Bookmark and Share
Clomipramine (CID 2801) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(119)
 
 
Inactive(399)
 
 
Inconclusive(165)
 
 
Unspecified(1589)
 
 
Top Targets:
p450(39)
 
 
 
 
 
7TM GPCR Srx(27)
 
 
 
 
7TM GPCR Srsx(22)
 
 
 
 
HSD10-like SD..(12)
 
 
NR LBD GR(11)
 
 
 
 
BioAssay Types:
Confirmatory(435)
 
 
 
 
 
Literature(234)
 
 
 
 
 
Screening(24)
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(383)
 
 
 
 
 
IC50(165)
 
 
 
 
 
Ki(12)
 
 
 
EC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1971    Data Row: 2272   Total Pages: 46   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164619]
IC50 4e-05Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptor [AID36031, Type: Literature]
View
2
[SID103164619]
IC50 8.8e-05DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
View
3
[SID103164619]
IC50 0.0002Compound tested for its inhibitory activity against Histamine H1 receptor [AID87513, Type: Literature]
View
4
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 1F [gi:398968]
View
5
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 2B [gi:398970]
View
6
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 7 [gi:461440]
View
7
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 5A [gi:543729]
View
8
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 5B [gi:543730]
View
9
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1168221]
View
10
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 3A [gi:1168223]
View
11
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 2A [gi:112808]
View
12
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 1A [gi:112812]
View
13
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 1B [gi:112815]
View
14
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 2C [gi:112817]
View
15
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 1D [gi:112820]
View
16
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 4 [gi:2494928]
View
17
[SID103164619]
IC50 0.005Compound was tested for its inhibitory activity against 5-hydroxytryptamine receptor [AID6418, Type: Literature]5-hydroxytryptamine receptor 3B [gi:81868595]
View
18
[SID103164619]
Ki 0.0083Binding affinity towards 5-hydroxytryptamine 2 receptor [AID5241, Type: Literature]
View
19
[SID103164619]
IC50 0.02Inhibition of uptake of 5-HT in rat brain cortex [AID181682, Type: Literature]
View
20
[SID103164619]
IC50 0.034DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
View
21
[SID103164619]
Ki 0.043Compound was tested for its binding affinity towards brain (neocortex) Adenylate cyclase [AID34293, Type: Literature]
View
22
[SID103164619]
IC50 0.046Compound was tested for its inhibitory activity against Noradrenaline receptor [AID147591, Type: Literature]
View
23
[SID103164619]
Ki 0.051Binding affinity towards alpha-2 adrenergic receptor [AID218807, Type: Literature]
View
24
[SID103164619]
IC50 0.053DRUGMATRIX: Muscarinic M5 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625155, Type: other]Muscarinic acetylcholine receptor M5 [gi:543761]
View
25
[SID103164619]
Ki 0.055Compound was tested for its binding affinity towards brain (Hippocampus) Adenylate cyclase [AID34292, Type: Literature]
View
26
[SID103164619]
Ki 0.056Binding affinity towards Dopamine receptor D2 [AID65239, Type: Literature]
View
27
[SID103164619]
IC50 0.067DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2A radioligand binding (ligand: [3H] Ketanserin) [AID625192, Type: other]5-hydroxytryptamine receptor 2A [gi:543727]
View
28
[SID103164619]
IC50 0.07In vivo inhibition of uptake of 5-HT in human platelets [AID92822, Type: Literature]
View
29
[SID103164619]
IC50 0.071DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
View
30
[SID103164619]
Ki 0.075Binding affinity towards alpha-1 adrenergic receptor [AID218673, Type: Literature]
View
31
[SID103164619]
IC50 0.085DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
View
32
[SID103164619]
IC50 0.09In vitro inhibition of accumulation of [14C]5-HT (5-HT) in mouse brain slices [AID132666, Type: Literature]
View
33
[SID103164619]
IC50 0.091DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625151, Type: other]Muscarinic acetylcholine receptor M1 [gi:113118]
View
34
[SID103164619]
IC50 0.091DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M4 [gi:23503039]
View
35
[SID103164619]
IC50 0.099DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
View
36
[SID11110978]
Potency 0.1qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Kinetic Measurement of Intracellular Calcium Response [AID943, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
View
37
[SID103164619]
IC50 0.101DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
View
38
[SID103164619]
Ki 0.112Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting [AID691260, Type: Literature]5-hydroxytryptamine receptor 6 [gi:1703010]
View
39
[SID103164619]
IC50 0.132DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
View
40
[SID103164619]
IC50 0.139DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
View
41
[SID103164619]
IC50 0.17DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M3 [gi:113125]
View
42
[SID103164619]
IC50 0.18DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
View
43
[SID103164619]
IC50 0.239DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
View
44
[SID103164619]
IC50 0.241DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625152, Type: other]Muscarinic acetylcholine receptor M2 [gi:113122]
View
45
[SID103164619]
IC50 0.245DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625221, Type: other]5-hydroxytryptamine receptor 6 [gi:1703010]
View
46
[SID103164619]
IC50 0.413DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
View
47
[SID103164619]
Km 0.42Activity at Aquifex aeolicus sodium-coupled leucine transporter assessed as inhibition of L-[3H]Ala transport at 1 uM [AID329206, Type: Literature]
View
48
[SID103164619]
Km 0.47Activity at Aquifex aeolicus sodium-coupled leucine transporter assessed as inhibition of L-[3H]Ala transport at 20 uM [AID329207, Type: Literature]
View
49
[SID103164619]
Km 0.48Activity at Aquifex aeolicus sodium-coupled leucine transporter assessed as inhibition of L-[3H]Ala transport at 50 uM [AID329208, Type: Literature]
View
50
[SID103164619]
IC50 0.506DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
View