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Citalopram (CID 2771) - Compound BioActivity Data
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Filters: All Data » Active      
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BioActivity Outcomes:
Active(51)
 
 
Top Targets:
SLC6sbd SERT(12)
 
 
CAP ED(4)
 
 
7TM GPCR Srsx(2)
 
 
7TM GPCR Srx(1)
 
 
ERG2 Sigma1R(1)
 
 
BioAssay Types:
Literature(33)
 
 
Confirmatory(14)
 
 
Screening(2)
 
 
BioActivity Types:
IC50(25)
 
 
Ki(16)
 
 
EC50(2)
 
 
Potency(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 51    Data Row: 51   Total Pages: 3   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177051]
IC50 0.000902DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: confirmatory]Sodium-dependent serotonin transporter [gi:400630]
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2
[SID103177051]
Ki 0.0015Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortex [AID204703, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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3
[SID103177051]
Ki 0.0016Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortex [AID239125, Type: Literature]
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4
[SID103177051]
Ki 0.0016Inhibition of [125I]RTI-55 binding to human serotonin transporter expressed in human embryonic kidney cells [AID204199, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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5
[SID103177051]
IC50 0.0018Inhibition of 5-HT uptake in rat synaptosomal fraction [AID179069, Type: Literature]
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6
[SID103177051]
Ki 0.00194Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting [AID499947, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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7
[SID103177051]
Ki 0.0029Tested in vitro for serotonin(5-HT) neuronal uptake inhibition [AID134217, Type: Literature]
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8
[SID103177051]
IC50 0.00317Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation counting [AID471630, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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9
[SID103177051]
IC50 0.0039Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation counting [AID712520, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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10
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID361595, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID408801, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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12
[SID103177051]
Ki 0.016Inhibition of [3H]5-HT uptake at human SERT expressed in COS7 cells after 3 mins by beta-counting [AID731395, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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13
[SID103177051]
IC50 0.019Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay [AID576813, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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14
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID408802, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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15
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID361596, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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16
[SID103177051]
IC50 0.297DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: confirmatory]5-hydroxytryptamine receptor 2C [gi:112816]
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17
[SID103177051]
IC50 0.398DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: confirmatory]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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18
[SID103177051]
IC50 1.025DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: confirmatory]
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19
[SID103177051]
IC50 1.756DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: confirmatory]Alpha-1D adrenergic receptor [gi:1168244]
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20
[SID103177051]
IC50 1.786DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: confirmatory]
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