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Tamoxifen (CID 2733526) - Compound BioActivity Data
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BioActivity Outcomes:
Active(360)
 
 
Inactive(713)
 
 
Inconclusive(145)
 
 
Unspecified(2046)
 
 
Top Targets:
NR LBD ER(199)
 
 
 
 
 
7tm 4(71)
 
 
 
 
 
p450(32)
 
 
 
 
 
NR LBD PPAR(16)
 
 
 
 
NR LBD AR(15)
 
 
 
 
BioAssay Types:
Literature(753)
 
 
 
 
 
Confirmatory(586)
 
 
 
 
 
Screening(359)
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(454)
 
 
 
 
 
IC50(289)
 
 
 
 
 
Ki(18)
 
 
 
EC50(12)
 
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2933    Data Row: 3264   Total Pages: 164   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103170100]
EC50 0.00011Effective dose for [3H]- estradiol against proliferation of MCF-7 cells [AID102435, Type: Literature]
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2
[SID103170100]
Ki 0.00051Displacement of [3H]estradiol from ERbeta after 4 hrs by scintillation counting [AID669589, Type: Literature]
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3
[SID103170100]
Kd 0.001Binding affinity towards antiestrogen binding site AEBS [AID38728, Type: Literature]
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4
[SID103170100]
Ki 0.0028Binding affinity to emopamil binding protein (unknown origin) [AID723649, Type: Literature]Emopamil-binding protein-like [gi:18202741]
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5
[SID103170100]
Ki 0.005Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand [AID239597, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:17374795]
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6
[SID103170100]
IC50 0.0084Displacement of radioligand from Estrogen receptor alpha [AID70499, Type: Literature]
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7
[SID103170100]
EC50 0.01Effective concentration against MCF-7 breast tumor cells using MCF-7 assay. [AID103375, Type: Literature]
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8
[SID103170100]
Ki 0.0119Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor beta [gi:6166154]
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9
[SID103170100]
Ki 0.0119Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol) [AID68906, Type: Literature]Estrogen receptor [gi:544257]
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10
[SID103170100]
IC50 0.012Displacement of [3H]tamoxifen from antiestrogen binding site (AEBS) [AID38614, Type: Literature]7-dehydrocholesterol reductase [gi:20138066]
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11
[SID103170100]
IC50 0.012Displacement of [3H]tamoxifen from antiestrogen binding site (AEBS) [AID38614, Type: Literature]3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase [gi:17374795]
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12
[SID103170100]
IC50 0.021DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: confirmatory]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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13
[SID103170100]
IC50 0.027Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID657123, Type: Literature]
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14
[SID103170100]
Ki 0.03119Displacement of [2,4,6,7-3H]estradiol from human ERalpha expressed in HeLa cells after 18 hrs by liquid scintillation counting [AID497602, Type: Literature]Estrogen receptor [gi:544257]
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15
[SID103170100]
EC50 0.033Concentration of compound required to induce 50 % of the maximum stimulation of alkaline phosphatase activity in Ishikawa cells [AID91597, Type: Literature]
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16
[SID103170100]
Ki 0.0344Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68910, Type: Literature]Estrogen receptor [gi:544257]
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17
[SID103170100]
Ki 0.0344Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol [AID68910, Type: Literature]Estrogen receptor beta [gi:6166154]
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18
[SID103170100]
Ki 0.035Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand [AID239347, Type: Literature]
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19
[SID103170100]
IC50 0.039Antagonist activity at Gal4 DBD-fused human ERalpha LBD expressed in HEK293T cells assessed as inhibition of estradiol-induced transcriptional activation after 20 hrs by luciferase reporter gene assay [AID759306, Type: Literature]Estrogen receptor [gi:544257]
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20
[SID103170100]
IC50 0.042Displacement of [3H]17-beta-estradiol from human estrogen receptor alpha [AID70341, Type: Literature]Estrogen receptor [gi:544257]
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