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Digitoxigenin (CID 274159) - Compound BioActivity Data
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BioActivity Outcomes:
Active(69)
 
 
Inactive(325)
 
 
Inconclusive(10)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(14)
 
 
 
Death TRAILR..(12)
 
 
 
 
7TM GPCR Srsx(11)
 
 
 
Alpha TIF(5)
 
 
MH2 SMAD 2 3(4)
 
 
 
BioAssay Types:
Screening(239)
 
 
 
 
Confirmatory(158)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(80)
 
 
 
 
 
AC50(5)
 
 
 
 
IC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 371    Data Row: 413   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92763810]
IC50 0.05A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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2
[SID92763810]
Potency 0.2593Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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3
[SID92763810]
Potency 0.2818qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
View
4
[SID92763810]
AbsAC35_uM 0.375HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720588, Type: confirmatory]
View
5
[SID92763810]
AbsAC35_uM 0.385Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_CherryPick_Activity [AID720587, Type: confirmatory]
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6
[SID92763810]
AbsAC35_uM 0.391Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
View
7
[SID92763810]
Potency 0.4109Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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8
[SID92763810]
Potency 0.4467qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
View
9
[SID92763810]
Potency 0.8913qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
View
10
[SID92763810]
Potency 1.122qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
View
11
[SID92763810]
Potency 1.1582qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
View
12
[SID92763810]
AbsAC35_uM 1.17HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720589, Type: confirmatory]
View
13
[SID92763810]
Potency 1.2995qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
14
[SID92763810]
Potency 1.4581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
15
[SID92763810]
CC50 1.65Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
View
16
[SID92763810]
AC50_uM 2.09HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
17
[SID92763810]
Potency 2.5929qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
View
18
[SID92763810]
Potency 3.9811qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
19
[SID92763810]
Potency 5.0119qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
20
[SID92763810]
Potency 5.8048A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
View
21
[SID92763810]
Max_Activity_Conc_uM 8Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent TC71 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-04_Inhibitor_Dose_CherryPick_Activity [AID720570, Type: confirmatory]
View
22
[SID92763810]
Potency 16.3601qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
23
[SID92763810]
uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay [AID588850, Type: screening]cystic fibrosis transmembrane conductance regulator [Homo sapiens] [gi:90421313]
View
24
[SID92763810]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) [AID588354, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
View
25
[SID92763810]
Luminescence-based cell-based high throughput confirmation assay for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1). [AID588820, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
View
26
[SID92763810]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
View
27
[SID92763810]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
View
28
[SID92763810]
Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
View
29
[SID92763810]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
30
[SID92763810]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
31
[SID92763810]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
32
[SID92763810]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
View
33
[SID92763810]
Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify nonselective inhibitors of the Steroidogenic acute regulatory protein (StAR) promoter or luminescence assay artifacts [AID651611, Type: screening]
View
34
[SID92763810]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
View
35
[SID92763810]
MLPCN PGC1a Modulators Measured in Cell-Based System Using Plate Reader - 2139-01_Inhibitor_SinglePoint_HTS_Activity [AID651687, Type: screening]
View
36
[SID92763810]
uHTS determination of small molecule cytotoxicity in a fluorescence assay to identify cystic fibrosis induced NFkb Inhibitors [AID602141, Type: screening]
View
37
[SID142233]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line [AID15, Type: confirmatory]
View
38
[SID142233]
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line [AID19, Type: confirmatory]
View
39
[SID92763810]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
View
40
[SID92763810]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504539, Type: confirmatory]
View
41
[SID92763810]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_CherryPick_Activity [AID504592, Type: confirmatory]
View
42
[SID92763810]
7011-01_Antagonist_SinglePoint_HTS_Activity [AID720647, Type: screening]
View
43
[SID142233]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line [AID7, Type: confirmatory]
View
44
[SID142233]
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line [AID119, Type: confirmatory]
View
45
[SID142233]
NCI human tumor cell line growth inhibition assay. Data for the MOLT-4 Leukemia cell line [AID123, Type: confirmatory]
View
46
[SID142233]
NCI human tumor cell line growth inhibition assay. Data for the RXF 393 Renal cell line [AID133, Type: confirmatory]
View
47
[SID142233]
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line [AID139, Type: confirmatory]
View
48
[SID142233]
NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line [AID145, Type: confirmatory]
View
49
[SID92763810]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
View
50
[SID92763810]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
View