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ciglitazone (CID 2750) - Compound BioActivity Data
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BioActivity Outcomes:
Active(56)
 
 
Inactive(259)
 
 
Inconclusive(70)
 
 
Unspecified(181)
 
 
Top Targets:
NR LBD PPAR(23)
 
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
 
7TM GPCR Srx(17)
 
 
 
NR LBD TR(13)
 
 
 
 
NR LBD ER(11)
 
 
 
 
BioAssay Types:
Confirmatory(229)
 
 
 
 
Literature(150)
 
 
 
 
 
Summary(24)
 
 
 
 
Screening(15)
 
 
BioActivity Types:
Potency(237)
 
 
 
 
IC50(120)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 420    Data Row: 566   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165086]
IC50 0.086DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) [AID625236, Type: other]Carbonic anhydrase 2 [gi:115456]
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2
[SID103165086]
IC50 0.225Inhibition of human recombinant MAO-B after 15 mins [AID501302, Type: Literature]Amine oxidase [flavin-containing] B [gi:113980]
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3
[SID144205673]
Ratio Potency (uM) 2.05113qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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4
[SID103165086]
IC50 2.22DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: other]Sodium-dependent noradrenaline transporter [gi:128616]
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5
[SID103165086]
EC50 3In vitro transcriptional activation of Peroxisome proliferator activated receptor gamma (PPAR) expressed in CV-1 cells [AID157283, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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6
[SID103165086]
IC50 3.047DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: other]Adenosine receptor A3 [gi:1351831]
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7
[SID103165086]
IC50 4.655DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: other]Epidermal growth factor receptor [gi:2811086]
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8
[SID144205673]
Potency-Replicate_1 6.6824qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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9
[SID144205673]
Ratio Potency (uM) 8.21714qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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10
[SID144205673]
Potency 8.4144qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID144205673]
Potency-Replicate_1 10.5909qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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12
[SID170466553]
Potency-Replicate_1 10.6822qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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13
[SID144205673]
Potency-Replicate_1 11.8832qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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14
[SID144205673]
Potency-Replicate_1 11.8832qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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15
[SID103165086]
IC50 12.576DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: other]Substance-K receptor [gi:229462950]
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16
[SID103165086]
IC50 13.258DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: other]Alpha-2B adrenergic receptor [gi:27151763]
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17
[SID26752161]
Potency 14.1254Confirmation Assay for Identification of Novel General Anesthetics [AID489008, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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18
[SID103165086]
EC50 14.9Agonist activity at human PPARgamma expressed in mouse NIH/3T3 cells assessed as receptor activation after 16 hrs by luciferase based reporter gene assay [AID358948, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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19
[SID103165086]
IC50 14.947DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M3 [gi:113125]
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20
[SID103165086]
IC50 14.948DRUGMATRIX: Transporter, Serotonin (5-Hydroxytryptamine) (SERT) radioligand binding (ligand: [3H] Paroxetine) [AID625222, Type: other]Sodium-dependent serotonin transporter [gi:400630]
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21
[SID103165086]
IC50 15.026DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) [AID625193, Type: other]Acetylcholinesterase [gi:113037]
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22
[SID26757865]
Potency 16.1366Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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23
[SID103165086]
IC50 16.224DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M4 [gi:23503039]
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24
[SID103165086]
IC50 16.551DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) [AID625201, Type: other]Alpha-2A adrenergic receptor [gi:1351829]
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25
[SID103165086]
IC50 17.871DRUGMATRIX: Adrenergic beta3 radioligand binding (ligand: [125I] Cyanopindolol) [AID625206, Type: other]Beta-3 adrenergic receptor [gi:461604]
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26
[SID103165086]
IC50 19.785DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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27
[SID26757865]
Potency 19.9526Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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28
[SID103165086]
IC50 20Concentration required for 50% inhibition of cell proliferation in PC12 cells using sulforhodamine B assay [AID155860, Type: Literature]
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29
[SID103165086]
IC50 21.107DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625152, Type: other]Muscarinic acetylcholine receptor M2 [gi:113122]
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30
[SID144205673]
Potency-Replicate_1 23.7101qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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31
[SID144205673]
Potency-Replicate_1 23.7101qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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32
[SID144205673]
Potency-Replicate_1 23.9145qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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33
[SID26757865]
Potency 25.1189qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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34
[SID144205673]
Potency-Replicate_1 26.6032qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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35
[SID103165086]
IC50 26.704DRUGMATRIX: Dopamine D3 radioligand binding (ligand: [3H] Spiperone) [AID625254, Type: other]D(3) dopamine receptor [gi:1169206]
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36
[SID103165086]
IC50 26.894DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: other]Delta-type opioid receptor [gi:311033488]
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37
[SID103165086]
IC50 28.621DRUGMATRIX: Melanocortin MC5 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625149, Type: other]Melanocortin receptor 5 [gi:729996]
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38
[SID103165086]
IC50 29.118DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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39
[SID103165086]
IC50 29.193DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) [AID625150, Type: other]Amine oxidase [flavin-containing] A [gi:113978]
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40
[SID170466553]
Ratio Potency (uM) 29.847qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743239, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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41
[SID170466553]
Potency-Replicate_1 29.847qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743220, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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42
[SID26752161]
Potency 31.6228qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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43
[SID144205673]
Potency-Replicate_1 33.4915qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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44
[SID144205673]
Potency-Replicate_1 44.6684qHTS assay for small molecule activators of the human pregnane X receptor (PXR) signaling pathway [AID720659, Type: confirmatory]pregnane X nuclear receptor [Homo sapiens] [gi:325495557]
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45
[SID144205673]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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46
[SID103165086]
Reduction of Stat3 phosphorylation in LPS-treated human THP1 macrophages at 10 uM relative to control [AID462679, Type: Literature]Signal transducer and activator of transcription 3 [gi:48429227]
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47
[SID103165086]
Activation of GAL4 fused human PPARgamma ligand binding domain transfected in african green monkey CV1 cells at 10 uM by CAT reporter assay [AID381057, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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48
[SID103165086]
Activity at PPARgamma in LPS-treated human THP1 cells co-transfected with PPRE-x3-TK-luc assessed as luciferase activity at 10 uM [AID462674, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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49
[SID103165086]
Transactivation of mouse recombinant PPARgamma expressed in mouse NIH3T3 cells by PPRE activation based dual luciferase reporter gene assay relative to control [AID416167, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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50
[SID103165086]
Tested for the intracellular Ca+2 release in PC12 cells; + = Release [AID155853, Type: Literature]
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