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SMR000070044 (CID 2859888) - Compound BioActivity Data
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BioActivity Outcomes:
Active(71)
 
 
Inactive(435)
 
 
Inconclusive(27)
 
 
Unspecified(1)
 
 
Top Targets:
alkPPc(18)
 
 
 
Bcl-2 like(15)
 
 
 
7TM GPCR Srx(14)
 
 
DSPc(13)
 
 
 
7TM GPCR Srsx(10)
 
 
BioAssay Types:
Screening(310)
 
 
 
 
Confirmatory(201)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(97)
 
 
 
 
 
IC50(59)
 
 
 
 
EC50(13)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 498    Data Row: 534   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4263567]
IC50 0.28HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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2
[SID4263567]
IC50 0.997393Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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3
[SID4263567]
IC50 1.0757High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 isoform 1 [Homo sapiens] [gi:27894344]
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4
[SID26513892]
IC50 2.18In Vitro HePTP Dose Response Colorimetric Assay for SAR Study [AID1059, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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5
[SID4263567]
Potency 3.1623qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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6
[SID4263567]
Potency 3.1623qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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7
[SID4263567]
Potency 3.1623qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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8
[SID4263567]
Potency 3.1623qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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9
[SID4263567]
Potency 3.9811qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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10
[SID4263567]
Potency 3.9811qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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11
[SID4263567]
Potency 3.9811qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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12
[SID4263567]
Absolute IC50 4.11Dose Response Confirmation for Small Molecule Inhibitors of Epstein-Barr Virus [AID1419, Type: confirmatory]BZLF2 [Human herpesvirus 4 type 2] [gi:139424501]
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13
[SID26513892]
IC50 5.56In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study [AID1072, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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14
[SID4263567]
Potency 6.3096qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
View
15
[SID26513892]
IC50_Mean 7.45Fluorescent secondary assay for dose-response confirmation of chemical inhibitors of HePTP [AID1077, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
View
16
[SID4263567]
Potency 7.9433qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
View
17
[SID4263567]
Potency 8.9125qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
View
18
[SID26513892]
IC50_Mean 9.873MKP-3 in vitro secondary assay for identification of redox-state modulating compounds [AID1054, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
View
19
[SID26513892]
IC50_Mean 9.873In Vitro MKP-3 Dose Response Assay for SAR Study [AID1055, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
View
20
[SID4263567]
Absolute IC50 10.2388Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID855, Type: confirmatory]eukaryotic translation initiation factor 4 gamma 1 isoform 4 [Homo sapiens] [gi:302699239]
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21
[SID4263567]
Absolute IC50 10.2388Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID855, Type: confirmatory]eukaryotic translation initiation factor 4E [Mus musculus] [gi:83627717]
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22
[SID4263567]
IC50 14.2Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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23
[SID26513892]
IC50 14.7MKP-3 in vitro secondary assay for identification of irreversible and slow-binding inhibitors [AID1052, Type: confirmatory]dual specificity protein phosphatase 6 [Rattus norvegicus] [gi:16758752]
View
24
[SID4263567]
Potency 15.8489qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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25
[SID4263567]
Potency 17.7828qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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26
[SID4263567]
Potency 19.0115qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
View
27
[SID4263567]
Potency 19.9526qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
View
28
[SID26513892]
IC50 27In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 2 [Homo sapiens] [gi:24234686]
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29
[SID26513892]
IC50 27In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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30
[SID4263567]
Potency 28.1838qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
View
31
[SID26513892]
IC50 95.4GAPDH Dose Response Colorimetric Assay [AID1227, Type: confirmatory]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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32
[SID4263567]
IC50 100A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
View
33
[SID4263567]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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34
[SID4263567]
384-well Z-Lyte format Hck-Nef inhibitor HTS: Confirmation Assays [AID463188, Type: other]
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35
[SID4263567]
qHTS Assay for Inhibitors of DNA Polymerase III Holoenzyme System [AID603, Type: confirmatory]
View
36
[SID4263567]
Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
View
37
[SID4263567]
MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment: Cdc25B Dose Response Selectivity Assay [AID676, Type: confirmatory]M-phase inducer phosphatase 2 isoform 2 [Homo sapiens] [gi:4757950]
View
38
[SID4263567]
In vitro Primary HTS Assay for MKP-1 [AID374, Type: screening]dual specificity protein phosphatase 1 [Homo sapiens] [gi:4758204]
View
39
[SID4263567]
In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay [AID551, Type: confirmatory]dual specificity protein phosphatase 1 [Homo sapiens] [gi:4758204]
View
40
[SID4263567]
In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of DTT [AID558, Type: confirmatory]dual specificity protein phosphatase 1 [Homo sapiens] [gi:4758204]
View
41
[SID4263567]
In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of Catalase [AID562, Type: confirmatory]dual specificity protein phosphatase 1 [Homo sapiens] [gi:4758204]
View
42
[SID4263567]
In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Reproducibility testing [AID563, Type: confirmatory]dual specificity protein phosphatase 1 [Homo sapiens] [gi:4758204]
View
43
[SID4263567]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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44
[SID4263567]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID2176, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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45
[SID4263567]
HIV-1 RT-RNase H MLSCN HTS MH077605 [AID565, Type: screening]Chain A, High Resolution Structures Of Hiv-1 Rt From Four Rt- Inhibitor Complexes [gi:1431733]
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46
[SID4263567]
Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
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47
[SID4263567]
uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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48
[SID4263567]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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49
[SID4263567]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO-conjugating enzyme UBC9 [Homo sapiens] [gi:4507785]
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50
[SID4263567]
IC50 uHTS HTRF assay for identification of inhibitors of SUMOylation [AID2006, Type: confirmatory]SUMO1 activating enzyme subunit 1 [Homo sapiens] [gi:17390638]
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