9-Aminoacridine hydrochloride monohydrate (CID 2723598) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(345)
 
 
Inactive(478)
 
 
Inconclusive(102)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(18)
 
 
 
TRP 2(10)
 
 
 
7TM GPCR Srsx(8)
 
 
 
G-alpha(6)
 
 
 
NR LBD TR(6)
 
 
 
BioAssay Types:
Confirmatory(348)
 
 
 
 
 
Screening(335)
 
 
 
 
Literature(68)
 
 
 
 
 
BioActivity Types:
Potency(254)
 
 
 
 
 
IC50(35)
 
 
 
 
EC50(11)
 
 
 
AC50(5)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 664    Data Row: 930   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26667397]
EC50 1.163Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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2
[SID17389212]
Potency 2.1331Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID26667397]
Potency 2.3323Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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4
[SID26667397]
Potency 2.3323Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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5
[SID17389212]
Potency 2.3934Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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6
[SID26667397]
AC50 2.48FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]
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7
[SID144204738]
Potency 2.6609qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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8
[SID26667397]
AC50 2.844Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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9
[SID144204738]
Potency 3.3498qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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10
[SID26667397]
AC50 3.63Luminescence Cell-Based Counter Screen to Identify Inhibitors of Cytokine Induced Apoptosis [AID463206, Type: confirmatory]
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11
[SID26667397]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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12
[SID26667397]
EC50 4.83A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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13
[SID26667397]
Potency 5.0119qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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14
[SID26667397]
Potency 5.1735qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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15
[SID17389212]
Potency 7.9433qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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16
[SID17389212]
Potency 7.9433MultiTox-Fluor Cytotoxicity Assay - LYMP1-002 - Dead Cells [AID960, Type: confirmatory]
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17
[SID17389212]
Potency 7.9433Cell Viability - LYMP2-002 [AID977, Type: confirmatory]
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18
[SID26667397]
Potency 7.9433qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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19
[SID26667397]
Potency 7.9433qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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20
[SID17389212]
Potency 9.4392qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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21
[SID17389212]
Potency 10Cell Viability - LYMP2-019 [AID973, Type: confirmatory]
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22
[SID17389212]
Potency 10Cell Viability - LYMP2-009 [AID968, Type: confirmatory]
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23
[SID17389212]
Potency 10Cell Viability - LYMP2-015 [AID971, Type: confirmatory]
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24
[SID17389212]
Potency 10Cell Viability - LYMP2-012 [AID982, Type: confirmatory]
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25
[SID17389212]
Potency 10Cell Viability - LYMP2-014 [AID983, Type: confirmatory]
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26
[SID17389212]
Potency 10Cell Viability - LYMP2-016 [AID984, Type: confirmatory]
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27
[SID17389212]
Potency 10Cell Viability - LYMP2-020 [AID986, Type: confirmatory]
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28
[SID17389212]
Potency 10VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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29
[SID134970488]
CC50 10.35Vero Cytoxicity Assay: A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP) (3) [AID624205, Type: confirmatory]
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30
[SID26667397]
AC50 10.51ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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31
[SID26667397]
EC50 10.558Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
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32
[SID17389212]
Potency 10.5909qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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33
[SID17389212]
Potency 10.5909qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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34
[SID17389212]
Potency 10.5909qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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35
[SID17389212]
Potency 10.5909qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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36
[SID26667397]
Potency 11.2202qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: HTRF assay against cherry picks [AID651804, Type: confirmatory]ERG gene product [Homo sapiens] [gi:343478176]
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37
[SID26667397]
Potency 11.2202qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction: HTRF assay against cherry picks [AID651804, Type: confirmatory]ERG gene product [Homo sapiens] [gi:343478176]
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38
[SID17389212]
Potency 11.2202qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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39
[SID17389212]
Potency 11.2202qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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40
[SID17389212]
Potency 11.2202qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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41
[SID17389212]
Potency 11.2202qHTS assay for small molecule activators of the p53 signaling pathway [AID651743, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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42
[SID17389212]
Potency 11.2202qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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43
[SID17389212]
Potency 11.2202qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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44
[SID17389212]
Potency 12.5893Cell Viability - LYMP2-008 [AID980, Type: confirmatory]
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45
[SID17389212]
Potency 12.5893Cell Viability - LYMP2-010 [AID981, Type: confirmatory]
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46
[SID17389212]
Potency 12.5893Cell Viability - LYMP2-022 [AID987, Type: confirmatory]
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47
[SID17389212]
Potency 12.5893Cell Viability - LYMP2-024 [AID988, Type: confirmatory]
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48
[SID17389212]
Potency 12.5893Cell Viability - LYMP2-018 [AID985, Type: confirmatory]
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49
[SID17389212]
Potency 12.5893Cell Viability - LYMP1-002 - Assay at 40 hr [AID994, Type: confirmatory]
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50
[SID17389212]
Potency 12.5893Cell Viability - LYMP2-001 [AID921, Type: confirmatory]
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