibition of rat intestinal isomaltase assessed as production of p-nitrophenol at by spectrophotometry [AID613047, Type: Literature]Sucrase-isomaltase, intestinal [gi:1351132]
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44
[SID103278185]
IC50 0.65Inhibition of Bacillus stearothermophilus alpha glucosidase [AID437998, Type: Literature]
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45
[SID103278185]
IC50 0.65Inhibition of rat intestinal maltase assessed as production of D-glucose using maltose as substrate after 10 to 30 mins by spectrophotometry [AID613046, Type: Literature]
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46
[SID103278185]
IC50 1Inhibition of human lysosomal alpha-glucosidase [AID342799, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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47
[SID103278185]
IC50 1Inhibition of human lysosomal alpha-glucosidase [AID342799, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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48
[SID103278185]
IC50 1Inhibition of human lysosomal alpha-glucosidase [AID342799, Type: Literature]Lysosomal alpha-glucosidase [gi:317373572]
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49
[SID103278185]
Ki 1.3Competitive Inhibitory activity against Endoplasmic reticulum Alpha-Glucosidase II [AID36810, Type: Literature]
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50
[SID103278185]
IC50 1.3Tested for competitive inhibition of endoplasmic reticulum alpha-glucosidase II. [AID37439, Type: Literature]
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