Isocycloheximide (CID 2900) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(9)
 
 
Inactive(6)
 
 
Unspecified(2)
 
 
Top Targets:
HpcH HpaI(1)
 
 
BioAssay Types:
Confirmatory(9)
 
 
 
BioActivity Types:
Potency(9)
 
 
 
EC50(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 13    Data Row: 17   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103713949]
EC50 0.02165NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: other]
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2
[SID103713949]
EC50 0.0675NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: other]
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3
[SID103714034]
EC50 0.1526NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: other]
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4
[SID103713949]
CC50 0.3043NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: other]
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5
[SID103714034]
EC50 0.366NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: other]
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6
[SID124893560]
Potency 1.0859qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
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7
[SID124893560]
Potency 1.9144Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 16 hrs) [AID651712, Type: confirmatory]
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8
[SID103714034]
CC50 2.144NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: other]
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9
[SID124893560]
Potency 17.0619Cell Proliferation Assay against the TMD8 Cell Line (Caspase readout at 8 hrs) [AID651713, Type: confirmatory]
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10
[SID103714034]
 NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. [AID449706, Type: other]
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11
[SID103713949]
 NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. [AID449706, Type: other]
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12
[SID124893560]
Potency 0.0605Cell Proliferation Assay against the HBL1 Cell Line [AID651646, Type: confirmatory]
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13
[SID124893560]
Potency 1.7062Cell Proliferation Assay against a hMSC Cell Line [AID651696, Type: confirmatory]
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14
[SID124893560]
Potency Cell Proliferation Assay against the TMD8 Cell Line [AID651645, Type: confirmatory]
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15
[SID124893560]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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16
[SID124893560]
Potency qHTS Assay for Identification of Small Molecule Agonists for NFkB Signaling Pathway. [AID624478, Type: confirmatory]
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17
[SID124893560]
Potency Cytotoxicity counterscreen for NFkB agonists and antagonists [AID624476, Type: confirmatory]
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