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N-(2,5-dimethylphenyl)bicyclo[2.2.1]heptane-3-carboxamide (CID 2886682) - Compound BioActivity Data
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BioActivity Outcomes:
Active(19)
 
 
Inactive(538)
 
 
Inconclusive(12)
 
 
Unspecified(1)
 
 
Top Targets:
KCNQ channel(24)
 
 
 
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(379)
 
 
 
 
Confirmatory(175)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(118)
 
 
 
 
IC50(31)
 
 
EC50(24)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 513    Data Row: 570   Total Pages: 29   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103073347]
EC50 0.39561Mode of action assay-Dose response assay for KCNQ2 activators in the KCNQ2/KCNQ3 co-expressing cells on automated patch clamp [AID493039, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 3 [Rattus norvegicus] [gi:15826856]
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2
[SID103073347]
EC50 0.39561Mode of action assay-Dose response assay for KCNQ2 activators in the KCNQ2/KCNQ3 co-expressing cells on automated patch clamp [AID493039, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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3
[SID103073347]
EC50 0.40215Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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4
[SID103073347]
EC50 1.05161Mode of action assay-Confirmatory dose response assay for compounds that activate KCNQ2 potassium channels [AID493037, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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5
[SID103073347]
EC50 1.6257Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp [AID493043, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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6
[SID103073347]
EC50 1.6257Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp [AID493043, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 4 isoform a [Homo sapiens] [gi:26638653]
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7
[SID103073347]
EC50 2.64Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux [AID504416, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 4 isoform a [Homo sapiens] [gi:26638653]
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8
[SID103073347]
EC50 2.64Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux [AID504416, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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9
[SID103073347]
EC50 2.6844Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
View
10
[SID103073347]
EC50 2.6844Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
11
[SID103073347]
EC50 2.6844Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]potassium voltage-gated channel subfamily E member 1 [Homo sapiens] [gi:189095237]
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12
[SID103073347]
EC50 5.03434Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1 expressing cells on automated patch clamp [AID493044, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
View
13
[SID103073347]
EC50 5.03434Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1 expressing cells on automated patch clamp [AID493044, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
View
14
[SID47198546]
Confirmatory screen for compounds that potentiate KCNQ2 potassium channels [AID2287, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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15
[SID47198546]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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16
[SID47198546]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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17
[SID47198546]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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18
[SID47198546]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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19
[SID47198546]
Specificity screen against KCNQ1 for compounds that potentiate KCNQ2 potassium channels [AID2283, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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20
[SID47198546]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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