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Danazol (CID 28417) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(90)
 
 
Inactive(647)
 
 
Inconclusive(108)
 
 
Unspecified(1519)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
 
7TM GPCR Srsx(28)
 
 
 
 
NR LBD PPAR(21)
 
 
 
NR LBD AR(18)
 
 
 
 
NR LBD ER(18)
 
 
 
 
 
BioAssay Types:
Screening(364)
 
 
 
 
Confirmatory(278)
 
 
 
 
 
Literature(133)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(294)
 
 
 
 
 
IC50(153)
 
 
 
 
 
Kd(1)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2154    Data Row: 2364   Total Pages: 48   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103543149]
Kd 0.00631Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin [AID318680, Type: Literature]Sex hormone-binding globulin [gi:134907]
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2
[SID144212257]
Potency-Replicate_1 0.0097qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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3
[SID103543149]
IC50 0.012DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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4
[SID144212257]
Ratio Potency (uM) 0.0160903qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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5
[SID144212257]
Potency-Replicate_1 0.0347qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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6
[SID144205667]
Potency-Replicate_1 0.075qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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7
[SID144205667]
Ratio Potency (uM) 0.221476qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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8
[SID103543149]
IC50 0.259DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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9
[SID144205667]
Potency-Replicate_1 0.2683qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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10
[SID103543149]
IC50 0.3DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
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11
[SID144205667]
Potency-Replicate_1 0.6682qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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12
[SID144212257]
Potency-Replicate_1 0.9689qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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13
[SID144205667]
Ratio Potency (uM) 1.028qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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14
[SID103543149]
IC50 2.535DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: other]
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15
[SID103543149]
IC50 2.978DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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16
[SID26757819]
Potency 3.1623qHTS assay for small molecule agonists of estrogen receptor alpha signaling [AID588514, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID144205667]
Potency-Replicate_1 3.378qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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18
[SID103543149]
IC50 4.314DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) [AID625263, Type: other]Glucocorticoid receptor [gi:121069]
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19
[SID144205667]
Potency-Replicate_1 5.3538qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway [AID720692, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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20
[SID103543149]
IC50 5.698DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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21
[SID144205667]
Ratio Potency (uM) 5.77522qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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22
[SID144212257]
Potency-Replicate_1 6.166qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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23
[SID144212257]
Ratio Potency (uM) 6.65788qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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24
[SID103543149]
IC50 6.842DRUGMATRIX: Dopamine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625256, Type: other]Sodium-dependent dopamine transporter [gi:266667]
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25
[SID103543149]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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26
[SID103543149]
IC50 8.85DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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27
[SID144212257]
Potency-Replicate_1 9.6885qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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28
[SID103543149]
IC50 10Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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29
[SID103543149]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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30
[SID103543149]
IC50 11.16DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A3 [gi:1351831]
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31
[SID103543149]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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32
[SID103543149]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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33
[SID103543149]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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34
[SID103543149]
IC50 14.079DRUGMATRIX: Opiate mu (OP3, MOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625163, Type: other]Mu-type opioid receptor [gi:2851402]
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35
[SID144205667]
Potency 14.1254qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway [AID651751, Type: confirmatory]pregnane X receptor [Rattus norvegicus] [gi:5702233]
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36
[SID103543149]
IC50 14.61DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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37
[SID103543149]
IC50 14.649DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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38
[SID103543149]
IC50 15.42DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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39
[SID103543149]
IC50 15.518DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: other]Kappa-type opioid receptor [gi:116242691]
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40
[SID103543149]
IC50 17.02DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) [AID625206, Type: other]Beta-3 adrenergic receptor [gi:461604]
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41
[SID144212257]
Potency-Replicate_1 17.2289qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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42
[SID144212257]
Potency-Replicate_1 17.2289qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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43
[SID144212257]
Potency-Replicate_1 17.2289qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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44
[SID103543149]
IC50 17.747DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M3 [gi:113125]
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45
[SID103543149]
IC50 17.79DRUGMATRIX: Estrogen ERalpha radioligand binding (ligand: [3H] Estradiol) [AID625258, Type: other]Estrogen receptor [gi:544257]
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46
[SID103543149]
IC50 18.328DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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47
[SID103543149]
IC50 19.61DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
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48
[SID103543149]
IC50 20.449DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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49
[SID103543149]
IC50 23.163DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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50
[SID103543149]
IC50 23.752DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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