KRN 7000 (CID 2826713) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(57)
 
 
Top Targets:
IgC MHC I alp..(4)
 
 
BioAssay Types:
Literature(52)
 
 
BioActivity Types:
EC50(1)
 
 
Kd(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 57    Data Row: 57   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103505792]
Kd 0.35Binding affinity to T cell receptor [AID292516, Type: Literature]
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2
[SID103505792]
EC50 2.7Effect on immune response in human iNKT cells stimulated by antigen-presenting CD1d-transfected human HeLa cells assessed as induction of TNFalpha release by MTT assay [AID421559, Type: Literature]
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3
[SID103505792]
 Effect on immune response in human iNKT cells stimulated by antigen-presenting CD1d-transfected human HeLa cells assessed as induction of IFN-gamma realase by ELISA [AID421562, Type: Literature]
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4
[SID103505792]
 Effect on immune response in human iNKT cells stimulated by antigen-presenting CD1d-transfected human HeLa cells assessed as induction of IL4 release by ELISA [AID421563, Type: Literature]
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5
[SID103505792]
 Regulation of immune response in C57BL/6J mouse assessed as induction of NKT cell cytokine response-related IFN-gamma secretion at 10 to 1000 ug/kg, ip after 2 hrs by ELISA [AID421564, Type: Literature]
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6
[SID103505792]
 Induction of IFN-gamma production in mouse iNKT cells [AID340069, Type: Literature]
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7
[SID103505792]
 Induction of IL4/IL13 production in mouse iNKT cells [AID340070, Type: Literature]
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8
[SID103505792]
 Induction of IFN-gamma production in human iNKT cells [AID340072, Type: Literature]
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9
[SID103505792]
 Induction of IL4 production in human iNKT cells [AID340073, Type: Literature]
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10
[SID103505792]
 Induction of IL13 production in human iNKT cells [AID340074, Type: Literature]
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11
[SID103505792]
 Induction of IL4 production in C57BL/6 mouse natural killer T cells after 48 hrs by cytometric bead array [AID387826, Type: Literature]
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12
[SID103505792]
 Activation of dendritic cells in BALB/c mouse at 2 ug, iv after 72 hrs by flow cytometry [AID327275, Type: Literature]
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13
[SID103505792]
 Activation of B cells in BALB/c mouse at 2 ug, iv after 72 hrs by flow cytometry [AID327278, Type: Literature]
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14
[SID103505792]
 Increase in CD8/CD4 T cell ratio in BALB/c mouse at 2 ug, iv after 72 hrs by flow cytometry [AID327279, Type: Literature]
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15
[SID103505792]
 Antitumor activity in TC1 cells xenografted C57BL/6 mouse assessed as suppression of tumor growth at 2 ug, iv [AID327280, Type: Literature]
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16
[SID103505792]
 Antitumor activity in mouse 4T1 cells xenografted BALB/c mouse assessed as suppression of tumor growth at 2 ug, iv [AID327281, Type: Literature]
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17
[SID103505792]
 Induction of proliferation in mouse iNKT cells [AID340068, Type: Literature]
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18
[SID103505792]
 Binding affinity to C1R-hCD1d expressed in human B cells assessed as increase in Th1 cytokine release in mouse iNKT cells upto 100 ng/ml after 36 hrs by ELISA [AID551856, Type: Literature]Antigen-presenting glycoprotein CD1d [gi:115964]
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19
[SID103505792]
 Binding affinity to C1R-hCD1d expressed in human B cells assessed as activation of IFN-gamma release in human iNKT cells upto 100 ng/ml after 36 hrs by ELISA [AID551858, Type: Literature]Antigen-presenting glycoprotein CD1d [gi:115964]
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20
[SID103505792]
 Binding affinity to C1R-hCD1d expressed in human B cells assessed as activation of IL-4 release in human iNKT cells upto 100 ng/ml after 36 hrs by ELISA [AID551859, Type: Literature]Antigen-presenting glycoprotein CD1d [gi:115964]
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21
[SID103505792]
 Binding affinity to C1R-hCD1d expressed in human B cells assessed as increase in IFN-gamma/IL4 ratio in mouse iNKT cells upto 100 ng/ml after 36 hrs by ELISA [AID551861, Type: Literature]Antigen-presenting glycoprotein CD1d [gi:115964]
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22
[SID103505792]
 Elevation of IL4 in C57B/6 mouse at 1 ug, iv after 2 hrs [AID277790, Type: Literature]
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23
[SID103505792]
 Elevation of IFN-gamma in C57B/6 mouse at 1 ug, iv after 12 hrs [AID277791, Type: Literature]
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24
[SID103505792]
 Stimulation of hCD1d-restricted human iNKT cells assesed as IFN-gamma release at 10 ng/mL by ELISA [AID292514, Type: Literature]
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25
[SID103505792]
 Stimulation of hCD1d-restricted human iNKT cells assessed as IL4 release at 10 ng/mL by ELISA [AID292515, Type: Literature]
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26
[SID103505792]
 Stimulation of cell expansion of human invariant CD161+/ Valpha24+/ CD56+/ CD3+ NKT cells by flow cytometry method [AID327263, Type: Literature]
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27
[SID103505792]
 Immunostimulatory activity in mouse splenocytes assessed as IFNgamma production at 8 ng/ml after 72 hrs by ELISA [AID671518, Type: other]
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28
[SID103505792]
 Immunostimulatory activity in mouse splenocytes assessed as IL4 production at 8 ng/ml after 72 hrs by ELISA [AID671519, Type: other]
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29
[SID103505792]
 Immunomodulatory activity in mouse hepatic mononuclear cells containing iNKT cells assessed as IFNgamma release at 25 nM after 72 hrs by ELISA [AID671522, Type: other]
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30
[SID103505792]
 Immunomodulatory activity in mouse hepatic mononuclear cells containing iNKT cells assessed as IL4 release at 25 nM after 72 hrs by ELISA [AID671523, Type: other]
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31
[SID103505792]
 Immunostimulatory activity in C57BL/6J mouse assessed as increase in IL4 level at 2 ug, iv by cytometric bead array method [AID674456, Type: Literature]
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32
[SID103505792]
 Activation of Namalwa cell expressing CD1D-TCR in human MAD11 cells assessed as TH1-mediated TNFalpha secretion after 6 hrs relative to control [AID661317, Type: Literature]
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33
[SID103505792]
 Activation of Hela cell expressing human CD1D-TCR in human MAD11 cells assessed as TH1-mediated IFN-gamma secretion after 6 hrs by ELISA relative to KRN7000 [AID661318, Type: Literature]
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34
[SID103505792]
 Activation of Namalwa cell expressing CD1D-TCR in human MAD11 cells assessed as TH2-mediated IL-13 secretion after 48 hrs by ELISA relative to KRN7000 [AID661322, Type: Literature]
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35
[SID103505792]
 Activation of Hela cell expressing human CD1D-TCR in human MAD11 cells assessed as TH2-mediated IL-13 secretion after 48 hrs by ELISA relative to KRN7000 [AID661323, Type: Literature]
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36
[SID103505792]
 Activation of Namalwa cell expressing CD1D-TCR in human MAD11 cells assessed as TH1-mediated IFN-gamma secretion after 6 hrs by ELISA relative to KRN7000 [AID661324, Type: Literature]
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37
[SID103505792]
 Immunostimulatory activity in mouse DN32.D3 NKT hybridoma cells assessed as IL-2 production after 16 hrs by ELISA [AID671517, Type: other]
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38
[SID103505792]
 Antibacterial activity against luminescent Staphylococcus aureus Xen29 infected in BALB/c mouse deep thigh wound infection model assessed as reduction in bacterial load at 150 ug/kg, ip administered 3 hrs post infection by iVIS in-vivo imaging system [AID575778, Type: Literature]
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39
[SID103505792]
 Immunostimulatory activity in mouse DN3A4-1.2 cells expressing TCR assessed as IL2 level after 24 hrs by ELISA in presence of mouse CD1d protein [AID592908, Type: Literature]
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40
[SID103505792]
 Immunostimulatory activity in mouse N38.2H4 cells expressing TCR assessed as IL2 level after 24 by ELISA in presence of mouse CD1d protein [AID592997, Type: Literature]
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41
[SID103505792]
 Immunostimulatory activity in C57BL/6 mouse assessed as maximum IL4 level in serum at 10 ug/ml, iv after 2 hrs by ELISA [AID593004, Type: Literature]
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42
[SID103505792]
 Immunostimulatory activity in C57BL/6 mouse assessed as maximum INF-gamma level in serum at 10 ug/ml, iv after 2 hrs by ELISA [AID593005, Type: Literature]
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43
[SID103505792]
 Activation of Hela cell expressing human CD1D-TCR in human MAD11 cells assessed as TH1-mediated TNFalpha secretion after 6 hrs relative to control [AID661316, Type: Literature]
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44
[SID103505792]
 Activation of mouse DN32 cells in co-cultured with CD1d-transfected RAW cells assessed as IL-2 release after 16 hrs by ELISA [AID432521, Type: Literature]
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45
[SID103505792]
 Activation of mouse DN32 cells in co-cultured with plate bound antigen presenting cell free CD1d-FC fusion protein assessed as IL-2 release after 16 hrs by ELISA [AID432522, Type: Literature]
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46
[SID103505792]
 Activation of mouse DN32 cells co-cultured with CD1d-transfected RAW cells assessed as IL-2 release at 100 ng/ml pulsed for 3 hrs and then fixed measured after 16 hrs by ELISA [AID432523, Type: Literature]
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47
[SID103505792]
 Activation of mouse DN32 cells co-cultured with CD1d-transfected RAW cells assessed as IL-2 release at 100 ng/ml fixed and then pulsed for 3 hrs measured after 16 hrs by ELISA [AID432524, Type: Literature]
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48
[SID103505792]
 Induction of CD1D-mediated IL-13 production in human iNKT cells expressing CD4 at 400 nM after 18 hrs by ELISA [AID458489, Type: Literature]
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49
[SID103505792]
 Antibacterial activity against Sphingomonas capsulata ATCC 14666 infected in C57BL/6 mouse assessed as reduction in lung bacterial load at 100 ug/kg, ip administered 2 hrs post infection measured 24 hrs post infection [AID575776, Type: Literature]
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50
[SID103505792]
 Regulation of immune response in C57BL/6J mouse assessed as induction of NKT cell cytokine response-related IFN-gamma secretion at 10 to 1000 ug/kg, ip after 14 hrs by ELISA [AID421565, Type: Literature]
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