N-(2,5-dimethylphenyl)bicyclo[2.2.1]heptane-3-carboxamide (CID 2886682) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(455)
 
 
Inconclusive(7)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
KCNQ channel(17)
 
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(322)
 
 
 
Confirmatory(144)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(99)
 
 
 
 
IC50(28)
 
 
EC50(15)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 475    Data Row: 475   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103073347]
EC50 0.39561Mode of action assay-Dose response assay for KCNQ2 activators in the KCNQ2/KCNQ3 co-expressing cells on automated patch clamp [AID493039, Type: confirmatory]potassium voltage-gated channel subfamily KQT member 3 [Rattus norvegicus] [gi:15826856]
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2
[SID103073347]
EC50 0.40215Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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3
[SID103073347]
EC50 0.40215Mode of action assay-Dose response assay for compounds that activate KCNQ2 potassium channels on automated patch clamp [AID493038, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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4
[SID103073347]
EC50 1.05161Mode of action assay-Confirmatory dose response assay for compounds that activate KCNQ2 potassium channels [AID493037, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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5
[SID103073347]
EC50 1.05161Mode of action assay-Confirmatory dose response assay for compounds that activate KCNQ2 potassium channels [AID493037, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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6
[SID103073347]
EC50 1.6257Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp [AID493043, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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7
[SID103073347]
EC50 1.6257Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ4 expressing cells on automated patch clamp [AID493043, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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8
[SID103073347]
EC50 2.64Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux [AID504416, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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9
[SID103073347]
EC50 2.64Mode of action assay- Specificity dose response assay for the KCNQ2 activators in the KCNQ4 expressing cells by the Tl flux [AID504416, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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10
[SID103073347]
EC50 2.6844Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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11
[SID103073347]
EC50 2.6844Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1/KCNE1 expressing cells on automated patch clamp [AID493042, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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12
[SID103073347]
EC50 5.03434Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1 expressing cells on automated patch clamp [AID493044, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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13
[SID103073347]
EC50 5.03434Mode of action assay-Dose response assay for the identification of selective activators of KCNQ2 potassium channels in the KCNQ1 expressing cells on automated patch clamp [AID493044, Type: confirmatory]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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14
[SID47198546]
 Specificity screen against KCNQ1 for compounds that potentiate KCNQ2 potassium channels [AID2283, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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15
[SID47198546]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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16
[SID47198546]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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17
[SID47198546]
 Confirmatory screen for compounds that potentiate KCNQ2 potassium channels [AID2287, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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18
[SID47198546]
 Confirmatory screen for compounds that potentiate KCNQ2 potassium channels [AID2287, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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19
[SID47198546]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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20
[SID47198546]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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21
[SID47198546]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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22
[SID47198546]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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23
[SID47198546]
Potency 79.4328HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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24
[SID47198546]
 uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COPS5 gene product [Homo sapiens] [gi:38027923]
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25
[SID47198546]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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26
[SID47198546]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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27
[SID47198546]
 Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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28
[SID47198546]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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29
[SID47198546]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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30
[SID47198546]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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31
[SID47198546]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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32
[SID47198546]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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33
[SID47198546]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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34
[SID47198546]
Potency qHTS of IL-2 Activators [AID652025, Type: confirmatory]Il2 gene product [Mus musculus] [gi:7110653]
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35
[SID47198546]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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36
[SID47198546]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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37
[SID47198546]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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38
[SID47198546]
 Counter screen for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID2105, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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39
[SID47198546]
 Specificity screen against Kir2.1 for compounds that potentiate KCNQ2 [AID2345, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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40
[SID47198546]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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41
[SID47198546]
 Confirmatory screen for compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID2032, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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42
[SID47198546]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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43
[SID47198546]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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44
[SID47198546]
 uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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45
[SID47198546]
 uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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46
[SID47198546]
IC50 Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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47
[SID47198546]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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48
[SID47198546]
 uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via a fluorescence intensity assay [AID588621, Type: screening]PTPN5 gene product [Homo sapiens] [gi:90652859]
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49
[SID47198546]
 Primary cell-based high-throughput screening for identification of compounds that activate/potentiate calcium-activated chloride channels (TMEM16A) [AID623877, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
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50
[SID47198546]
 Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
View