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NSC119915 (CID 274127) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(153)
 
 
Inconclusive(11)
 
 
Unspecified(13)
 
 
Top Targets:
p450(9)
 
 
HSD10-like SD..(4)
 
 
ANK(3)
 
 
STAT6 C(3)
 
 
 
 
PLDc mTdp1 2(2)
 
 
BioAssay Types:
Confirmatory(147)
 
 
 
 
 
Literature(25)
 
 
 
 
Screening(7)
 
 
 
BioActivity Types:
Potency(60)
 
 
 
 
 
IC50(6)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 201    Data Row: 211   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160698698]
Ki 0.07Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by Lineweaver-Burk plot analysis [AID673294, Type: Literature]
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2
[SID160698698]
Ki 0.08Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by Lineweaver-Burk plot analysis [AID673295, Type: Literature]
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3
[SID160698698]
IC50 0.1Inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by spectrofluorimetric analysis [AID673292, Type: Literature]
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4
[SID160698698]
IC50 0.24Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by spectrofluorimetric analysis [AID673293, Type: Literature]
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5
[SID160698698]
IC50 0.33Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate in presence of recombinant superoxide dismutase [AID673296, Type: Literature]
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6
[SID26514298]
IC50 0.578In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study [AID1072, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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7
[SID4253663]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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8
[SID4253663]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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9
[SID124878170]
Potency 1.4125qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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10
[SID124878170]
Potency 1.6947qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds [AID720540, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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11
[SID4253663]
Potency 2.5119qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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12
[SID4253663]
Potency 2.5119qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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13
[SID50109016]
Potency 2.8184qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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14
[SID4253663]
Potency 3.1623qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase, partial [Homo sapiens] [gi:1832253]
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15
[SID26514298]
IC50 3.98In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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16
[SID26514298]
IC50 3.98In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 2 [Homo sapiens] [gi:24234686]
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17
[SID4253663]
Potency 10Confirmation Concentration-Response Assay for Identification of Small Molecule Antagonists of Stat Signaling Pathway [AID922, Type: confirmatory]signal transducer and activator of transcription 6, interleukin-4 induced [Homo sapiens] [gi:15724400]
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18
[SID124878170]
Potency 16.9469qHTS for Inhibitors of the Phosphatase Activity of Eya2: Carboxyl-terminal binding protein (CtBP) Counterscreen for Cherry-picked Compounds [AID720541, Type: confirmatory]C-terminal-binding protein 1 [gi:6014741]
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19
[SID124878170]
Potency 56.2341qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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20
[SID160698698]
Increase of ROS level in human PC3 cells expressing Cdc25A-C using H2DCFDA at 20 uM after 30 mins by flow cytometry [AID673322, Type: Literature]
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