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BioActivity Data for Compound Chlorpyrifos (CID 2730)

BioActivity Outcomes:
Active(39)
 
 
Inactive(822)
 
 
Inconclusive(114)
 
 
Unspecified(380)
 
 
Top Targets:
NR LBD PPAR(36)
 
 
 
7tm 4(34)
 
 
NR LBD TR(24)
 
 
 
NR LBD AR(22)
 
 
 
NR LBD ER(22)
 
 
 
BioAssay Types:
Confirmatory(547)
 
 
 
 
 
Screening(303)
 
 
 
Literature(223)
 
 
 
 
 
Summary(54)
 
 
 
 
BioAssay Categories:
In vitro(4)
 
 
In vivo(212)
 
 
 
 
Biochemical(97)
 
 
 
Toxicity(264)
 
 
 
 
 
ADME(27)
 
 
Cell-based(95)
 
 
 
 
Organism-base..(9)
 
 
BioActivity Types:
Potency(539)
 
 
 
 
 
IC50(10)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1053    Data Row: 1355   Total Pages: 68   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103579773]
IC50 1.83Inhibition of acetylcholinesterase in Drosophila melanogaster brain by Ellman's method [AID1092102, Type: Literature]Acetylcholinesterase [gi:113036]
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2
[SID17389921]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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3
[SID144209581]
Potency-Replicate_1 6.8729qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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4
[SID103579773]
IC50 9.51Inhibition of acetylcholinesterase in Musca domestica (house fly) brain by Ellman's method [AID1092101, Type: Literature]Acetylcholinesterase [gi:75012521]
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5
[SID144210468]
AhR Potency (uM) 9.68854qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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6
[SID144210468]
Potency-Replicate_1 10.8707qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID144209581]
Potency-Replicate_1 13.7133qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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8
[SID26613395]
Active Concentration 20Modulators of the EP2 prostaglandin EP2 receptor - Primary Dose Response [AID1421, Type: confirmatory]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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9
[SID144209581]
AhR Potency (uM) 26.8416qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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10
[SID26753020]
Potency 27.306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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11
[SID144209581]
Potency-Replicate_1 27.3616qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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12
[SID144209581]
Potency-Replicate_1 27.3616qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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13
[SID49731957]
Potency 29.9349qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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14
[SID26753019]
Potency 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
View
15
[SID144210468]
Potency-Replicate_1 30.6379qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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16
[SID144210468]
Ratio Potency (uM) 30.6379qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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17
[SID26747367]
Potency 31.6228Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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18
[SID144210468]
Ratio Potency (uM) 34.3762qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
View
19
[SID26747367]
Potency 35.4813qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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20
[SID17389921]
Potency 37.578qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
View