GNF-Pf-4272 (CID 2832141) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(2)
 
 
Inactive(2)
 
 
Unspecified(3)
 
 
Top Targets:
RNase H(1)
 
 
BioAssay Types:
Screening(1)
 
 
Literature(1)
 
 
BioActivity Types:
EC50(2)
 
 
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 7   Total Pages: 1   
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103710594]
EC50 0.641NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: other]
View
2
[SID103710594]
EC50 0.742NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: other]
View
3
[SID103710594]
CC50 100NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) [AID449705, Type: other]
View
4
[SID103710594]
 NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. [AID449706, Type: other]
View
5
[SID103710594]
 NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. [AID602118, Type: other]
View
6
[SID131337143]
IC50 Novartis GNF Liver Stage Dataset: Malariabox Annotation [AID602156, Type: Literature]
View
7
[SID8062675]
 HIV-1 RNase H Inhibition [AID372, Type: screening]Chain A, Solution Structure Of The Rnase H Domain Of The Hiv-1 Reverse Transcriptase In The Presence [gi:28949057]
View