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cyclothiazide (CID 2910) - Compound BioActivity Data
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BioActivity Outcomes:
Active(38)
 
 
Inactive(775)
 
 
Inconclusive(53)
 
 
Unspecified(45)
 
 
Top Targets:
7tm 4(43)
 
 
 
NR LBD ER(8)
 
 
Geminin(8)
 
 
Pyr redox dim(8)
 
 
NR LBD PPAR(8)
 
 
 
BioAssay Types:
Confirmatory(349)
 
 
 
 
 
Screening(341)
 
 
Literature(144)
 
 
 
 
 
Summary(25)
 
 
BioActivity Types:
Potency(352)
 
 
 
 
 
EC50(20)
 
 
 
 
IC50(12)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 736    Data Row: 911   Total Pages: 46   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103249003]
EC50 1Agonist activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes [AID477135, Type: Literature]
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2
[SID103249003]
EC50 2Activity at recombinant GluA1 receptor flip isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on 10 uM glutamate-induced current by voltage-clamp electrophysiological assay [AID477545, Type: Literature]
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3
[SID103249003]
EC50 2.24Activity at human recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM staining-based fluorescence assay [AID477252, Type: Literature]Glutamate receptor 2 [gi:23831146]
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4
[SID103249003]
EC50 3.8Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells [AID223222, Type: Literature]
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5
[SID103249003]
EC50 3.8Activity against human GLUR4 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assay [AID270081, Type: Literature]Glutamate receptor 4 [gi:218512059]
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6
[SID103249003]
EC50 3.91Activity at human recombinant GluA4 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM staining-based fluorescence assay [AID477255, Type: Literature]
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7
[SID103249003]
EC50 5Activity at recombinant GluA2A4 receptor flip isoform expressed in Xenopus oocytes assessed as effect on 300 uM glutamate-induced current [AID477242, Type: Literature]
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8
[SID103249003]
EC50 5.9Activity at recombinant GluA4 receptor flip isoform expressed in Xenopus oocytes assessed as effect on 300 uM glutamate-induced current [AID477239, Type: Literature]
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9
[SID103249003]
IC50 6.1Inhibition of binding to AMPA receptor from rat cerebral cortex [AID92496, Type: Literature]
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10
[SID103249003]
EC50 6.6Activity at recombinant GluA1A2 receptor flip isoform expressed in Xenopus oocytes assessed as effect on 300 uM glutamate-induced current [AID477240, Type: Literature]
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11
[SID103249003]
EC50 7.1Activity at Wistar rat cortex AMPA receptor expressed in Xenopus laevis oocytes assessed as effect on (S)-AMPA-induced current [AID291180, Type: Literature]
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12
[SID103249003]
EC50 7.6Agonist activity at rat flip iGluR2(Q) expressed in Xenopus laevis oocytes by whole cell patch-clamp method [AID391457, Type: Literature]Glutamate receptor 2 [gi:3287964]
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13
[SID103249003]
EC50 10Activity at recombinant GluA1 receptor flop isoform expressed in Xenopus oocytes co-expressing gamma2-TARP assessed as effect on 10 uM glutamate-induced current by voltage-clamp electrophysiological assay [AID477546, Type: Literature]
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14
[SID50104549]
Potency 11.2202qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2353, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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15
[SID103249003]
EC50 13.7Activity at human recombinant GluA3 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM staining-based fluorescence assay [AID477254, Type: Literature]Glutamate receptor 3 [gi:77416864]
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16
[SID103249003]
EC50 19.8Activity at human recombinant GluA1 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM staining-based fluorescence assay [AID477251, Type: Literature]Glutamate receptor 1 [gi:116242505]
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17
[SID103249003]
Thiazide-sensitive sodium-chloride cotransporter inhibitor [AID742822, Type: other]Solute carrier family 12 member 3 [gi:313104194]
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18
[SID103249003]
Potentiation of AMPA receptor transmission in Xenopus oocytes injected with poly {A+) mRNA from rat [AID31453, Type: other]Glutamate receptor 1 [gi:97536283]
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19
[SID103249003]
Potentiation of AMPA receptor transmission in Xenopus oocytes injected with poly {A+) mRNA from rat [AID31453, Type: other]Glutamate receptor 2 [gi:3287964]
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20
[SID103249003]
Agonist activity at AMPA receptor in rat cortical neurons assessed as change in increase in AMPA current [AID536780, Type: Literature]
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