Tamoxifen (CID 2733525) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(260)
 
 
Inactive(777)
 
 
Inconclusive(292)
 
 
Unspecified(43)
 
 
Top Targets:
p450(24)
 
 
 
 
 
7TM GPCR Srx(15)
 
 
 
NR LBD TR(14)
 
 
 
PLN02808(12)
 
 
P53(11)
 
 
 
 
BioAssay Types:
Confirmatory(645)
 
 
 
 
 
Screening(330)
 
 
 
 
Literature(104)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(484)
 
 
 
 
 
IC50(22)
 
 
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 850    Data Row: 1372   Total Pages: 28   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389724]
Potency 2.8184qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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2
[SID17389724]
Potency 2.8184qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID17389724]
Potency 2.8184qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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4
[SID17389724]
Potency 2.8184qHTS assay for small molecule antagonists of estrogen receptor alpha signaling [AID588513, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID50107133]
Potency 3.1623qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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6
[SID50107133]
Potency 3.1623qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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7
[SID50107133]
Potency 3.1623qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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8
[SID50107133]
Potency 3.1623qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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9
[SID50107133]
Potency 3.1623qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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10
[SID49816809]
Potency 3.1623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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11
[SID50107133]
Potency 3.5481qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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12
[SID11112088]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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13
[SID11112088]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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14
[SID11112087]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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15
[SID11112087]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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16
[SID11112087]
Potency 3.9811qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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17
[SID49816809]
AC50 4.531Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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18
[SID49816809]
AC50 6.687Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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19
[SID17389724]
Potency 7.0795qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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20
[SID17389724]
Potency 7.0795qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
View
21
[SID17389724]
Potency 7.0795qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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22
[SID17389724]
Potency 7.0795qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
View
23
[SID17389724]
Potency 7.0795qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]KCNH2 gene product [Homo sapiens] [gi:325651834]
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24
[SID11112088]
Potency 7.0795qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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25
[SID49816809]
Potency 7.3753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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26
[SID103207344]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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27
[SID50107133]
Potency 7.9433qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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28
[SID50107133]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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29
[SID103207344]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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30
[SID103207344]
IC50 10Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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31
[SID103207344]
IC50 10Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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32
[SID11112087]
Potency 10qHTS Assay for Identification of Small Molecule Antagonists for Thrombopoietin (TPO) Signaling Pathway [AID918, Type: confirmatory]Thrombopoietin [Homo sapiens] [gi:120660324]
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33
[SID26747686]
Potency 10qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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34
[SID103207344]
IC50 10.2Cytotoxicity against human MCF7 cells after 18 hrs by MTT assay [AID451960, Type: Literature]
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35
[SID50107133]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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36
[SID50107133]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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37
[SID50107133]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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38
[SID50107133]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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39
[SID103207344]
IC50 12.3Cytotoxicity against human MDA-MB-231 cells after 18 hrs by MTT assay [AID451961, Type: Literature]
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40
[SID103207344]
IC50 12.5Cytotoxicity against human Ishikawa cells after 18 hrs by MTT assay [AID451962, Type: Literature]
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41
[SID103207344]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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42
[SID103207344]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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43
[SID103207344]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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44
[SID50107133]
Potency 12.5893qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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45
[SID85231332]
Potency 13.1154Quantitative high throughput screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID488745, Type: confirmatory]
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46
[SID144204489]
Potency 14.9631qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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47
[SID144204489]
Potency 14.9631qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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48
[SID144204489]
Potency 14.9631qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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49
[SID103207344]
IC50 15.25Cytotoxicity against human DU145 cells after 18 hrs by MTT assay [AID451964, Type: Literature]
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50
[SID49816809]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
View