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BioActivity Data for Compound Cyclophosphamide (CID 2907)

BioActivity Outcomes:
Active(90)
 
 
Inactive(363)
 
 
Inconclusive(13)
 
 
Unspecified(2276)
 
 
Top Targets:
7tm 4(36)
 
 
 
p450(18)
 
 
 
 
NAD binding 8(6)
 
 
 
Pyr redox dim(5)
 
 
 
Geminin(4)
 
 
BioAssay Types:
Confirmatory(404)
 
 
 
 
 
Literature(392)
 
 
 
 
 
Screening(13)
 
 
Summary(1)
 
 
BioAssay Categories:
Biochemical(145)
 
 
 
 
Cell-based(220)
 
 
 
 
Toxicity(1869)
 
 
 
 
ADME(92)
 
 
 
 
In vitro(139)
 
 
 
 
In vivo(1913)
 
 
 
 
 
BioActivity Types:
Potency(189)
 
 
 
 
 
IC50(135)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2688    Data Row: 2742   Total Pages: 138   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID90341534]
Potency 0.006qHTS Validation Assay for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID488953, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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2
[SID103171472]
IC50 0.09Cytotoxicity against Homo sapiens (human) MDA-MB-231 cells after 48 hr by MTT assay [AID1085426, Type: confirmatory]
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3
[SID103171472]
IC50 0.15Cytotoxicity against Homo sapiens (human) K562 cells after 48 hr by MTT assay [AID1085429, Type: confirmatory]
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4
[SID103171472]
IC50 0.153Antiproliferative activity against Homo sapiens (human) K562 cells after 48 hr by MTT assay [AID1083866, Type: confirmatory]
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5
[SID103171472]
IC50 0.16Cytotoxicity against Homo sapiens (human) MCF7 cells after 48 hr by trypan blue assay [AID1095201, Type: confirmatory]
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6
[SID103171472]
IC50 0.24Cytotoxicity against Homo sapiens (human) HepG2 cells after 48 hr by MTT assay [AID1085427, Type: confirmatory]
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7
[SID103171472]
IC50 8.79Cytotoxicity against human HL60 cells by MTT assay [AID526308, Type: Literature]
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8
[SID90341534]
Potency 17.7828qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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9
[SID103171472]
LC50 37.6In vitro cytotoxicity was evaluated in mouse embryo BALB/c 3T3 cells [AID3372, Type: Literature]
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10
[SID103171472]
LC50 37.6In vitro cytotoxicity in BALB/c3T3 mouse embryo fibroblasts. [AID41575, Type: Literature]
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11
[SID103171472]
IC50 37.6In vitro cytotoxicity against BALB/c 3T3 cells [AID41567, Type: Literature]
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12
[SID103171472]
Induction of Escherichia coli pBluescript 2 KS+ DNA cleavage at 10 mM by gel electrophoresis [AID408577, Type: Literature]
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13
[SID87150]
NCI In Vivo Anticancer Drug Screen. Data for tumor model Lieberman Plasma Cell No. 1 (LPC-1) (intraperitoneal) in unknown mice [AID344, Type: other]
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14
[SID87150]
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia resistant to A Terephthalanilide; NSC 38280 (intraperitoneal) in B6D2F1 (BDF1) mice [AID338, Type: other]
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15
[SID87150]
NCI In Vivo Anticancer Drug Screen. Data for tumor model Reticulum Cell Sarcoma (Kelley Mouse) (intraperitoneal) in CD2F1 (CDF1) mice [AID340, Type: other]
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16
[SID103171472]
Immunosuppressive activity against MAV-1 infected BALB/c mouse assessed as B cells suppression at 100 mg/kg, ip treated 8 days before infection for 4 weeks measured 14 days post infection by flow cytometry [AID542221, Type: Literature]
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17
[SID103171472]
Immunosuppressive activity against MAV-1 infected BALB/c mouse assessed as effect on leukocyte proliferation by T-cell stimulus alphaCD3 at 100 mg/kg, ip treated 8 days before infection by flow cytometry [AID542222, Type: Literature]
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18
[SID103171472]
Immunosuppressive activity against MAV-1 infected BALB/c mouse assessed as effect on parenchymal inflammation in liver at 100 mg/kg, ip treated 8 days before infection for 2 weeks by flow cytometry [AID542422, Type: Literature]
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19
[SID87150]
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intracerebral) in CD2F1 (CDF1) mice [AID334, Type: other]
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20
[SID87150]
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia resistant to Vincristine; NSC 67574 (intraperitoneal) in B6D2F1 (BDF1) mice [AID336, Type: other]
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