BAS 00822693 (CID 2865685) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Inactive(17)
 
 
Top Targets:
DSPc(2)
 
 
Peptidase M27(2)
 
 
Rac1 like(2)
 
 
Ras like GTPa..(2)
 
 
ATLF(1)
 
 
BioAssay Types:
Confirmatory(14)
 
 
 
Screening(4)
 
 
BioActivity Types:
EC50(11)
 
 
 
IC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 18    Data Row: 18   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57578374]
EC50 10.162Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID2041, Type: confirmatory]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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2
[SID134964708]
EC50 20High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Lethal Factor protease, compounds from Powder Set 01 [AID624244, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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3
[SID134964708]
EC50 20High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, compounds from Powder Set 01 [AID624243, Type: confirmatory]botulinum neurotoxin type A [Clostridium botulinum A str. ATCC 3502] [gi:148378801]
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4
[SID134964708]
EC50 20High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, compounds from Powder Set 01 [AID624245, Type: confirmatory]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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5
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein [AID2019, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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6
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2020, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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7
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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8
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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9
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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10
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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11
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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12
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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13
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID2045, Type: confirmatory]Ras-related protein Rab-2 [gi:46577642]
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14
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2048, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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15
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 activated mutant [AID2048, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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16
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2055, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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17
[SID57578374]
EC50 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac1 wildtype [AID2055, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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18
[SID17454090]
IC50 MKP-3 in vitro HTS assay [AID425, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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19
[SID17454090]
IC50 MKP-3 in vitro HTS assay [AID425, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
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20
[SID17454090]
IC50 HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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21
[SID17454090]
IC50 HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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22
[SID17454090]
IC50 HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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23
[SID17454090]
IC50 High Throughput Screening Assay for Hsp70 Inhibitors [AID583, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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24
[SID17454090]
 High Throughput Screen for Inhibitors of ER Stress-induced Cell Death [AID1010, Type: screening]
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25
[SID8085194]
 HIV-1 RNase H Inhibition [AID372, Type: screening]Chain A, Solution Structure Of The Rnase H Domain Of The Hiv-1 Reverse Transcriptase In The Presence [gi:28949057]
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26
[SID17454090]
 HTS Colorimetric assay for the identification of compounds that inhibit VHR1 [AID1992, Type: screening]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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27
[SID17454090]
 HTS Colorimetric assay for the identification of compounds that inhibit VHR1 [AID1992, Type: screening]dual specificity protein phosphatase 3 [Homo sapiens] [gi:4758208]
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28
[SID17454090]
 Fluorescence Polarization Screen Assay for Bcl-B Phenotype Converters [AID1240, Type: screening]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
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29
[SID17454090]
 Fluorescence Polarization Screen Assay for Bcl-B Phenotype Converters [AID1240, Type: screening]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
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30
[SID17454090]
 Fluorescence Polarization Screen Assay for Bcl-B Phenotype Converters [AID1240, Type: screening]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
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