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ciglitazone (CID 2750) - Compound BioActivity Data
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BioActivity Outcomes:
Active(60)
 
 
Inactive(264)
 
 
Inconclusive(67)
 
 
Unspecified(182)
 
 
Top Targets:
7tm 4(33)
 
 
 
 
NR LBD PPAR(28)
 
 
 
 
 
NR LBD TR(13)
 
 
 
 
NR LBD ER(11)
 
 
 
 
NR LBD VDR(10)
 
 
 
BioAssay Types:
Confirmatory(347)
 
 
 
 
 
Literature(156)
 
 
 
 
 
Summary(24)
 
 
 
 
Screening(15)
 
 
BioActivity Types:
Potency(238)
 
 
 
 
IC50(121)
 
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 427    Data Row: 573   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103165086]
IC50 0.086DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) [AID625236, Type: confirmatory]Carbonic anhydrase 2 [gi:115456]
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2
[SID103165086]
IC50 0.225Inhibition of human recombinant MAO-B after 15 mins [AID501302, Type: Literature]Amine oxidase [flavin-containing] B [gi:113980]
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3
[SID144205673]
Potency-Replicate_1 1.8996qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743094, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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4
[SID144205673]
Ratio Potency (uM) 2.05113qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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5
[SID103165086]
IC50 2.22DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55) [AID625207, Type: confirmatory]Sodium-dependent noradrenaline transporter [gi:128616]
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6
[SID103165086]
IC50 2.7Inhibition of PGDH (unknown origin) [AID1063371, Type: Literature]15-hydroxyprostaglandin dehydrogenase [NAD(+)] [gi:129889]
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7
[SID103165086]
EC50 3In vitro transcriptional activation of Peroxisome proliferator activated receptor gamma (PPAR) expressed in CV-1 cells [AID157283, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432235]
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8
[SID103165086]
EC50 3Transactivation activity at Homo sapiens (human) PPARgamma [AID1096157, Type: confirmatory]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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9
[SID103165086]
IC50 3.047DRUGMATRIX: Adenosine A3 radioligand binding (ligand: AB-MECA) [AID625196, Type: confirmatory]Adenosine receptor A3 [gi:1351831]
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10
[SID103165086]
IC50 4.655DRUGMATRIX: Protein Tyrosine Kinase, EGF Receptor enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625184, Type: confirmatory]Epidermal growth factor receptor [gi:2811086]
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11
[SID144205673]
Potency-Replicate_1 6.6824qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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12
[SID144205673]
Ratio Potency (uM) 8.21714qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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13
[SID144205673]
Potency 8.4144qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID144205673]
Potency-Replicate_1 10.5909qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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15
[SID144205673]
Potency-Replicate_1 11.8832qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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16
[SID144205673]
Potency-Replicate_1 11.8832qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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17
[SID103165086]
IC50 12.576DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: confirmatory]Substance-K receptor [gi:229462950]
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18
[SID103165086]
IC50 13.258DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) [AID625202, Type: confirmatory]Alpha-2B adrenergic receptor [gi:613504690]
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19
[SID26752161]
Potency 14.1254Confirmation Assay for Identification of Novel General Anesthetics [AID489008, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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20
[SID103165086]
EC50 14.9Agonist activity at human PPARgamma expressed in mouse NIH/3T3 cells assessed as receptor activation after 16 hrs by luciferase based reporter gene assay [AID358948, Type: Literature]Peroxisome proliferator-activated receptor gamma [gi:13432234]
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