Clomipramine (CID 2801) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(90)
 
 
Inactive(330)
 
 
Inconclusive(124)
 
 
Unspecified(1586)
 
 
Top Targets:
p450(40)
 
 
 
 
 
7TM GPCR Srx(17)
 
 
 
 
7TM GPCR Srsx(11)
 
 
 
 
Pyr redox dim(8)
 
 
 
 
PLN02808(8)
 
 
BioAssay Types:
Confirmatory(334)
 
 
 
 
 
Literature(219)
 
 
 
 
 
Screening(24)
 
 
 
BioActivity Types:
Potency(267)
 
 
 
 
 
IC50(152)
 
 
 
 
 
Ki(11)
 
 
 
EC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1868    Data Row: 2130   Total Pages: 43   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164619]
IC50 4e-05Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptor [AID36031, Type: Literature]
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2
[SID103164619]
IC50 8.8e-05DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103164619]
IC50 8.8e-05DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103164619]
IC50 8.8e-05DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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5
[SID103164619]
IC50 0.0002Compound tested for its inhibitory activity against Histamine H1 receptor [AID87513, Type: Literature]
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6
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: other]5-hydroxytryptamine receptor 2A [gi:112808]
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7
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: other]5-hydroxytryptamine receptor 2A [gi:112808]
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8
[SID103164619]
Ki 0.0083Binding affinity towards 5-hydroxytryptamine 2 receptor [AID5241, Type: Literature]
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9
[SID103164619]
IC50 0.02Inhibition of uptake of 5-HT in rat brain cortex [AID181682, Type: Literature]
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10
[SID103164619]
IC50 0.034DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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11
[SID103164619]
IC50 0.034DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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12
[SID103164619]
IC50 0.034DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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13
[SID103164619]
Ki 0.043Compound was tested for its binding affinity towards brain (neocortex) Adenylate cyclase [AID34293, Type: Literature]
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14
[SID103164619]
IC50 0.046Compound was tested for its inhibitory activity against Noradrenaline receptor [AID147591, Type: Literature]
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15
[SID103164619]
Ki 0.051Binding affinity towards alpha-2 adrenergic receptor [AID218807, Type: Literature]
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16
[SID103164619]
IC50 0.053DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M [gi:543761]
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17
[SID103164619]
IC50 0.053DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M [gi:543761]
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18
[SID103164619]
IC50 0.053DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M [gi:543761]
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19
[SID103164619]
IC50 0.053DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M [gi:543761]
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20
[SID103164619]
Ki 0.055Compound was tested for its binding affinity towards brain (Hippocampus) Adenylate cyclase [AID34292, Type: Literature]
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21
[SID103164619]
Ki 0.056Binding affinity towards Dopamine receptor D2 [AID65239, Type: Literature]
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22
[SID103164619]
IC50 0.067DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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23
[SID103164619]
IC50 0.067DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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24
[SID103164619]
IC50 0.067DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
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25
[SID103164619]
IC50 0.07In vivo inhibition of uptake of 5-HT in human platelets [AID92822, Type: Literature]
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26
[SID103164619]
IC50 0.071DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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27
[SID103164619]
IC50 0.071DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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28
[SID103164619]
Ki 0.075Binding affinity towards alpha-1 adrenergic receptor [AID218673, Type: Literature]
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29
[SID103164619]
IC50 0.085DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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30
[SID103164619]
IC50 0.085DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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31
[SID103164619]
IC50 0.09In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slices [AID132666, Type: Literature]
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32
[SID103164619]
IC50 0.091DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625151, Type: other]Muscarinic acetylcholine receptor M [gi:113118]
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33
[SID103164619]
IC50 0.091DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625151, Type: other]Muscarinic acetylcholine receptor M [gi:113118]
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34
[SID103164619]
IC50 0.091DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M [gi:23503039]
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35
[SID103164619]
IC50 0.091DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M [gi:23503039]
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36
[SID103164619]
IC50 0.091DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M [gi:23503039]
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37
[SID103164619]
IC50 0.099DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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38
[SID11110978]
Potency 0.1qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response [AID943, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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39
[SID11110978]
Potency 0.1qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response [AID943, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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40
[SID11110978]
Potency 0.1qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response [AID943, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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41
[SID103164619]
IC50 0.101DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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42
[SID103164619]
IC50 0.101DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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43
[SID103164619]
IC50 0.132DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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44
[SID103164619]
IC50 0.132DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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45
[SID103164619]
IC50 0.139DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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46
[SID103164619]
IC50 0.139DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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47
[SID103164619]
IC50 0.139DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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48
[SID103164619]
IC50 0.139DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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49
[SID103164619]
IC50 0.17DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M [gi:113125]
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50
[SID103164619]
IC50 0.17DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M [gi:113125]
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