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BioActivity Data for Compound NSC119915 (CID 274127)

BioActivity Outcomes:
Active(34)
 
 
Inactive(153)
 
 
Inconclusive(11)
 
 
Unspecified(13)
 
 
Top Targets:
p450(9)
 
 
HSD10-like SD..(4)
 
 
STAT bind(3)
 
 
 
 
ANK(3)
 
 
ampC(2)
 
 
 
BioAssay Types:
Confirmatory(147)
 
 
 
 
 
Literature(25)
 
 
 
 
Screening(7)
 
 
 
BioAssay Categories:
In vitro(3)
 
 
In vivo(2)
 
 
Biochemical(12)
 
 
 
Toxicity(2)
 
 
Cell-based(14)
 
 
 
 
BioActivity Types:
Potency(60)
 
 
 
 
 
IC50(6)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 201    Data Row: 211   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160698698]
Ki 0.07Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by Lineweaver-Burk plot analysis [AID673294, Type: Literature]
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2
[SID160698698]
Ki 0.08Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by Lineweaver-Burk plot analysis [AID673295, Type: Literature]
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3
[SID160698698]
IC50 0.1Inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by spectrofluorimetric analysis [AID673292, Type: Literature]
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4
[SID160698698]
IC50 0.24Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by spectrofluorimetric analysis [AID673293, Type: Literature]
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5
[SID160698698]
IC50 0.33Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate in presence of recombinant superoxide dismutase [AID673296, Type: Literature]
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6
[SID26514298]
IC50 0.578In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study [AID1072, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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7
[SID4253663]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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8
[SID4253663]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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9
[SID124878170]
Potency 1.4125qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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10
[SID124878170]
Potency 1.6947qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds [AID720540, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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11
[SID4253663]
Potency 2.5119qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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12
[SID4253663]
Potency 2.5119qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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13
[SID50109016]
Potency 2.8184qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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14
[SID4253663]
Potency 3.1623qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase, partial [Homo sapiens] [gi:1832253]
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15
[SID26514298]
IC50 3.98In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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16
[SID26514298]
IC50 3.98In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 2 [Homo sapiens] [gi:24234686]
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17
[SID4253663]
Potency 10Confirmation Concentration-Response Assay for Identification of Small Molecule Antagonists of Stat Signaling Pathway [AID922, Type: confirmatory]signal transducer and activator of transcription 6, interleukin-4 induced [Homo sapiens] [gi:15724400]
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18
[SID124878170]
Potency 16.9469qHTS for Inhibitors of the Phosphatase Activity of Eya2: Carboxyl-terminal binding protein (CtBP) Counterscreen for Cherry-picked Compounds [AID720541, Type: confirmatory]C-terminal-binding protein 1 [gi:6014741]
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19
[SID124878170]
Potency 56.2341qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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20
[SID160698698]
Reversible inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) assessed as residual activity of enzyme measured after 10 fold dilution at 100 uM preincubated for 20 mins [AID673291, Type: Literature]
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