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4-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide (CID 2837695) - Compound BioActivity Data
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BioActivity Outcomes:
Active(35)
 
 
Inactive(687)
 
 
Inconclusive(38)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(20)
 
 
 
alkPPc(12)
 
 
 
Bcl-2 like(11)
 
 
Ras like GTPa..(11)
 
 
BioAssay Types:
Screening(475)
 
 
 
 
 
Confirmatory(247)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(152)
 
 
 
 
 
EC50(45)
 
 
 
IC50(40)
 
 
 
AC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 670    Data Row: 762   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57578340]
EC50_MICROM 4.135SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype, round 1 [AID588377, Type: confirmatory]cell division control protein 42 homolog isoform 1 precursor [Homo sapiens] [gi:4757952]
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2
[SID57578340]
EC50_MICROM 6.141SAR compounds for Cdc42 probe extension project tested by Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant, round 1 [AID588373, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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3
[SID17432605]
Potency 8.1995A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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4
[SID17432605]
EC50_MICROM 8.225Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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5
[SID57578340]
EC50_MICROM 8.225Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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6
[SID17432605]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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7
[SID17432605]
WT IC50 12.101Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Confirmatory Screen [AID1361, Type: confirmatory]
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8
[SID17432605]
Potency 12.9953A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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9
[SID85148311]
EC50_MICROM 16.788Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 activated mutant [AID2020, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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10
[SID17432605]
Potency 31.6228qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID2242, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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11
[SID17432605]
AC50_uM 66.641Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity [AID504773, Type: confirmatory]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
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12
[SID17432605]
AC50_uM 66.641Fluorescence Polarization with Cer CAL-PDZ Measured in Biochemical System Using Plate Reader - 2109-01_Inhibitor_Dose_CherryPick_Activity [AID504773, Type: confirmatory]Golgi-associated PDZ and coiled-coil motif-containing protein isoform b [Homo sapiens] [gi:62868213]
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13
[SID17432605]
HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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14
[SID57578340]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_2, Type: other]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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15
[SID17432605]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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16
[SID17432605]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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17
[SID17432605]
Counterscreen for procaspase-3 activators: absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-7 [AID463210, Type: screening]caspase 7, apoptosis-related cysteine peptidase [Homo sapiens] [gi:55960760]
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18
[SID17432605]
Absorbance-based primary biochemical high throughput screening assay to identify activators of procaspase-3 [AID463141, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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19
[SID17432605]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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20
[SID17432605]
Primary cell-based high-throughput screening assay to identify agonists of Galanin Receptor 2 (GALR2) [AID803, Type: screening]Galanin receptor type 2 [gi:6016094]
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21
[SID17432605]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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22
[SID17432605]
Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2227, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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23
[SID57578340]
Dose Response of round 1 SAR compounds for Cdc42 probe extension project tested by multiplex of eight GTPase proteins under the condition of Mg Buffer, non-chelator buffer [AID588477_3, Type: other]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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24
[SID17432605]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]troponin C, slow skeletal and cardiac muscles [Homo sapiens] [gi:4507615]
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25
[SID17432605]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin C, slow skeletal and cardiac muscles [Homo sapiens] [gi:4507615]
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26
[SID17432605]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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27
[SID85148311]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_3, Type: other]
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28
[SID85148311]
Dose Response of compounds for six proteins with constant GTP under the condition of Mg buffer [AID2393_4, Type: other]
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29
[SID17432605]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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30
[SID17432605]
Counterscreen for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF): Fluorescence-based biochemical assay to identify fluorescence artifacts [AID504382, Type: screening]
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31
[SID17432605]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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32
[SID17432605]
uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphatase [AID2805, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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33
[SID17432605]
Fluorescence-based biochemical high throughput confirmation assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504383, Type: screening]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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34
[SID17432605]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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35
[SID17432605]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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36
[SID17432605]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID17432605]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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38
[SID17432605]
Potency 0.0398qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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39
[SID17432605]
Potency 7.9433Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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40
[SID17432605]
Potency 12.5893qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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41
[SID17432605]
Potency 14.1254qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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42
[SID17432605]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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43
[SID144187792]
EC50_MICROM 20High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, compounds from Powder Set 02 [AID651880, Type: confirmatory]botulinum neurotoxin type F, BoNT/F [Clostridium botulinum Bf] [gi:168184763]
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44
[SID144187792]
EC50_MICROM 20High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, compounds from Powder Set 02 [AID651879, Type: confirmatory]botulinum neurotoxin type A [Clostridium botulinum A str. ATCC 3502] [gi:148378801]
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45
[SID144187792]
EC50_MICROM 20High-throughput multiplex microsphere dose response for inhibitors of toxin protease, specifically Lethal Factor protease, compounds from Powder Set 02 [AID651901, Type: confirmatory]lethal factor [Bacillus anthracis str. A2012] [gi:21392848]
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46
[SID17432605]
Potency 22.3872qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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47
[SID85148311]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID2045, Type: confirmatory]Ras-related protein Rab-2A [gi:46577642]
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48
[SID85148311]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype protein [AID2019, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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49
[SID85148311]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant [AID2050, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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50
[SID85148311]
EC50_MICROM 30Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID2047, Type: confirmatory]ras protein, partial [Homo sapiens] [gi:190938]
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