celecoxib (CID 2662) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(403)
 
 
Inactive(740)
 
 
Inconclusive(138)
 
 
Unspecified(719)
 
 
Top Targets:
prostaglandin..(231)
 
 
 
 
alpha CA I II..(41)
 
 
 
7TM GPCR Srx(31)
 
 
 
 
7TM GPCR Srsx(16)
 
 
 
 
p450(11)
 
 
 
 
BioAssay Types:
Literature(1044)
 
 
 
 
 
Confirmatory(416)
 
 
 
 
 
Screening(337)
 
 
 
 
BioActivity Types:
IC50(451)
 
 
 
 
 
Potency(280)
 
 
 
 
 
Ki(85)
 
 
 
 
EC50(16)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1866    Data Row: 2000   Total Pages: 40   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103181002]
IC50 0.00051Inhibition of LPS-induced COX2 activity in C57BL/6J mouse peritoneal macrophages by RIA [AID379225, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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2
[SID103181002]
IC50 0.00052Inhibition of COX2 [AID362870, Type: Literature]
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3
[SID103181002]
IC50 0.0007Tested for inhibition against Prostaglandin G/H synthase 2 from mouse resident macrophages [AID160561, Type: Literature]
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4
[SID103181002]
EC50 0.00115Inhibition of IL-1beta-induced PGE2 production in human HCA-7 cells after 72 hrs by EIA [AID660183, Type: Literature]
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5
[SID103181002]
IC50 0.002In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells [AID54560, Type: Literature]
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6
[SID103181002]
IC50 0.002Inhibition of PGE-2 production in CHO cells expressing human COX-2. [AID54712, Type: Literature]
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7
[SID103181002]
IC50 0.002In vitro potency against human Prostaglandin G/H synthase 2 in transfected CHO cells. [AID46698, Type: Literature]
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8
[SID103181002]
IC50 0.002Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells. [AID160743, Type: Literature]
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9
[SID103181002]
IC50 0.0022Inhibition of COX2 [AID270014, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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10
[SID103181002]
IC50 0.0037Inhibition of COX1 [AID270013, Type: Literature]
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11
[SID103181002]
IC50 0.006Inhibitory concentration against COX-2 upon incubation for 15 minutes at 37 degree C [AID254882, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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12
[SID103181002]
IC50 0.0068Inhibitory concentration against COX-2; (valus obtained by Kato et al.) [AID254798, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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13
[SID103181002]
IC50 0.0079Inhibitory effect on production of cyclooxygenase-2 (COX-2) prostaglandin E2 (PGE2) in human IL1-beta stimulated synovial cells [AID228024, Type: Literature]
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14
[SID103181002]
IC50 0.0093Tested for inhibition against Prostaglandin G/H synthase 1 from mouse resident macrophages [AID162005, Type: Literature]
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15
[SID103181002]
IC50 0.01Inhibition of human recombinant COX-2 after 2 mins by fluorescence assay [AID592802, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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16
[SID103181002]
IC50 0.016Inhibitory activity against human carbonic anhydrase IX was determined [AID48294, Type: Literature]
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17
[SID103181002]
Ki 0.016Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay [AID369274, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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18
[SID103181002]
Ki 0.016Inhibitory activity against cloned human CA9 [AID258732, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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19
[SID103181002]
IC50 0.016Inhibitory concentration against carbonic anhydrase IX [AID254700, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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20
[SID103181002]
Ki 0.016Inhibition of catalytic domain of human recombinant carbonic anhydrase IX [AID254248, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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21
[SID103181002]
Ki 0.016Inhibition of human recombinant carbonic anhydrase 9 after 15 mins by stopped-flow CO2 hydration assay [AID493891, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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22
[SID103181002]
Ki 0.016Inhibition of human carbonic anhydrase 9-catalyzed CO2 hydration activity by stopped flow assay [AID620687, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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23
[SID103181002]
Ki 0.018Inhibitory activity against cloned human CA12 [AID258733, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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24
[SID103181002]
Ki 0.018Inhibition of human carbonic anhydrase 12-catalyzed CO2 hydration activity by stopped flow assay [AID620688, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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25
[SID103181002]
Ki 0.018Inhibition of human recombinant carbonic anhydrase 12 after 15 mins by stopped-flow CO2 hydration assay [AID493892, Type: Literature]Carbonic anhydrase 12 [gi:5915866]
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26
[SID103181002]
Ki 0.018Inhibition of Brucella suis carbonic anhydrase I by spectrophotometry at pH 8.3 [AID577531, Type: Literature]
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27
[SID103181002]
Ki 0.021Inhibitory activity against cloned human CA2 [AID258730, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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28
[SID103181002]
IC50 0.021Inhibitory concentration against carbonic anhydrase II [AID254699, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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29
[SID103181002]
Ki 0.021Inhibition of cloned human carbonic anhydrase II [AID254247, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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30
[SID103181002]
Ki 0.021Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay [AID349606, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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31
[SID103181002]
Ki 0.021Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay [AID367821, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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32
[SID103181002]
Ki 0.021Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay [AID369272, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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33
[SID103181002]
Ki 0.021Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method [AID414956, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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34
[SID103181002]
Ki 0.021Inhibition of human recombinant CA2 by stopped-flow CO2 assay [AID436564, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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35
[SID103181002]
Ki 0.021Inhibition of human recombinant CA2 by stopped-flow hydration assay [AID437749, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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36
[SID103181002]
Ki 0.021Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay [AID493884, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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37
[SID103181002]
Ki 0.021Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method [AID497129, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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38
[SID103181002]
Ki 0.021Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay [AID644381, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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39
[SID103181002]
Ki 0.021Inhibitory activity against human carbonic anhydrase II (hCAII) [AID238574, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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40
[SID103181002]
Ki 0.021Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay [AID552128, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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41
[SID103181002]
Ki 0.021Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 [AID577527, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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42
[SID103181002]
Ki 0.021Inhibition of human carbonic anhydrase 2-catalyzed CO2 hydration activity by stopped flow assay [AID620686, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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43
[SID103181002]
Ki 0.021Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method [AID669115, Type: Literature]Carbonic anhydrase 2 [gi:115456]
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44
[SID103181002]
IC50 0.021Inhibitory activity of compound against human carbonic anhydrase II [AID47748, Type: Literature]
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45
[SID103181002]
IC50 0.021Inhibitory activity against human carbonic anhydrase II was determined [AID47749, Type: Literature]
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46
[SID103181002]
Ki 0.021Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay [AID427124, Type: Literature]
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47
[SID103181002]
IC50 0.03Inhibition of COX2 by fluorescence assay [AID660182, Type: Literature]
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48
[SID103181002]
IC50 0.03Inhibition of human recombinant COX-2 by fluorescence assay [AID579474, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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49
[SID103181002]
IC50 0.03Inhibition of mouse purified COX2 after 20 mins [AID570437, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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50
[SID103181002]
Ki 0.0342Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay [AID552130, Type: Literature]
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