Citalopram (CID 2771) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(46)
 
 
Inactive(430)
 
 
Inconclusive(19)
 
 
Unspecified(220)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
 
7TM GPCR Srsx(16)
 
 
 
 
SLC6sbd SERT(13)
 
 
 
Tryp SPc(13)
 
 
 
Bcl-2 like(10)
 
 
BioAssay Types:
Screening(233)
 
 
 
 
Confirmatory(185)
 
 
 
 
Literature(138)
 
 
 
 
 
BioActivity Types:
IC50(158)
 
 
 
 
Potency(134)
 
 
 
 
Ki(17)
 
 
 
EC50(10)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 701    Data Row: 715   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177051]
IC50 0.000902DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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2
[SID103177051]
IC50 0.000902DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103177051]
IC50 0.000902DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103177051]
Ki 0.0015Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortex [AID204703, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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5
[SID103177051]
Ki 0.0016Inhibition of [125I]RTI-55 binding to human serotonin transporter expressed in human embryonic kidney cells [AID204199, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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6
[SID103177051]
Ki 0.0016Inhibition of [125I]RTI-55 binding to human serotonin transporter expressed in human embryonic kidney cells [AID204199, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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7
[SID103177051]
Ki 0.0016Inhibition of [125I]RTI-55 binding to human serotonin transporter expressed in human embryonic kidney cells [AID204199, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID103177051]
Ki 0.0016Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortex [AID239125, Type: Literature]
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9
[SID103177051]
IC50 0.0018Inhibition of 5-HT uptake in rat synaptosomal fraction [AID179069, Type: Literature]
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10
[SID103177051]
Ki 0.00194Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting [AID499947, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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11
[SID103177051]
Ki 0.0029Tested in vitro for serotonin(5-HT) neuronal uptake inhibition [AID134217, Type: Literature]
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12
[SID103177051]
IC50 0.00317Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation counting [AID471630, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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13
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID361595, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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14
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID361595, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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15
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID361595, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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16
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID408801, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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17
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID408801, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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18
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID408801, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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19
[SID103177051]
IC50 0.019Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay [AID576813, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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20
[SID103177051]
IC50 0.019Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay [AID576813, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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21
[SID103177051]
IC50 0.019Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay [AID576813, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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22
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID408802, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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23
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID408802, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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24
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID408802, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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25
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID361596, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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26
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID361596, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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27
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID361596, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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28
[SID103177051]
IC50 0.297DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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29
[SID103177051]
IC50 0.297DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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30
[SID103177051]
IC50 0.297DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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31
[SID103177051]
IC50 0.398DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: other]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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32
[SID103177051]
IC50 0.398DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: other]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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33
[SID103177051]
IC50 1.025DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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34
[SID103177051]
IC50 1.756DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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35
[SID103177051]
IC50 1.786DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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36
[SID103177051]
IC50 1.839DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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37
[SID103177051]
IC50 1.839DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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38
[SID103177051]
IC50 1.839DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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39
[SID103177051]
IC50 2.196DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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40
[SID103177051]
IC50 2.196DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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41
[SID103177051]
IC50 2.641DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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42
[SID103177051]
IC50 3.194DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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43
[SID103177051]
IC50 3.194DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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44
[SID103177051]
IC50 3.288DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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45
[SID103177051]
IC50 3.288DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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46
[SID103177051]
IC50 3.289DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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47
[SID103177051]
IC50 3.289DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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48
[SID103177051]
IC50 3.289DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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49
[SID103177051]
IC50 3.98107Inhibitory concentration against potassium channel HERG [AID243151, Type: Literature]
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50
[SID103177051]
IC50 3.98107Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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