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cyclobenzaprine (CID 2895) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(21)
 
 
Inactive(353)
 
 
Inconclusive(74)
 
 
Unspecified(33)
 
 
Top Targets:
p450(27)
 
 
 
 
HSD10-like SD..(12)
 
 
NR LBD GR(6)
 
 
BRCT(6)
 
 
HIF-1a CTAD(6)
 
 
BioAssay Types:
Confirmatory(332)
 
 
 
 
Literature(93)
 
 
 
 
 
Screening(14)
 
 
BioActivity Types:
Potency(258)
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 235    Data Row: 481   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID11110649]
Potency 0.0316qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response [AID943, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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2
[SID11110649]
Potency 0.1122qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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3
[SID90340629]
Potency 1HTS Assay for Allosteric Agonists of the Human D1 Dopamine Receptor: Primary Screen for Antagonists [AID488983, Type: confirmatory]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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4
[SID11110650]
Potency 6.3096qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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5
[SID4253288]
Potency 6.5104qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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6
[SID11110649]
Potency 6.5104qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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7
[SID11110650]
Potency 6.5104qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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8
[SID50108641]
Potency 6.5104qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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9
[SID50111010]
Potency 6.5104qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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10
[SID90340629]
Potency 6.5104qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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11
[SID90340629]
Potency 8.1961qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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12
[SID11110650]
Potency 11.2202qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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13
[SID11110650]
Cytochrome panel assay with activity outcomes [AID1851_2, Type: other]cytochrome P450 2D6 isoform 2 [Homo sapiens] [gi:68509921]
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14
[SID11110650]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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15
[SID4253288]
NFAT Signaling Pathway [AID444, Type: confirmatory]
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16
[SID4253288]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_3, Type: Literature]
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17
[SID4253288]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_19, Type: Literature]
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18
[SID4253288]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_53, Type: Literature]
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19
[SID4253288]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_57, Type: Literature]
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20
[SID4253288]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_55, Type: Literature]
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21
[SID85209719]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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22
[SID103189735]
Substrate of human UDP-glucuronosyltransferase UGT1A4 [AID589070, Type: other]UDP-glucuronosyltransferase 1-4 [gi:136731]
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23
[SID11110650]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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24
[SID103189735]
Evaluated for the antiarrhythmic activity in conscious dogs after myocardial infarction by observing 50% reduction in ectopic rate. . [AID58617, Type: Literature]
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25
[SID103189735]
Evaluated for the antiarrhythmic activity in conscious dogs after myocardial infarction by observing for conversion to sinus rhythm. [AID58619, Type: Literature]
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26
[SID103189735]
Lipophilicity, log D at pH7.4 [AID298031, Type: Literature]
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27
[SID103189735]
Acid dissociation constant, pKa of the compound [AID298032, Type: Literature]
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28
[SID103189735]
Lipophilicity, log D at pH 7.4 by liquid chromatography [AID395324, Type: Literature]
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29
[SID103189735]
Lipophilicity, log P by microemulsion electrokinetic chromatography [AID395325, Type: Literature]
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30
[SID103189735]
Dissociation constant, pKa by capillary electrophoresis [AID395327, Type: Literature]
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31
[SID4253288]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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32
[SID11110649]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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33
[SID4253288]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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34
[SID103189735]
FDA HLAED, liver enzyme composite activity [AID588214, Type: Literature]
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35
[SID103189735]
FDA HLAED, alkaline phosphatase increase [AID588215, Type: Literature]
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36
[SID103189735]
FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase [AID588216, Type: Literature]
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37
[SID103189735]
FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase [AID588217, Type: Literature]
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38
[SID103189735]
FDA HLAED, lactate dehydrogenase (LDH) increase [AID588218, Type: Literature]
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39
[SID103189735]
FDA HLAED, gamma-glutamyl transferase (GGT) increase [AID588219, Type: Literature]
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40
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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41
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis [AID625280, Type: Literature]
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42
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
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43
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
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44
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests [AID625283, Type: Literature]
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45
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure [AID625284, Type: Literature]
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46
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis [AID625285, Type: Literature]
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47
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis [AID625286, Type: Literature]
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48
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly [AID625287, Type: Literature]
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49
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice [AID625288, Type: Literature]
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50
[SID103189735]
Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease [AID625289, Type: Literature]
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