AK-968/12163546 (CID 2841620) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(61)
 
 
Inactive(405)
 
 
Inconclusive(20)
 
 
Unspecified(1)
 
 
Top Targets:
Bcl-2 like(16)
 
 
 
alkPPc(12)
 
 
7TM GPCR Srx(10)
 
 
7TM GPCR Srsx(7)
 
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(337)
 
 
 
 
 
Confirmatory(139)
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(74)
 
 
 
 
IC50(38)
 
 
 
 
EC50(22)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 487    Data Row: 487   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14736776]
Potency 2.3323Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
2
[SID14736776]
EC50 3.2Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. [AID1320, Type: confirmatory]bcl-2-related protein A1 isoform 1 [Homo sapiens] [gi:4757840]
View
3
[SID14736776]
EC50 3.2Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1. [AID1320, Type: confirmatory]bcl-2-related protein A1 isoform 1 [Homo sapiens] [gi:4757840]
View
4
[SID14736776]
Potency 3.9716qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
View
5
[SID14736776]
EC50 4.1Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
6
[SID14736776]
EC50 4.1Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
7
[SID14736776]
EC50 4.1Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
8
[SID14736776]
EC50 4.1Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
9
[SID14736776]
EC50 4.1Confirmation Dose Response screen for compounds that protect hERG from block by proarrhythmic agents [AID2121, Type: confirmatory]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
10
[SID14736776]
EC50 4.644Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A precursor [Streptococcus pyogenes M1 GAS] [gi:15675770]
View
11
[SID14736776]
EC50 6.536Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
View
12
[SID14736776]
EC50 6.905Luminescence Microorganism-Based Dose Response HTS to Identify Compounds Cytotoxic to Streptococcus [AID1915, Type: confirmatory]
View
13
[SID14736776]
IC50 7.037Dose response cell-based assay to measure STAT3 inhibition [AID1399, Type: confirmatory]STAT3 [Homo sapiens] [gi:13272532]
View
14
[SID14736776]
IC50 7.037Dose response cell-based assay to measure STAT3 inhibition [AID1399, Type: confirmatory]STAT3 [Homo sapiens] [gi:13272532]
View
15
[SID14736776]
IC50 7.037Dose response cell-based assay to measure STAT3 inhibition [AID1399, Type: confirmatory]STAT3 [Homo sapiens] [gi:13272532]
View
16
[SID14736776]
Potency 7.9433qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
View
17
[SID14736776]
Potency 8.9125qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
View
18
[SID14736776]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
View
19
[SID14736776]
Potency 10qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
View
20
[SID14736776]
Potency 10qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
View
21
[SID14736776]
Potency 10qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
View
22
[SID14736776]
Potency 11.2202qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
23
[SID14736776]
Potency 12.5893qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
View
24
[SID14736776]
Potency 12.5893qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
View
25
[SID14736776]
Potency 12.5893qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
View
26
[SID14736776]
Potency 13.4591qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
27
[SID14736776]
Potency 15.8489qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
28
[SID14736776]
Potency 15.8489qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
29
[SID14736776]
Potency 22.3872qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
View
30
[SID14736776]
Potency 35.4813qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
31
[SID14736776]
Potency 35.4813qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
View
32
[SID14736776]
 HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1497, Type: screening]integrin alpha-M isoform 2 precursor [Homo sapiens] [gi:88501734]
View
33
[SID14736776]
 HTS identification of compounds inhibiting the binding of CD11b/CD18 to fibrinogen via a luminescence assay. [AID1497, Type: screening]integrin alpha-M isoform 2 precursor [Homo sapiens] [gi:88501734]
View
34
[SID14736776]
 High throughput discovery of novel modulators of ROMK K+ channel activity: Retest of Primary Hits [AID1917, Type: other]Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi:223460826]
View
35
[SID14736776]
 High throughput discovery of novel modulators of ROMK K+ channel activity: Primary Screen [AID1918, Type: screening]Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi:223460826]
View
36
[SID14736776]
 Confirmatory screen for compounds that protect hERG from block by proarrhythmic agents [AID1835, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
37
[SID14736776]
 Confirmatory screen for compounds that protect hERG from block by proarrhythmic agents [AID1835, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
38
[SID14736776]
 Confirmatory screen for compounds that protect hERG from block by proarrhythmic agents [AID1835, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
39
[SID14736776]
 Confirmatory screen for compounds that protect hERG from block by proarrhythmic agents [AID1835, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
40
[SID14736776]
 Confirmatory screen for compounds that protect hERG from block by proarrhythmic agents [AID1835, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
41
[SID14736776]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
View
42
[SID14736776]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
View
43
[SID14736776]
 Confirmation cell-based high throughput screening assay to measure STAT3 inhibition [AID1265, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
44
[SID14736776]
 Confirmation cell-based high throughput screening assay to measure STAT3 inhibition [AID1265, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
45
[SID14736776]
 Confirmation cell-based high throughput screening assay to measure STAT3 inhibition [AID1265, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
46
[SID14736776]
 Primary cell-based high throughput screening assay to measure STAT3 inhibition [AID862, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
47
[SID14736776]
 Primary cell-based high throughput screening assay to measure STAT3 inhibition [AID862, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
48
[SID14736776]
 Primary cell-based high throughput screening assay to measure STAT3 inhibition [AID862, Type: screening]STAT3 [Homo sapiens] [gi:13272532]
View
49
[SID14736776]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
View
50
[SID14736776]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
View