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BioActivity Data for Compound celecoxib (CID 2662)

BioActivity Outcomes:
Active(580)
 
 
Inactive(985)
 
 
Inconclusive(252)
 
 
Unspecified(1061)
 
 
Top Targets:
prostaglandin..(255)
 
 
 
 
7tm 4(76)
 
 
 
 
alpha CA I II..(37)
 
 
 
NR LBD PPAR(29)
 
 
 
alpha CA(27)
 
 
 
BioAssay Types:
Literature(1397)
 
 
 
 
 
Confirmatory(793)
 
 
 
 
 
Screening(401)
 
 
 
 
Summary(72)
 
 
 
 
BioAssay Categories:
In vitro(234)
 
 
 
 
In vivo(126)
 
 
 
 
Biochemical(1058)
 
 
 
 
 
Toxicity(216)
 
 
 
 
 
ADME(86)
 
 
 
 
Cell-based(422)
 
 
 
 
 
Organism-base..(14)
 
 
 
BioActivity Types:
Potency(576)
 
 
 
 
 
IC50(545)
 
 
 
 
 
Ki(136)
 
 
 
 
EC50(17)
 
 
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 2489    Data Row: 2878   Total Pages: 144   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103181002]
IC50 0.00051Inhibition of LPS-induced COX2 activity in C57BL/6J mouse peritoneal macrophages by RIA [AID379225, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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2
[SID103181002]
IC50 0.00052Inhibition of COX2 [AID362870, Type: Literature]
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3
[SID103181002]
IC50 0.0007Tested for inhibition against Prostaglandin G/H synthase 2 from mouse resident macrophages [AID160561, Type: Literature]
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4
[SID103181002]
EC50 0.00115Inhibition of IL-1beta-induced PGE2 production in human HCA-7 cells after 72 hrs by EIA [AID660183, Type: Literature]
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5
[SID103181002]
IC50 0.002In vitro inhibitory potency against human COX-2 in stably transfected chinese hamster ovary (CHO) cells [AID54560, Type: Literature]
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6
[SID103181002]
IC50 0.002Inhibitory of human Prostaglandin G/H synthase 2 expressed in CHO cells. [AID160743, Type: Literature]
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7
[SID103181002]
IC50 0.002In vitro potency against human Prostaglandin G/H synthase 2 in transfected CHO cells. [AID46698, Type: Literature]
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8
[SID103181002]
IC50 0.002Inhibition of PGE-2 production in CHO cells expressing human COX-2. [AID54712, Type: Literature]
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9
[SID103181002]
IC50 0.0022Inhibition of COX2 [AID270014, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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10
[SID103181002]
IC50 0.0037Inhibition of COX1 [AID270013, Type: Literature]Prostaglandin G/H synthase 1 [gi:754286265]
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11
[SID103181002]
IC50 0.006Inhibitory concentration against COX-2 upon incubation for 15 minutes at 37 degree C [AID254882, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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12
[SID103181002]
IC50 0.0068Inhibitory concentration against COX-2; (valus obtained by Kato et al.) [AID254798, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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13
[SID103181002]
Ki 0.0069Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay [AID743512, Type: Literature]
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14
[SID103181002]
IC50 0.0079Inhibitory effect on production of cyclooxygenase-2 (COX-2) prostaglandin E2 (PGE2) in human IL1-beta stimulated synovial cells [AID228024, Type: Literature]
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15
[SID103181002]
IC50 0.0087Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassay [AID1125683, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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16
[SID103181002]
IC50 0.0093Tested for inhibition against Prostaglandin G/H synthase 1 from mouse resident macrophages [AID162005, Type: Literature]
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17
[SID103181002]
IC50 0.01Inhibition of human recombinant COX-2 after 2 mins by fluorescence assay [AID592802, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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18
[SID103181002]
Ki 0.016Inhibitory activity against cloned human CA9 [AID258732, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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19
[SID103181002]
IC50 0.016Inhibitory concentration against carbonic anhydrase IX [AID254700, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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20
[SID103181002]
Ki 0.016Inhibition of catalytic domain of human recombinant carbonic anhydrase IX [AID254248, Type: Literature]Carbonic anhydrase 9 [gi:83300925]
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