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NSC119915 (CID 274127) - Compound BioActivity Data
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BioActivity Outcomes:
Active(34)
 
 
Inactive(153)
 
 
Inconclusive(11)
 
 
Unspecified(13)
 
 
Top Targets:
p450(9)
 
 
HSD10-like SD..(4)
 
 
ANK(3)
 
 
STAT6 C(3)
 
 
 
 
PLDc mTdp1 2(2)
 
 
BioAssay Types:
Confirmatory(147)
 
 
 
 
 
Literature(25)
 
 
 
 
Screening(7)
 
 
 
BioActivity Types:
Potency(60)
 
 
 
 
 
IC50(6)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 201    Data Row: 211   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160698698]
Ki 0.07Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by Lineweaver-Burk plot analysis [AID673294, Type: Literature]
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2
[SID160698698]
Ki 0.08Competitive inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by Lineweaver-Burk plot analysis [AID673295, Type: Literature]
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3
[SID160698698]
IC50 0.1Inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by spectroflurimetric analysis [AID673292, Type: Literature]
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4
[SID160698698]
IC50 0.24Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate by spectroflurimetric analysis [AID673293, Type: Literature]
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5
[SID160698698]
IC50 0.33Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate in presence of recombinant superoxide dismutase [AID673296, Type: Literature]
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6
[SID26514298]
IC50 0.578In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study [AID1072, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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7
[SID4253663]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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8
[SID4253663]
Potency 0.631qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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9
[SID124878170]
Potency 1.4125qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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10
[SID124878170]
Potency 1.6947qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds [AID720540, Type: confirmatory]eyes absent homolog 2 isoform a [Homo sapiens] [gi:26667227]
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11
[SID4253663]
Potency 2.5119qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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12
[SID4253663]
Potency 2.5119qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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13
[SID50109016]
Potency 2.8184qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 [Homo sapiens] [gi:31542939]
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14
[SID4253663]
Potency 3.1623qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase) [AID887, Type: confirmatory]15-lipoxygenase [Homo sapiens] [gi:1832253]
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15
[SID26514298]
IC50 3.98In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
View
16
[SID26514298]
IC50 3.98In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 2 [Homo sapiens] [gi:24234686]
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17
[SID4253663]
Potency 10Confirmation Concentration-Response Assay for Identification of Small Molecule Antagonists of Stat Signaling Pathway [AID922, Type: confirmatory]signal transducer and activator of transcription 6, interleukin-4 induced [Homo sapiens] [gi:15724400]
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18
[SID124878170]
Potency 16.9469qHTS for Inhibitors of the Phosphatase Activity of Eya2: Carboxyl-terminal binding protein (CtBP) Counterscreen for Cherry-picked Compounds [AID720541, Type: confirmatory]C-terminal-binding protein 1 [gi:6014741]
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19
[SID124878170]
Potency 56.2341qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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20
[SID160698698]
Increase of ROS level in human PC3 cells expressing Cdc25A-C using H2DCFDA at 20 uM after 30 mins by flow cytometry [AID673322, Type: Literature]
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21
[SID160698698]
Inhibition of Cdc25B assessed as decrease in enzyme level at 400 uM after 60 mins by SDS-PAGE analysis [AID673297, Type: Literature]
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22
[SID160698698]
Growth inhibition against human MCF7 cells expressing Cdc25A-C assessed as cell viability at 20 uM after 72 hrs by MTS assay [AID673299, Type: Literature]
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23
[SID160698698]
Growth inhibition against human PC3 cells expressing Cdc25A-C assessed as cell viability at 20 uM after 72 hrs by MTS assay [AID673302, Type: Literature]
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24
[SID160698698]
Growth inhibition against human K562 cells expressing Cdc25A-C assessed as cell viability at 20 uM after 72 hrs by MTS assay [AID673305, Type: Literature]
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25
[SID160698698]
Increase of ROS level in human K562 cells expressing Cdc25A-C using H2DCFDA at 20 uM after 30 mins by flow cytometry [AID673308, Type: Literature]
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26
[SID4253663]
qHTS Assay for Spectroscopic Profiling in Fluorescein Spectral Region [AID593, Type: other]
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27
[SID4253663]
qHTS Assay for Inhibitors of DNA Polymerase III Holoenzyme System [AID603, Type: confirmatory]
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28
[SID8139589]
HIV-2 RNase H Inhibition [AID367, Type: screening]Chain A, Crystal Structure Of Hiv-2 Reverse Transcriptase [gi:24987805]
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29
[SID160698698]
Reversible inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) assessed as residual activity of enzyme measured after 10 fold dilution at 100 uM preincubated for 20 mins [AID673291, Type: Literature]
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30
[SID160698698]
Inhibition of Cdc25B in human K562 cells assessed as increase in Cdk1 phosphorylation at 20 uM after 24 hrs by Western blot analysis [AID673315, Type: Literature]M-phase inducer phosphatase 2 [gi:21264471]
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31
[SID8139589]
human RNase H Inhibition [AID366, Type: screening]ribonuclease H1 isoform 1 precursor [Homo sapiens] [gi:21359816]
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32
[SID4253663]
qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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33
[SID4253663]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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34
[SID8139589]
E. coli RNase H Inhibition [AID365, Type: screening]Ribonuclease HI [gi:67472286]
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35
[SID4253663]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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36
[SID414520]
NCI AIDS Antiviral Assay [AID179, Type: confirmatory]
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37
[SID160698698]
Cell cycle arrest in human MCF7 cells assessed as accumulation at G1 phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 81.3 +/- 0.01%) [AID673309, Type: Literature]
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38
[SID160698698]
Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 9.4 +/- 0.04%) [AID673313, Type: Literature]
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39
[SID160698698]
Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 20 uM after 24 hrs by propidium iodide staining-based flow cytometry (Rvb = 9.35%) [AID673314, Type: Literature]
View
40
[SID160698698]
Inhibition of Cdc25B assessed as decrease in enzyme level after 30 mins by SDS-PAGE analysis [AID673298, Type: Literature]
View
41
[SID160698698]
Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate at 100 uM after 15 mins by fluorimetric assay [AID673288, Type: Literature]
View
42
[SID160698698]
Inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate at 100 uM after 15 mins by fluorimetric assay [AID673289, Type: Literature]
View
43
[SID160698698]
Inhibition of recombinant phosphatase activity of Cdc25C catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate at 100 uM after 15 mins by fluorimetric assay [AID673290, Type: Literature]
View
44
[SID160698698]
Cell cycle arrest in human MCF7 cells assessed as accumulation at G1 phase at 20 uM after 48 hrs by propidium iodide staining-based flow cytometry (Rvb = 64.5 +/- 0.02%) [AID673327, Type: Literature]
View
45
[SID160698698]
Cell cycle arrest in human MCF7 cells assessed as accumulation at S phase at 20 uM after 48 hrs by propidium iodide staining-based flow cytometry (Rvb = 14.5 +/- 0.01%) [AID673328, Type: Literature]
View
46
[SID160698698]
Cell cycle arrest in human MCF7 cells assessed as accumulation at G2/M phase at 20 uM after 48 hrs by propidium iodide staining-based flow cytometry (Rvb = 21 +/- 0.04%) [AID673329, Type: Literature]
View
47
[SID124878170]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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48
[SID124878170]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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49
[SID124878170]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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50
[SID124878170]
Potency qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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