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Chlorpyrifos (CID 2730) - Compound BioActivity Data
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BioActivity Outcomes:
Active(46)
 
 
Inactive(778)
 
 
Inconclusive(109)
 
 
Unspecified(44)
 
 
Top Targets:
NR LBD PPAR(36)
 
 
 
NR LBD TR(24)
 
 
 
 
NR LBD ER(22)
 
 
 
NR LBD AR(22)
 
 
 
NR LBD VDR(18)
 
 
 
 
BioAssay Types:
Confirmatory(529)
 
 
 
 
 
Screening(302)
 
 
 
Summary(48)
 
 
 
 
Literature(44)
 
 
 
 
 
BioActivity Types:
Potency(514)
 
 
 
 
 
IC50(8)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 694    Data Row: 977   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID17389921]
Potency 5.0119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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2
[SID144209581]
Potency-Replicate_1 6.8729qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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3
[SID144210468]
AhR Potency (uM) 9.68854qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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4
[SID144210468]
Potency-Replicate_1 10.8707qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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5
[SID144209581]
Potency-Replicate_1 13.7133qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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6
[SID26613395]
Active Concentration 20Modulators of the EP2 prostaglandin EP2 receptor - Primary Dose Response [AID1421, Type: confirmatory]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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7
[SID144209581]
Potency-Replicate_1 24.6073qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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8
[SID144209581]
Potency-Replicate_1 24.6073qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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9
[SID144209581]
AhR Potency (uM) 26.8416qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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10
[SID26753020]
Potency 27.306qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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11
[SID144209581]
Potency-Replicate_1 27.3616qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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12
[SID144209581]
Potency-Replicate_1 27.3616qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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13
[SID49731957]
Potency 29.9349qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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14
[SID144210468]
Ratio Potency (uM) 30.6379qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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15
[SID144210468]
Potency-Replicate_1 30.6379qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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16
[SID26753019]
Potency 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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17
[SID144209581]
Potency-Replicate_1 30.7002qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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18
[SID144209581]
Potency-Replicate_1 30.7002qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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19
[SID26747367]
Potency 31.6228Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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20
[SID144210468]
Ratio Potency (uM) 34.3762qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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21
[SID26747367]
Potency 35.4813qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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22
[SID17389921]
Potency 37.578qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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23
[SID144209581]
Potency-Replicate_1 38.6492qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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24
[SID144209581]
Ratio Potency (uM) 39.7778qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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25
[SID144210468]
Potency-Replicate_1 43.2771qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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26
[SID144209581]
Potency-Replicate_1 43.7587qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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27
[SID144209581]
Potency-Replicate_1 49.098qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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28
[SID144209581]
Potency-Replicate_1 49.098qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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29
[SID144209581]
Potency-Replicate_1 49.098qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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30
[SID49731957]
Potency 50.1187qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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31
[SID26753021]
Potency 54.4827qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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32
[SID144209581]
Potency-Replicate_1 54.5935qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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33
[SID144209581]
Potency-Replicate_1 54.5935qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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34
[SID144209581]
Potency-Replicate_1 54.5935qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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35
[SID144209581]
Potency-Replicate_1 55.0889qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
View
36
[SID144209581]
Potency-Replicate_1 55.0889qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743217, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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37
[SID49731957]
Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction [AID2629, Type: screening]LANA [Human herpesvirus 8] [gi:139472804]
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38
[SID103579773]
Inhibition of MAGL activity in KIAA1363-deficient Swiss Webster mouse brain at 100 mg/kg, ip [AID503744, Type: Literature]
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39
[SID103579773]
Inhibition of MAGL activity in KIAA1363-expressing Swiss Webster mouse at 100 mg/kg, ip [AID503745, Type: Literature]
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40
[SID103579773]
Inhibition of FAAH activity in KIAA1363-deficient Swiss Webster mouse brain at 100 mg/kg, ip [AID503746, Type: Literature]
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41
[SID103579773]
Inhibition of FAAH activity in KIAA1363-expressing Swiss Webster mouse brain at 100 mg/kg, ip [AID503747, Type: Literature]
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42
[SID26753019]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
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43
[SID48415394]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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44
[SID49731957]
Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 [AID602410, Type: screening]Kcnk3 channel [Homo sapiens] [gi:11093520]
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45
[SID26613395]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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46
[SID26613395]
Modulators of the EP2 prostaglandin EP2 receptor - Primary Counterscreens [AID1080, Type: other]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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47
[SID103579773]
TP_TRANSPORTER: Immunohistochemisty in vivo, stomach of Fischer 344 rat [AID681497, Type: other]Multidrug resistance protein 1a [gi:81911503]
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48
[SID103579773]
TP_TRANSPORTER: Immunohistochemisty in vivo, kidney of Fischer 344 rat [AID681498, Type: other]Multidrug resistance protein 1a [gi:81911503]
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49
[SID103579773]
TP_TRANSPORTER: Immunohistochemisty in vivo, jejunum of Fischer 344 rat [AID681499, Type: other]Multidrug resistance protein 1a [gi:81911503]
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50
[SID103579773]
TP_TRANSPORTER: Immunohistochemisty in vivo, adrenals of Fischer 344 rat [AID681500, Type: other]Multidrug resistance protein 1a [gi:81911503]
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