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Digoxin (CID 2724385) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(442)
 
 
Inactive(1195)
 
 
Inconclusive(224)
 
 
Unspecified(314)
 
 
Top Targets:
7TM GPCR Srx(51)
 
 
 
 
7TM GPCR Srsx(42)
 
 
 
 
ABC MTABC3 MD..(40)
 
 
 
NR LBD PPAR(34)
 
 
 
NR LBD ER(27)
 
 
 
 
 
BioAssay Types:
Confirmatory(741)
 
 
 
 
 
Screening(707)
 
 
 
 
Literature(256)
 
 
 
 
 
Summary(63)
 
 
 
 
BioActivity Types:
Potency(638)
 
 
 
 
 
IC50(227)
 
 
 
 
 
EC50(24)
 
 
 
AC50(5)
 
 
 
 
Ki(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1348    Data Row: 2175   Total Pages: 44   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103707689]
Ki 0.0008Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digitoxin as radioligand [AID127357, Type: Literature]
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2
[SID103707689]
Ki 0.0012Binding affinity against Monoclonal antibody mAB-1B3 using [3H]digoxin as radioligand [AID127356, Type: Literature]
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3
[SID103707689]
Kd 0.0031Kinetic parameter against Monoclonal antibody mAB-1B3 [AID127354, Type: other]
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4
[SID144204576]
Potency 0.0035qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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5
[SID144213367]
Potency-Replicate_1 0.0048qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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6
[SID144213367]
Potency-Replicate_1 0.0076qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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7
[SID144213367]
Potency-Replicate_1 0.0122qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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8
[SID144208876]
Potency-Replicate_1 0.0122qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway - cell viability counter screen [AID743203, Type: confirmatory]
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9
[SID144213367]
Potency-Replicate_1 0.0136qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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10
[SID144213367]
Potency-Replicate_1 0.0136qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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11
[SID144213367]
Potency-Replicate_1 0.0136qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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12
[SID144208876]
Potency-Replicate_1 0.0137qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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13
[SID103707689]
IC50 0.0146Cytotoxicity against human TK10 cells after 48 hrs by SRB assay [AID399010, Type: Literature]
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14
[SID144208876]
Potency-Replicate_1 0.0155qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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15
[SID144208876]
Potency-Replicate_1 0.0174qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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16
[SID144208876]
Potency-Replicate_1 0.0195qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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17
[SID144208876]
Potency-Replicate_1 0.0219qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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18
[SID144208876]
Potency-Replicate_1 0.0219qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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19
[SID103707689]
IC50 0.0241Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay [AID399011, Type: Literature]
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20
[SID144208876]
Potency-Replicate_1 0.0246qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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21
[SID144208876]
Potency-Replicate_1 0.0246qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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22
[SID103707689]
IC50 0.0282Cytotoxicity against human K562 cells by XTT assay [AID399014, Type: Literature]
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23
[SID103707689]
IC50 0.0295Cytotoxicity against human UACC62 cells after 48 hrs by SRB assay [AID399012, Type: Literature]
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24
[SID49718191]
EC50 0.03Luminescence Cell-Based HTS Dose Confimation to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID2454, Type: confirmatory]
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25
[SID144213367]
Potency-Replicate_1 0.0303qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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26
[SID144213367]
Potency-Replicate_1 0.0306qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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27
[SID49718191]
EC50 0.034Luminescence Cell-Based Dose Response to Identify Inhibitors of Luciferase Translation or Activity in H4-C Neuroglioblastoma Cells [AID2458, Type: confirmatory]
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28
[SID49718191]
Potency 0.0366qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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29
[SID144213367]
Potency-Replicate_1 0.0385qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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30
[SID103707689]
IC50 0.04Cytotoxicity against human Hs578Bst cells after 72 hrs by CellTiter-Glo assay [AID657872, Type: Literature]
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31
[SID49718191]
EC50 0.04Luminescence Cell-Based Dose Response to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4-C Neuroglioblastoma Cells [AID2452, Type: confirmatory]
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32
[SID144213367]
Potency-Replicate_1 0.0428qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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33
[SID144208876]
Potency-Replicate_1 0.0486qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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34
[SID56422204]
IC50 0.05A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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35
[SID17389540]
Potency 0.0501qHTS assay for cell viability of HEK293 cells [AID743288, Type: confirmatory]
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36
[SID144204576]
Potency-Replicate_1 0.0531qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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37
[SID144208876]
Potency-Replicate_1 0.055qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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38
[SID49718191]
Potency 0.058Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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39
[SID144208876]
Potency-Replicate_1 0.0617qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway [AID743035, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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40
[SID144213367]
Potency-Replicate_1 0.0678qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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41
[SID144213367]
Ratio Potency (uM) 0.0678097qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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42
[SID56422204]
AbsAC35_uM 0.0823HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720588, Type: confirmatory]
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43
[SID144204576]
Potency-Replicate_1 0.0849qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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44
[SID56422204]
AbsAC35_uM 0.0886Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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45
[SID144204576]
Potency-Replicate_1 0.0944qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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46
[SID144208876]
Potency-Replicate_1 0.0978qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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47
[SID103707689]
IC50 0.1Cytotoxicity against human colon cancer cells after 72 hrs by FMCA method [AID471518, Type: Literature]
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48
[SID49718191]
EC50 0.1Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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49
[SID49718191]
EC50 0.1Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
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50
[SID49718191]
EC50 0.1Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
View