SMR000197380 (CID 2928562) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(47)
 
 
Inactive(594)
 
 
Inconclusive(40)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
alkPPc(12)
 
 
G-alpha(11)
 
 
 
 
Bcl-2 like(10)
 
 
 
7TM GPCR Srsx(9)
 
 
BioAssay Types:
Screening(475)
 
 
 
 
 
Confirmatory(184)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(131)
 
 
 
 
 
IC50(39)
 
 
 
EC50(8)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 679    Data Row: 684   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17414670]
Potency 2.8184qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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2
[SID17414670]
Potency 2.8184qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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3
[SID17414670]
Potency 3.5481qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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4
[SID17414670]
Potency 3.5481qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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5
[SID17414670]
Potency 6.3096qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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6
[SID17414670]
Potency 6.3096qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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7
[SID17414670]
Potency 10qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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8
[SID17414670]
Potency 15.8489qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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9
[SID17414670]
Potency 19.9526qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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10
[SID17414670]
Potency 19.9526qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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11
[SID17414670]
Potency 19.9526qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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12
[SID17414670]
Potency 22.3872qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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13
[SID17414670]
Potency 22.3872qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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14
[SID17414670]
Potency 22.3872qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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15
[SID17414670]
Potency 22.3872qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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16
[SID17414670]
Potency 25.1189qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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17
[SID17414670]
Potency 25.1189qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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18
[SID17414670]
Potency 28.1838qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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19
[SID17414670]
Potency 28.1838qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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20
[SID17414670]
Potency 31.6228qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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21
[SID17414670]
Potency 31.6228qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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22
[SID17414670]
Potency 39.8107qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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23
[SID17414670]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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24
[SID17414670]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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25
[SID17414670]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH; PLA2G7) [AID463230, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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26
[SID17414670]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH; PLA2G7) [AID463230, Type: screening]PLA2G7 gene product [Homo sapiens] [gi:270133071]
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27
[SID17414670]
 Inhibitors of Cav3 T-type Calcium Channels: Primary Screen [AID449739, Type: screening]voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] [gi:53832009]
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28
[SID17414670]
 Inhibitors of Cav3 T-type Calcium Channels: Primary Screen [AID449739, Type: screening]voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] [gi:53832009]
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29
[SID17414670]
 Inhibitors of Cav3 T-type Calcium Channels: Primary Screen [AID449739, Type: screening]voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] [gi:53832009]
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30
[SID17414670]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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31
[SID17414670]
 Luminescence-based biochemical high throughput validation assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) [AID493027, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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32
[SID17414670]
 Luminescence-based biochemical high throughput validation assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID493035, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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33
[SID17414670]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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34
[SID17414670]
 KCNK9 specificity screen for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID2329, Type: screening]KCNK9 gene product [Homo sapiens] [gi:7706135]
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35
[SID17414670]
 Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK9 [AID488922, Type: screening]KCNK9 gene product [Homo sapiens] [gi:7706135]
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36
[SID17414670]
 Second counter screen for compounds that modulate the two-pore domain potassium channel (KCNK9) [AID492997, Type: screening]KCNK9 gene product [Homo sapiens] [gi:7706135]
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37
[SID17414670]
 Confirmatory screen for identification of compounds that inhibit the two-pore domain potassium channel (KCNK9) [AID492992, Type: screening]KCNK9 gene product [Homo sapiens] [gi:7706135]
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38
[SID17414670]
 uHTS Colorimetric assay for identification of inhibitors of Scp-1 [AID493091, Type: screening]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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39
[SID17414670]
 Confirmatory screen for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID2032, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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40
[SID17414670]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. [AID1439, Type: screening]RGS7 [Homo sapiens] [gi:1166512]
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41
[SID17414670]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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42
[SID17414670]
 Counterscreen for inhibitors of PP5: fluorescence-based biochemical high throughput primary assay to identify inhibitors of Protein Phosphatase 1 (PP1). [AID2235, Type: screening]PPP1CA gene product [Homo sapiens] [gi:56790945]
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43
[SID17414670]
 Primary biochemical high-throughput screening assay for inhibitors of Focal Adhesion Kinase (FAK) [AID727, Type: screening]Focal adhesion kinase 1 [gi:3183518]
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44
[SID17414670]
 Primary biochemical high-throughput screening assay for inhibitors of Focal Adhesion Kinase (FAK) [AID727, Type: screening]Focal adhesion kinase 1 [gi:3183518]
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45
[SID17414670]
 Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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46
[SID17414670]
 Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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47
[SID17414670]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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48
[SID17414670]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ2 potassium channels [AID2156, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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49
[SID17414670]
 uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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50
[SID17414670]
 Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
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