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TCMDC-123650 (CID 2920571) - Compound BioActivity Data
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BioActivity Outcomes:
Active(57)
 
 
Inactive(666)
 
 
Inconclusive(39)
 
 
Unspecified(14)
 
 
Top Targets:
7tm 4(45)
 
 
 
Bcl-2 like(12)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(497)
 
 
 
 
Confirmatory(228)
 
 
 
 
 
Literature(29)
 
 
 
 
 
BioActivity Types:
Potency(160)
 
 
 
 
 
IC50(41)
 
 
 
 
EC50(21)
 
 
 
 
 
AC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 695    Data Row: 776   Total Pages: 39   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24804137]
AbsAC35_uM 0.185Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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2
[SID24804137]
AbsAC35_uM 0.484Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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3
[SID24804137]
EC50 0.56Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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4
[SID103664738]
CC50 0.72Cytotoxicity against human LNCAP cells assessed as inhibition of cell proliferation after 72 hrs by MTT assay [AID728117, Type: Literature]
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5
[SID24804137]
EC50 0.788Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole [AID2423, Type: confirmatory]heat shock protein 90 [Candida albicans] [gi:994798]
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6
[SID103664738]
IC50 1Inhibition of human platelet-type N-terminally His6-tagged 12-lipoxygenase assessed as conjugated diene product formation using arachidonic acid by UV-vis spectrophotometer analysis [AID611382, Type: Literature]Arachidonate 12-lipoxygenase, 12S-type [gi:125987838]
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7
[SID85736356]
Potency 1Cuvette-Based Assay for Inhibitors of 12-hLO (12-human lipoxygenase): 8HQ Series - Round 1 [AID2163, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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8
[SID24804137]
AC50_uM 1.31Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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9
[SID24804137]
Potency 1.4125qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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10
[SID24804137]
EC50 1.967Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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11
[SID24804137]
Potency 2.5929A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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12
[SID24804137]
Potency 2.8184VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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13
[SID24804137]
AbsAC1000_uM 2.994In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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14
[SID24804137]
AC50_uM 3.57Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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15
[SID24804137]
Potency 3.6626qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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16
[SID24804137]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID103664738]
IC50 4Inhibition of HIV-1 His6-tagged integrase interaction to FLAG-tagged LEDGF/p75 preincubated for 30 mins prior to LEDGF/p75 addition measured after 60 mins by alphascreen assay [AID728118, Type: Literature]
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18
[SID85736356]
Potency 5.0119Confirmation qHTS Assay for Inhibitors of 12-hLO (12-human lipoxygenase) [AID2162, Type: confirmatory]arachidonate 12-lipoxygenase, 12S-type [Homo sapiens] [gi:154426292]
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19
[SID24804137]
Potency 6.3096qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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20
[SID85736356]
Potency 6.3096Confirmation qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2677, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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