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Citalopram (CID 2771) - Compound BioActivity Data
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BioActivity Outcomes:
Active(51)
 
 
Inactive(478)
 
 
Inconclusive(22)
 
 
Unspecified(228)
 
 
Top Targets:
7TM GPCR Srx(33)
 
 
 
 
 
7TM GPCR Srsx(26)
 
 
 
 
SLC6sbd SERT(16)
 
 
 
Tryp SPc(14)
 
 
 
Bcl-2 like(10)
 
 
BioAssay Types:
Screening(246)
 
 
 
 
Confirmatory(212)
 
 
 
 
Literature(154)
 
 
 
 
 
BioActivity Types:
IC50(165)
 
 
 
 
Potency(153)
 
 
 
 
Ki(22)
 
 
 
 
EC50(13)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 729    Data Row: 779   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177051]
IC50 0.000902DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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2
[SID103177051]
Ki 0.0015Inhibition of [3H]citalopram binding to Serotonin transporter of rat cerebral cortex [AID204703, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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3
[SID103177051]
Ki 0.0016Inhibition of [125I]RTI-55 binding to human serotonin transporter expressed in human embryonic kidney cells [AID204199, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103177051]
Ki 0.0016Displacement of [3H]paroxetine from serotonin transporter of rat cerebral cortex [AID239125, Type: Literature]
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5
[SID103177051]
IC50 0.0018Inhibition of 5-HT uptake in rat synaptosomal fraction [AID179069, Type: Literature]
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6
[SID103177051]
Ki 0.00194Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting [AID499947, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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7
[SID103177051]
Ki 0.0029Tested in vitro for serotonin(5-HT) neuronal uptake inhibition [AID134217, Type: Literature]
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8
[SID103177051]
IC50 0.00317Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation counting [AID471630, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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9
[SID103177051]
IC50 0.0039Inhibition of SERT-mediated [3H]5HT uptake in rat synaptosomes by scintillation counting [AID712520, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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10
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID361595, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103177051]
Ki 0.00438Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID408801, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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12
[SID103177051]
Ki 0.016Inhibition of [3H]5-HT uptake at human SERT expressed in COS7 cells after 3 mins by beta-counting [AID731395, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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13
[SID103177051]
IC50 0.019Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay [AID576813, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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14
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID408802, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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15
[SID103177051]
Ki 0.0328Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID361596, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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16
[SID103177051]
IC50 0.297DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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17
[SID103177051]
IC50 0.398DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: other]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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18
[SID103177051]
IC50 1.025DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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19
[SID103177051]
IC50 1.756DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625198, Type: other]Alpha-1D adrenergic receptor [gi:1168244]
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20
[SID103177051]
IC50 1.786DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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21
[SID103177051]
IC50 1.839DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) [AID625217, Type: other]5-hydroxytryptamine receptor 2B [gi:1168220]
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22
[SID103177051]
IC50 2.196DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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23
[SID103177051]
IC50 2.641DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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24
[SID103177051]
IC50 3.194DRUGMATRIX: Histamine H1, Central radioligand binding (ligand: [3H] Pyrilamine) [AID625269, Type: other]Histamine H1 receptor [gi:547645]
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25
[SID103177051]
IC50 3.288DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) [AID625199, Type: other]Alpha-1B adrenergic receptor [gi:543734]
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26
[SID103177051]
IC50 3.289DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) [AID625200, Type: other]Alpha-1D adrenergic receptor [gi:1168243]
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27
[SID103177051]
IC50 3.98107Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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28
[SID103177051]
IC50 3.98107Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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29
[SID103177051]
IC50 3.98107Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique [AID408340, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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30
[SID103177051]
IC50 3.98107Inhibitory concentration against potassium channel HERG [AID243151, Type: Literature]
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31
[SID103177051]
Ki 5.95Displacement of [3H]nisoxetine from NET in rat frontal cortex by scintillation counting [AID499948, Type: Literature]Norepinephrine transporter [gi:81890335]
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32
[SID103177051]
Ki 6.19In vitro binding affinity against human norepinephrine transporter in human embryonic kidney cell line by using [3H]-nisoxatine radioligand [AID147725, Type: Literature]
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33
[SID103177051]
Ki 6.19Displacement of [3H]nisoxetine from norepinephrine transporter of rat cerebral cortex [AID239218, Type: Literature]
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34
[SID103177051]
IC50 8.8Inhibition of noradrenaline uptake in rat synaptosomal fraction [AID179081, Type: Literature]
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35
[SID103177051]
Ki 9.27Displacement of [3H]WIN-35428 from DAT in rat caudate-putamen by scintillation counting [AID499949, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
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36
[SID103177051]
EC50 15.8489Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 48 hrs neutral red dye assay [AID576811, Type: Literature]
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37
[SID103177051]
Ki 16.54Displacement of [3H]GBR-12935 from dopamine transporter of rat caudate-putamen [AID239085, Type: Literature]
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38
[SID103177051]
Ki 16.54In vitro binding affinity against human dopamine transporter in dog kidney cell line by using [125I]RTI-55 radioligand [AID64517, Type: Literature]
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39
[SID103177051]
IC50 16.6754DRUGMATRIX: Potassium Channel HERG radioligand binding (ligand: [3H] Astemizole) [AID625171, Type: other]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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40
[SID103177051]
IC50 18.8Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy [AID386625, Type: Literature]Solute carrier family 22 member 1 [gi:313104181]
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41
[SID103177051]
EC50 25.1189Cytotoxicity against human SH-SY5Y cells expressing human SERT assessed as decrease in cell viability after 48 hrs neutral red dye assay [AID576803, Type: Literature]
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42
[SID103177051]
IC50 41Inhibition of dopamine uptake in rat synaptosomal fraction [AID179076, Type: Literature]
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43
[SID855965]
Potency 70.7946qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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44
[SID48415786]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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45
[SID85209895]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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46
[SID103177051]
IC50 Cytotoxicity against human chemoresistant DG75 cells expressing SERT assessed as decrease in cell viability 10 or 50 uM after 72 hrs Alamar blue assay [AID576805, Type: Literature]
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47
[SID103177051]
Phospholipidosis-positive literature compound observed in rat [AID540237, Type: Literature]
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48
[SID103177051]
Potentiation of 5-hydroxytryptophan-induced stereotypic behavior in mouse at 10 mg/kg, po administered 2 hrs before 5-hydroxytryptophan challenge measured for 30 mins [AID491771, Type: Literature]
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49
[SID103177051]
Potentiation of 5-hydroxytryptophan-induced stereotpic behavior in CD1 mouse at 10 mg/kg, po administered 120 mins before 5HTP challenge measured for 30 mins [AID462725, Type: Literature]
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50
[SID855965]
Discovery of Novel Allosteric Modulators of the M1 Muscarinic Receptor: Agonist Primary Screen [AID626, Type: screening]
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