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MLS001181924 (CID 2818392) - Compound BioActivity Data
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BioActivity Outcomes:
Active(106)
 
 
Inactive(450)
 
 
Inconclusive(35)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(15)
 
 
 
KCNQ channel(8)
 
 
 
Troponin(6)
 
 
 
Peptidase S29(5)
 
 
 
BioAssay Types:
Screening(392)
 
 
 
 
Confirmatory(180)
 
 
 
 
 
Literature(12)
 
 
 
BioActivity Types:
Potency(129)
 
 
 
 
 
IC50(37)
 
 
 
 
EC50(9)
 
 
 
AC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 540    Data Row: 592   Total Pages: 30   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49679995]
EC50_uM 0.0609Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction [AID435023, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
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2
[SID49679995]
IC50 0.19009Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput counterscreen to identify inhibitors of TEM-1 metallo-beta-lactamase [AID2755, Type: confirmatory]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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3
[SID49679995]
IC50 0.37422Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID2754, Type: confirmatory]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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4
[SID49679995]
IC50 0.39877Epi-absorbance-based dose response assay for common IMP-1 and VIM-2 inhibitors: biochemical high throughput screening assay to identify inhibitors of IMP-1metallo-beta-lactamase [AID2756, Type: confirmatory]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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5
[SID49679995]
AbsAC35_uM 1.11Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Fischer Rat Thyroid (FRT) Cells. Measured in Cell-Based System Using Plate Reader - 7017-02_Other_Dose_CherryPick_Activity [AID743402, Type: confirmatory]
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6
[SID49679995]
AC50_uM 2.2Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_Dose_CherryPick_Activity [AID743267, Type: confirmatory]cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 [Homo sapiens] [gi:89348172]
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7
[SID49679995]
Potency 2.9935qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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8
[SID49679995]
Potency 3.5481Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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9
[SID49679995]
IC50 7.38Fluorescence-based biochemical high throughput dose response assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3). [AID2173, Type: confirmatory]NS3, partial [Hepatitis C virus] [gi:125541954]
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10
[SID49679995]
Potency 7.9433qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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11
[SID49679995]
Potency 8.9125qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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12
[SID49679995]
Potency 10.691qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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13
[SID49679995]
IC50 11.12uHTS identification of small molecule antagonists of the binding of Siah-1 and a peptide ligand via a fluorescence polarization assay. [AID1817, Type: confirmatory]plectin 1 [Homo sapiens] [gi:40849930]
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14
[SID49679995]
Potency 11.9955qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:72386991]
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15
[SID49679995]
Potency 14.1254qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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16
[SID49679995]
Potency 15.8489qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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17
[SID49679995]
AbsAC35_uM 17.81HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Other_Dose_CherryPick_Activity_Set2 [AID743395, Type: confirmatory]
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18
[SID49679995]
Potency 31.6228qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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19
[SID49679995]
Potency 31.6228qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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20
[SID49679995]
Potency 33.5875qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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