Chlorpyrifos (CID 2730) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(19)
 
 
Inactive(585)
 
 
Inconclusive(59)
 
 
Unspecified(44)
 
 
Top Targets:
NR LBD PPAR(20)
 
 
 
NR LBD TR(18)
 
 
 
7TM GPCR Srx(14)
 
 
NR LBD VDR(10)
 
 
 
 
NR LBD AR(8)
 
 
 
BioAssay Types:
Confirmatory(354)
 
 
 
 
 
Screening(255)
 
 
 
Literature(44)
 
 
 
 
 
BioActivity Types:
Potency(305)
 
 
 
 
 
IC50(8)
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 568    Data Row: 707   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389921]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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2
[SID17389921]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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3
[SID17389921]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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4
[SID26613395]
Active Concentration 20Modulators of the EP2 prostaglandin EP2 receptor - Primary Dose Response [AID1421, Type: confirmatory]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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5
[SID26613395]
Active Concentration 20Modulators of the EP2 prostaglandin EP2 receptor - Primary Dose Response [AID1421, Type: confirmatory]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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6
[SID26753020]
Potency 27.306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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7
[SID26753020]
Potency 27.306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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8
[SID26753020]
Potency 27.306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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9
[SID26753020]
Potency 27.306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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10
[SID26753019]
Potency 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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11
[SID26753019]
Potency 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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12
[SID26753019]
Potency 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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13
[SID26753019]
Potency 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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14
[SID26747367]
Potency 31.6228Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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15
[SID26747367]
Potency 31.6228Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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16
[SID26747367]
Potency 31.6228Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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17
[SID26747367]
Potency 31.6228Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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18
[SID26747367]
Potency 35.4813qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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19
[SID17389921]
Potency 37.578qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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20
[SID17389921]
Potency 37.578qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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21
[SID17389921]
Potency 37.578qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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22
[SID17389921]
Potency 37.578qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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23
[SID49731957]
Potency 50.1187qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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24
[SID26753021]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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25
[SID26753021]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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26
[SID26753021]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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27
[SID26753021]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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28
[SID49731957]
 Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 [AID602410, Type: screening]Kcnk3 channel [Homo sapiens] [gi:11093520]
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29
[SID48415394]
 DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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30
[SID103579773]
 Inhibition of MAGL activity in KIAA1363-deficient Swiss Webster mouse brain at 100 mg/kg, ip [AID503744, Type: Literature]
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31
[SID103579773]
 Inhibition of MAGL activity in KIAA1363-expressing Swiss Webster mouse at 100 mg/kg, ip [AID503745, Type: Literature]
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32
[SID103579773]
 Inhibition of FAAH activity in KIAA1363-deficient Swiss Webster mouse brain at 100 mg/kg, ip [AID503746, Type: Literature]
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33
[SID103579773]
 Inhibition of FAAH activity in KIAA1363-expressing Swiss Webster mouse brain at 100 mg/kg, ip [AID503747, Type: Literature]
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34
[SID26753019]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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35
[SID26613395]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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36
[SID26613395]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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37
[SID26613395]
 Modulators of the EP2 prostaglandin EP2 receptor - Primary Counterscreens [AID1080, Type: other]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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38
[SID26613395]
 Modulators of the EP2 prostaglandin EP2 receptor - Primary Counterscreens [AID1080, Type: other]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
View
39
[SID49731957]
 Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction [AID2629, Type: screening]LANA [Human herpesvirus 8] [gi:139472804]
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40
[SID103579773]
 Inhibitory activity against AChE from rat brain homogenate [AID260331, Type: Literature]Acetylcholinesterase [gi:584716]
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41
[SID49731957]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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42
[SID49731957]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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43
[SID26753019]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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44
[SID103579773]
 Disruption of endocannabinoid metabolism in KIAA1363 deficient Swiss Webster mouse brain assessed as saturated C24:0 fatty acid level per gram of tissue at 100 mg/kg, ip after 4 hrs [AID503569, Type: Literature]
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45
[SID103579773]
 Disruption of endocannabinoid metabolism in KIAA1363 deficient Swiss Webster mouse brain assessed as unsaturated C24:1 fatty acid level per gram of tissue at 100 mg/kg, ip after 4 hrs [AID503570, Type: Literature]
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46
[SID103579773]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain expressing KIAA1363 gene assessed as saturated C18:0 fatty acid level per gram of tissue at 100 mg/kg, ip after 4 hrs [AID503574, Type: Literature]
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47
[SID103579773]
 Disruption of endocannabinoid metabolism in KIAA1363 deficient Swiss Webster mouse brain assessed as saturated C18:0 fatty acid level per gram of tissue at 100 mg/kg, ip after 4 hrs [AID503575, Type: Literature]
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48
[SID17389921]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
View
49
[SID103579773]
 Disruption of endocannabinoid metabolism in KIAA1363 deficient Swiss Webster mouse brain assessed as 2-arachidonylglycerol level per gram of tissue at 100 mg/kg, ip after 4 hrs [AID503560, Type: Literature]
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50
[SID103579773]
 Disruption of endocannabinoid metabolism in KIAA1363 deficient Swiss Webster mouse brain assessed as anandamide level per gram of tissue at 100 mg/kg, ip after 4 hrs [AID503559, Type: Literature]
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