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NSC119913 (CID 274125) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(67)
 
 
Unspecified(6)
 
 
Top Targets:
HSPA1-2 6-8-l..(2)
 
 
RVT connect(1)
 
 
RNase HI euka..(1)
 
 
CAP ED(1)
 
 
RNase HI prok..(1)
 
 
BioAssay Types:
Confirmatory(62)
 
 
 
 
Literature(8)
 
 
 
 
Screening(3)
 
 
BioActivity Types:
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 81    Data Row: 82   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26514300]
IC50 0.634In Vitro Hsp70 Dose Response Fluorescence Polarization Assay for SAR Study [AID1072, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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2
[SID26514300]
IC50 5.58In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 2 [Homo sapiens] [gi:24234686]
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3
[SID26514300]
IC50 5.58In Vitro Hsc70 Dose Response Fluorescence Polarization Assay [AID1193, Type: confirmatory]heat shock cognate 71 kDa protein isoform 1 [Homo sapiens] [gi:5729877]
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4
[SID103649564]
IC50 43Inhibition of Escherichia coli MurD assessed as blockade of addition of D-[14C]Glu to UDP-MurNAc-L-Ala [AID393934, Type: Literature]
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5
[SID8139588]
human RNase H Inhibition [AID366, Type: screening]ribonuclease H1 isoform 1 precursor [Homo sapiens] [gi:21359816]
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6
[SID103649564]
Reversible inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) assessed as residual activity of enzyme measured after 10 fold dilution at 100 uM preincubated for 20 mins [AID673291, Type: Literature]
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7
[SID8139588]
HIV-2 RNase H Inhibition [AID367, Type: screening]Chain A, Crystal Structure Of Hiv-2 Reverse Transcriptase [gi:24987805]
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8
[SID8139588]
E. coli RNase H Inhibition [AID365, Type: screening]Ribonuclease HI [gi:67472286]
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9
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the CCRF-CEM Leukemia cell line [AID119, Type: confirmatory]
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10
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line [AID55, Type: confirmatory]
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11
[SID414518]
NCI AIDS Antiviral Assay [AID179, Type: confirmatory]
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12
[SID103649564]
Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate at 100 uM after 15 mins by fluorimetric assay [AID673288, Type: Literature]
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13
[SID103649564]
Inhibition of recombinant phosphatase activity of Cdc25B catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate at 100 uM after 15 mins by fluorimetric assay [AID673289, Type: Literature]
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14
[SID103649564]
Inhibition of recombinant phosphatase activity of Cdc25C catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate at 100 uM after 15 mins by fluorimetric assay [AID673290, Type: Literature]
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15
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line [AID15, Type: confirmatory]
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16
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line [AID19, Type: confirmatory]
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17
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the EKVX Non-Small Cell Lung cell line [AID21, Type: confirmatory]
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18
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line [AID23, Type: confirmatory]
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19
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line [AID25, Type: confirmatory]
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20
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line [AID31, Type: confirmatory]
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21
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the UACC-257 Melanoma cell line [AID33, Type: confirmatory]
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22
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-2 Melanoma cell line [AID35, Type: confirmatory]
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23
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line [AID37, Type: confirmatory]
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24
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line [AID39, Type: confirmatory]
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25
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the PC-3 Prostate cell line [AID41, Type: confirmatory]
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26
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line [AID43, Type: confirmatory]
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27
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line [AID45, Type: confirmatory]
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28
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line [AID47, Type: confirmatory]
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29
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line [AID53, Type: confirmatory]
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30
[SID103649564]
Antibacterial activity against Escherichia coli 1411 after 18 hrs by broth microdilution method [AID393936, Type: Literature]
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31
[SID103649564]
Antibacterial activity against AcrAB deficient Escherichia coli SM1411 after 18 hrs by broth microdilution method [AID393937, Type: Literature]
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32
[SID103649564]
Antibacterial activity against Staphylococcus aureus 8325-4 after 18 hrs by broth microdilution method [AID393938, Type: Literature]
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33
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line [AID1, Type: confirmatory]
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34
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H226 Non-Small Cell Lung cell line [AID3, Type: confirmatory]
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35
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H322M Non-Small Cell Lung cell line [AID5, Type: confirmatory]
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36
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line [AID7, Type: confirmatory]
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37
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line [AID9, Type: confirmatory]
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38
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line [AID13, Type: confirmatory]
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39
[SID414518]
NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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40
[SID414518]
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID330, Type: other]
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41
[SID10319316]
HERG Channel Activity [AID376, Type: other]potassium voltage-gated channel subfamily H member 2 isoform a [Homo sapiens] [gi:4557729]
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42
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line [AID59, Type: confirmatory]
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43
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the HT29 Colon cell line [AID65, Type: confirmatory]
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44
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the COLO 205 Colon cell line [AID67, Type: confirmatory]
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45
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the HCT-15 Colon cell line [AID71, Type: confirmatory]
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46
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the KM12 Colon cell line [AID73, Type: confirmatory]
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47
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Colon cell line [AID77, Type: confirmatory]
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48
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Colon cell line [AID79, Type: confirmatory]
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49
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the SW-620 Colon cell line [AID81, Type: confirmatory]
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50
[SID414518]
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line [AID83, Type: confirmatory]
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