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Chlorpheniramine (CID 2725) - Compound BioActivity Data
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BioActivity Outcomes:
Active(23)
 
 
Inactive(94)
 
 
Inconclusive(7)
 
 
Unspecified(1148)
 
 
Top Targets:
ABC MTABC3 MD..(5)
 
 
CAP ED(4)
 
 
 
Pyr redox dim(4)
 
 
7TM GPCR Srx(4)
 
 
PIKKc TOR(4)
 
 
BioAssay Types:
Literature(134)
 
 
 
 
Confirmatory(77)
 
 
 
Screening(17)
 
 
BioActivity Types:
Potency(76)
 
 
 
IC50(20)
 
 
 
 
Ki(4)
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1264    Data Row: 1272   Total Pages: 64   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103173276]
Ki 0.002Ability to displace [3H]pyrilamine from histamine H1 receptor in male Sprague-Dawley rat brain membranes [AID87525, Type: Literature]
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2
[SID103173276]
Kd 0.0037Dissociation constant (KD) of the compound [AID17268, Type: Literature]
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3
[SID103173276]
Kd 0.00398pA2 value is determined compared to standard H1-antagonists [AID24863, Type: Literature]
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4
[SID103173276]
Ki 0.0055Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes [AID87519, Type: Literature]
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5
[SID103173276]
Ki 0.0055Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand [AID87521, Type: Literature]
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6
[SID103173276]
Ki 0.007Binding affinity to histamine H1 receptor [AID591511, Type: Literature]
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7
[SID103173276]
IC50 0.0088Inhibition of [3H]mepyramine binding to the Histamine H1 receptor in guinea pig cortex [AID86586, Type: Literature]Histamine H1 receptor [gi:399889]
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8
[SID103173276]
IC50 0.066Displacement of [3H]pyrilamine from human histamine receptor subtype 1 expressed in CHO cells [AID351895, Type: Literature]Histamine H1 receptor [gi:547645]
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9
[SID103173276]
IC50 1.1Inhibitory concentration against IKr potassium channel [AID240820, Type: Literature]
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10
[SID103173276]
IC50 3.9Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum Dd2 infected human erythrocytes by SYBR green assay [AID351890, Type: Literature]
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11
[SID103173276]
IC50 10Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea pig cerebral cortex [AID205267, Type: Literature]
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12
[SID103173276]
IC50 20.893Inhibitory concentration against potassium channel HERG [AID243151, Type: Literature]
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13
[SID103173276]
IC50 20.893Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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14
[SID103173276]
IC50 20.893Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique [AID408340, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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15
[SID103173276]
IC50 20.893Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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16
[SID103173276]
IC50 33.4Cytotoxicity against C57BL/6J mouse splenocytes after 72 hrs by alamar blue assay [AID351891, Type: Literature]
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17
[SID103173276]
IC50 34Inhibition of MBTD1 by alpha-screening [AID537070, Type: Literature]
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18
[SID103173276]
IC50 41Inhibition of L3MBTL1 by alpha-screening [AID537067, Type: Literature]
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19
[SID103173276]
IC50 42Inhibition of L3MBTL3 by alpha-screening [AID537068, Type: Literature]
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20
[SID103173276]
Displacement of [3H](-)-trans-H2-PAT from Guinea pig histamine H2 receptors. [AID88008, Type: Literature]Histamine H2 receptor [gi:1346291]
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