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4-cresol (CID 2879) - Compound BioActivity Data
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BioActivity Outcomes:
Active(6)
 
 
Inactive(620)
 
 
Inconclusive(57)
 
 
Unspecified(37)
 
 
Top Targets:
NR LBD PPAR(39)
 
 
 
NR LBD ER(37)
 
 
 
 
NR LBD AR(37)
 
 
 
NR LBD GR(22)
 
 
 
NR LBD TR(21)
 
 
 
BioAssay Types:
Confirmatory(508)
 
 
 
 
Summary(111)
 
 
 
Literature(31)
 
 
 
 
Screening(9)
 
 
 
BioActivity Types:
Potency(553)
 
 
 
 
IC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 356    Data Row: 720   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103179460]
IC50 0.00182Inhibition of acetylcholinesterase. [AID32248, Type: Literature]
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2
[SID103179460]
IC50 4.9IC50 against acetylcholinesterase; value ranges from 1-4900 nM. [AID32280, Type: Literature]
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3
[SID103179460]
Km 10Apparent Michaelis constant (Km) against Arylsulfotransferase (AST IV) [AID39219, Type: Literature]
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4
[SID144206791]
Potency-Replicate_1 26.6032qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID48415061]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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6
[SID48421963]
DSSTox (NCTRER) National Center for Toxicological Research Estrogen Receptor Binding Database [AID1204, Type: screening]
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7
[SID103179460]
IC50 290Tested for inhibition of ferrous salt/ascorbate induced lipidic peroxidation of membrane lipid of rat hepatocytes [AID248526, Type: Literature]
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8
[SID103179460]
IC50 290Antioxidant activity assessed as inhibition of TBARS production in ferrous salt/ascorbate-induced lipid peroxidation in Wistar rat liver microsomal membrane [AID264513, Type: Literature]
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9
[SID103179460]
IC50 3640Inhibitory activity on germination of Bacillus subtilis PCI219 spores was determined. [AID40623, Type: Literature]
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10
[SID103179460]
Inhibition of Bacillus subtilis PCI219 spore germination, expressed as log 1/I50 [AID40936, Type: Literature]
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11
[SID103179460]
Binding constant against bovine serum albumin [AID203473, Type: Literature]
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12
[SID103179460]
Ratio of kcat/Km determined for catalytic efficiency in sulfonation against AST IV [AID229377, Type: Literature]
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13
[SID103179460]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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14
[SID103179460]
Maximal velocity (Vmax) against Arylsulfotransferase (AST IV) [AID39220, Type: Literature]
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15
[SID103179460]
Calculated partition coefficient (clogP) [AID19211, Type: Literature]
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16
[SID103179460]
Aqueous solubility [AID19262, Type: Literature]
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17
[SID103179460]
Partition coefficient (logP) [AID23714, Type: Literature]
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18
[SID103179460]
Capacity ratio (log k'w) [AID23978, Type: Literature]
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19
[SID103179460]
Dissociation constant (pKa) [AID25611, Type: Literature]
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20
[SID103179460]
Partition coefficient (logD7.2) [AID26261, Type: Literature]
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21
[SID103179460]
Partition coefficient (logP) [AID26793, Type: Literature]
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22
[SID103179460]
Activity against caspase-mediated apoptosis in mouse L1210 cells at 0.1 mM [AID282833, Type: Literature]
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23
[SID103179460]
IC50 Cytotoxicity against mouse L1210 cells [AID282835, Type: Literature]
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24
[SID103179460]
Cytotoxicity against human HL60 cells [AID282836, Type: Literature]
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25
[SID103179460]
Cytotoxicity against human CCRF-CEM cells [AID282838, Type: Literature]
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26
[SID103179460]
Cytotoxicity against human CEM/VLB cells [AID282839, Type: Literature]
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27
[SID103179460]
Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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28
[SID103179460]
Lipophilicity, log P of the compound [AID385221, Type: Literature]
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29
[SID8149273]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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30
[SID8149273]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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31
[SID8149273]
Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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32
[SID8149273]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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33
[SID8149273]
Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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34
[SID8149273]
Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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35
[SID8149273]
Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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36
[SID8149273]
Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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37
[SID8149273]
Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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38
[SID8149273]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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39
[SID17389093]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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40
[SID24715061]
Basic StarGazer Assay on Human SULT1E1 [AID747, Type: other]estrogen sulfotransferase [Homo sapiens] [gi:4885617]
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41
[SID103179460]
Specific activity of expressed human recombinant UGT1A9 [AID624612, Type: Literature]UDP-glucuronosyltransferase 1-9 [gi:29839451]
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42
[SID103179460]
Specific activity of expressed human recombinant UGT1A6 [AID624609, Type: Literature]UDP-glucuronosyltransferase 1-6 [gi:29840832]
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43
[SID103179460]
Major substrate of human cytosolic sulfotransferase SULT1A1 [AID589057, Type: other]Sulfotransferase 1A1 [gi:313104286]
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44
[SID144206995]
Potency-Replicate_1 6.6824qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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45
[SID144206791]
Potency-Replicate_1 10.5909qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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46
[SID26747378]
Potency 22.3872qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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47
[SID144207600]
Potency-Replicate_1 25.5112qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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48
[SID144207600]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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49
[SID144207600]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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50
[SID144207600]
Ratio Potency (uM) qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743078, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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