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4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide (CID 2837695) - Compound BioActivity Data
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BioActivity Outcomes:
Active(35)
 
 
Inactive(694)
 
 
Inconclusive(38)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(20)
 
 
 
alkPPc(12)
 
 
 
Bcl-2 like(11)
 
 
Ras like GTPa..(11)
 
 
BioAssay Types:
Screening(476)
 
 
 
 
 
Confirmatory(247)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(152)
 
 
 
 
 
EC50(45)
 
 
 
IC50(40)
 
 
 
AC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 671    Data Row: 769   Total Pages: 39   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57578340]
EC50_MICROM 4.135SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 precursor [Homo sapiens] [gi:4757952]
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2
[SID57578340]
EC50_MICROM 6.141SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588373, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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3
[SID17432605]
Potency 8.1995A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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4
[SID17432605]
EC50_MICROM 8.225Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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5
[SID57578340]
EC50_MICROM 8.225Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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6
[SID17432605]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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7
[SID17432605]
WT IC50 12.101Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Confirmatory Screen [AID1361, Type: confirmatory]
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8
[SID17432605]
Potency 12.9953A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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9
[SID85148311]
EC50_MICROM 16.788Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2020, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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10
[SID17432605]
Potency 31.6228qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID2242, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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11
[SID17432605]
AC50_uM 66.641Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity [AID504773, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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12
[SID17432605]
AC50_uM 66.641Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity [AID504773, Type: confirmatory]Golgi-associated PDZ and coiled-coil motif-containing protein isoform b [Homo sapiens] [gi:62868213]
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13
[SID17432605]
Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-7 [AID463210, Type: screening]caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] [gi:55960760]
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14
[SID17432605]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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15
[SID57578340]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_2, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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16
[SID17432605]
uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphatase [AID2805, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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17
[SID17432605]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]fructose-bisphosphate aldolase [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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18
[SID17432605]
Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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19
[SID17432605]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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20
[SID17432605]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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