Bookmark and Share
9-Aminoacridine hydrochloride monohydrate (CID 2723598) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(422)
 
 
Inactive(579)
 
 
Inconclusive(202)
 
 
Unspecified(5)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
 
7TM GPCR Srsx(19)
 
 
 
7TM GPCR Srx(18)
 
 
 
NR LBD AR(16)
 
 
 
 
NR LBD ER(16)
 
 
 
BioAssay Types:
Confirmatory(521)
 
 
 
 
 
Screening(392)
 
 
 
 
Literature(68)
 
 
 
 
 
Summary(48)
 
 
 
 
BioActivity Types:
Potency(451)
 
 
 
 
 
IC50(40)
 
 
 
 
EC50(13)
 
 
 
AC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 809    Data Row: 1208   Total Pages: 25   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144207986]
Potency-Replicate_1 0.6768qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View
2
[SID144207986]
Potency-Replicate_1 0.6768qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
3
[SID144204738]
Potency-Replicate_1 0.9439qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
View
4
[SID26667397]
EC50 1.163Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
View
5
[SID144207986]
Potency-Replicate_1 1.9076qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
6
[SID144204738]
Potency-Replicate_1 2.1132qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
7
[SID17389212]
Potency 2.1331Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
8
[SID144207986]
Potency-Replicate_1 2.1404qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
9
[SID144207986]
TR Potency (uM) 2.3111qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
10
[SID26667397]
Potency 2.3323Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
11
[SID26667397]
Potency 2.3323Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
12
[SID17389212]
Potency 2.3934Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
13
[SID144207986]
Potency-Replicate_1 2.4015qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
14
[SID26667397]
AC50_uM 2.48FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
View
15
[SID26667397]
AC50_uM 2.62Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_Dose_CherryPick_Activity [AID743267, Type: confirmatory]cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 [Homo sapiens] [gi:89348172]
View
16
[SID26667397]
AbsAC35_uM 2.63HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Other_Dose_CherryPick_Activity_Set2 [AID743395, Type: confirmatory]
View
17
[SID144204738]
Potency-Replicate_1 2.6603qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
View
18
[SID144204738]
Potency 2.6609qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
19
[SID26667397]
AC50_uM 2.844Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
View
20
[SID144207986]
Ratio Potency (uM) 2.8542qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
View
21
[SID144204738]
Potency-Replicate_1 3.3491qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
View
22
[SID144204738]
Potency 3.3498qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
23
[SID26667397]
EC50 3.374Luminescence-based cell-based high throughput dose response assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID686991, Type: confirmatory]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
View
24
[SID26667397]
AC50_uM 3.63Luminescence Cell-Based Counter Screen to Identify Inhibitors of Cytokine Induced Apoptosis [AID463206, Type: confirmatory]
View
25
[SID170465046]
Potency-Replicate_1 4.216qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
View
26
[SID144204738]
Potency-Replicate_1 4.2163qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
27
[SID144207986]
Potency-Replicate_1 4.2706qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
View
28
[SID144207986]
Potency-Replicate_1 4.2706qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
View
29
[SID144204738]
Ratio Potency (uM) 4.33944qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
View
30
[SID144204738]
TR Potency (uM) 4.38128qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
View
31
[SID26667397]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
32
[SID26667397]
EC50 4.83A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
View
33
[SID26667397]
Potency 5.0119qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
34
[SID26667397]
Potency 5.1735qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
35
[SID144207986]
Potency-Replicate_1 5.4229qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
View
36
[SID144207986]
Potency-Replicate_1 6.0323qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
View
37
[SID170465046]
Potency-Replicate_1 7.4972qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway [AID743220, Type: confirmatory]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
View
38
[SID17389212]
Potency 7.9433qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
View
39
[SID17389212]
Potency 7.9433qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II) [AID886, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
View
40
[SID26667397]
Potency 7.9433qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
41
[SID17389212]
Potency 7.9433Cell Viability - LYMP2-002 [AID977, Type: confirmatory]
View
42
[SID17389212]
Potency 7.9433MultiTox-Fluor Cytotoxicity Assay - LYMP1-002 - Dead Cells [AID960, Type: confirmatory]
View
43
[SID144204738]
AhR Potency (uM) 8.41267qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
44
[SID26667397]
Potency 9.2qHTS for Inhibitors of TGF-b: Confirmation of Cherry Picks [AID720534, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
View
45
[SID144207986]
AhR Potency (uM) 9.3789qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
View
46
[SID17389212]
Potency 9.4392qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
View
47
[SID17389212]
Potency 10Cell Viability - LYMP2-015 [AID971, Type: confirmatory]
View
48
[SID17389212]
Potency 10Cell Viability - LYMP2-009 [AID968, Type: confirmatory]
View
49
[SID17389212]
Potency 10Cell Viability - LYMP2-012 [AID982, Type: confirmatory]
View
50
[SID17389212]
Potency 10Cell Viability - LYMP2-014 [AID983, Type: confirmatory]
View