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2-(3-Dimethylamino-propyl)-benzo[de]isoquinoline-1,3-dione (CID 2834616) - Compound BioActivity Data
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BioActivity Outcomes:
Active(22)
 
 
Inactive(511)
 
 
Inconclusive(23)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(15)
 
 
CAP ED(5)
 
 
TRP 2(5)
 
 
ANK(4)
 
 
BioAssay Types:
Screening(368)
 
 
 
 
Confirmatory(171)
 
 
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
IC50(30)
 
 
 
AC50(9)
 
 
 
 
EC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 518    Data Row: 561   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49644305]
EC50 0.81496Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID463088, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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2
[SID49644305]
AbsAC26_uM 3.88Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_Dose_CherryPick_Activity [AID624491, Type: confirmatory]
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3
[SID49644305]
AC50_uM 5.4Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity [AID588849, Type: confirmatory]CAAX prenyl protease 2 isoform 2 [Homo sapiens] [gi:73858575]
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4
[SID49644305]
AC50_uM 11.08Identification of Inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_Dose_CherryPick_Activity [AID651657, Type: confirmatory]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
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5
[SID49644305]
AC50_uM 16.43FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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6
[SID49644305]
AC50_uM 37.96Trypsin Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-02_Inhibitor_Dose_CherryPick_Activity [AID488789, Type: confirmatory]Trypsin [gi:136429]
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7
[SID49644305]
Potency 67.4555qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds [AID720498, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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8
[SID49644305]
AC50_uM 68.1Ras-converting Enzyme/Cell Proliferation Pathway Measured in Biochemical System Using Plate Reader - 2034-01_Inhibitor_Dose_CherryPick [AID488788, Type: confirmatory]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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9
[SID49644305]
Fluorescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of the Ras-converting Enzyme [AID2563, Type: screening]Rce1p [Saccharomyces cerevisiae S288c] [gi:6323930]
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10
[SID49644305]
Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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11
[SID49644305]
Counter screen assay of the parental HEK293 cells for compounds that activate the Choline Transporter (CHT) [AID623908, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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12
[SID49644305]
Confirmatory screen for compounds that activate the Choline Transporter (CHT) [AID504833, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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13
[SID49644305]
Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberculosis [AID588726, Type: screening]Probable fructose-bisphosphate aldolase Fba [Mycobacterium tuberculosis H37Rv] [gi:15607504]
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14
[SID49644305]
Luciferase Reporter Cell Based HTS to identify inhibitors of N-linked Glycosylation Measured in Cell-Based System Using Plate Reader - 2146-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588692, Type: screening]
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15
[SID49644305]
Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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16
[SID49644305]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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17
[SID49644305]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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18
[SID49644305]
FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID651710, Type: screening]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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19
[SID49644305]
FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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20
[SID49644305]
Identification of inhibitors of RAD54 Measured in Biochemical System Using Plate Reader - 2159-01_Inhibitor_SinglePoint_HTS_Activity [AID602329, Type: screening]DNA repair and recombination protein RAD54-like [Homo sapiens] [gi:216548193]
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21
[SID49644305]
Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID1527, Type: screening]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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22
[SID49644305]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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23
[SID103226026]
IC50 100Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite-specific LDH release after 72 hrs by Malstat assay [AID478865, Type: Literature]
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24
[SID103226026]
IC50 100Cytotoxicity against mouse J774.1 cells after 48 hrs by alamar blue satining [AID478868, Type: Literature]
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25
[SID103226026]
Relative binding affinity for calf thymus DNA in MES 10 at 25 degrees C (Spectrophotometric data) [AID54461, Type: Literature]
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26
[SID103226026]
Thermal melting point of calf thymus DNA complexed with monoimide in MES 00 buffer (Spectrophotometric data) [AID54985, Type: Literature]
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27
[SID49644305]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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28
[SID49644305]
Potency 8.9125qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
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29
[SID49644305]
Potency 31.6228qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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30
[SID49644305]
EC50 42.903Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR) [AID463086, Type: confirmatory]nuclear receptor subfamily 1 group I member 2 isoform 1 [Homo sapiens] [gi:34398348]
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31
[SID49644305]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]PINK1 [Homo sapiens] [gi:37183032]
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32
[SID49644305]
uHTS identification of small molecule antagonists of the CCR6 receptor via a luminescent beta-arrestin assay [AID493098, Type: screening]C-C chemokine receptor type 6 [Homo sapiens] [gi:37187860]
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33
[SID49644305]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase 5 (PP5). [AID1987, Type: screening]PPP5C protein, partial [Homo sapiens] [gi:37589898]
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34
[SID49644305]
Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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35
[SID49644305]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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36
[SID49644305]
Fluorescence-based cell-based primary high throughput screening assay to identify positive allosteric modulators (PAMs) of the human M1 muscarinic receptor (CHRM1). [AID588819, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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37
[SID49644305]
uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COP9 signalosome complex subunit 5 [Homo sapiens] [gi:38027923]
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38
[SID49644305]
MLPCN SirT-5 Measured in Biochemical System Using Imaging - 7044-01_Inhibitor_SinglePoint_HTS_Activity_Set5 [AID652115, Type: screening]NAD-dependent protein deacylase sirtuin-5, mitochondrial [gi:38258652]
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39
[SID49644305]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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40
[SID49644305]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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41
[SID49644305]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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42
[SID49644305]
IC50 uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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43
[SID49644305]
uHTS identification of HIF-2a Inhibitors in a luminesence assay [AID624352, Type: screening]endothelial PAS domain-containing protein 1 [Homo sapiens] [gi:40254439]
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44
[SID49644305]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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45
[SID49644305]
IC50 uHTS identification of small molecule antagonists of the binding of Siah-1 and a peptide ligand via a fluorescence polarization assay. [AID1817, Type: confirmatory]plectin 1 [Homo sapiens] [gi:40849930]
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46
[SID49644305]
uHTS identification of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID602261, Type: screening]fatty acid synthase [Homo sapiens] [gi:41872631]
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47
[SID49644305]
Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 MEK Kinase3 Wildtype [AID1529, Type: screening]mitogen-activated protein kinase kinase kinase 3 isoform 1 [Homo sapiens] [gi:42794767]
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48
[SID49644305]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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49
[SID49644305]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]kelch-like ECH-associated protein 1 [Homo sapiens] [gi:45269145]
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50
[SID49644305]
IC50 uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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