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parbendazole (CID 26596) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(38)
 
 
Inactive(235)
 
 
Inconclusive(55)
 
 
Unspecified(4)
 
 
Top Targets:
p450(11)
 
 
 
 
NR LBD PPAR(8)
 
 
 
NR LBD ER(7)
 
 
 
 
NR LBD AR(7)
 
 
 
 
NR LBD GR(6)
 
 
 
BioAssay Types:
Confirmatory(185)
 
 
 
 
 
Literature(64)
 
 
 
Summary(24)
 
 
 
 
Screening(21)
 
 
 
BioActivity Types:
Potency(170)
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 261    Data Row: 332   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID164339437]
AbsAC35_uM 0.05Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent TC71 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-04_Inhibitor_Dose_DryPowder_Activity [AID743477, Type: confirmatory]
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2
[SID164339437]
AbsAC35_uM 0.05Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_DryPowder_Activity [AID743478, Type: confirmatory]
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3
[SID144204122]
Potency-Replicate_1 0.0507qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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4
[SID144204122]
Potency-Replicate_1 0.0569qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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5
[SID144204122]
Potency 0.057qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID144204122]
Ratio Potency (uM) 0.0620629qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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7
[SID144204122]
Potency 0.0718qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID144204122]
Potency-Replicate_1 0.0804qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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9
[SID144204122]
Potency-Replicate_1 0.0902qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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10
[SID144204122]
Potency-Replicate_1 0.1012qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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11
[SID144204122]
Potency-Replicate_1 0.1136qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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12
[SID144204122]
Potency-Replicate_1 0.1136qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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13
[SID11112614]
Potency 0.1276A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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14
[SID11112614]
Potency 0.2389S16 Schwann cell PMP22 intronic element beta-lactamase assay [AID624044, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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15
[SID144204122]
Potency-Replicate_1 0.2543qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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16
[SID144204122]
Ratio Potency (uM) 0.603021qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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17
[SID144204122]
Potency-Replicate_1 0.8041qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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18
[SID144204122]
ATAD5 Potency (uM) 0.902261qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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19
[SID144204122]
Potency-Replicate_1 1.0124qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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20
[SID144204122]
AhR Potency (uM) 1.09311qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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21
[SID144204122]
Potency-Replicate_1 2.2664qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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22
[SID144204122]
Ratio Potency (uM) 3.53852qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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23
[SID144204122]
Potency-Replicate_1 5.0738qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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24
[SID170466402]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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25
[SID11112614]
GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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26
[SID11112614]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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27
[SID11112614]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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28
[SID85860907]
Inhibition of P. falciparum 3D7 [AID2306, Type: screening]L-lactate dehydrogenase [Plasmodium falciparum 3D7] [gi:124513266]
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29
[SID85788909]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of STK33 [AID2330, Type: screening]serine/threonine kinase 33 [Homo sapiens] [gi:12830367]
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30
[SID85788909]
Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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31
[SID11112614]
Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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32
[SID11112614]
qHTS Assay for Spectroscopic Profiling in 4-MU Spectral Region [AID589, Type: other]
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33
[SID11112614]
qHTS Assay for Spectroscopic Profiling in A350 Spectral Region [AID590, Type: other]
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34
[SID138433]
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID328, Type: other]
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35
[SID138433]
NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice [AID256, Type: other]
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36
[SID138433]
NCI In Vivo Anticancer Drug Screen. Data for tumor model B16 Melanoma (intraperitoneal) in B6C3F1 mice [AID200, Type: other]
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37
[SID138433]
NCI In Vivo Anticancer Drug Screen. Data for tumor model Mammary Adenocarcinoma CD8F1 (subcutaneous) in CD8F1 [AID220, Type: other]
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38
[SID138433]
NCI In Vivo Anticancer Drug Screen. Data for tumor model L1210 Leukemia (intraperitoneal) in B6D2F1 (BDF1) mice [AID248, Type: other]
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39
[SID85860907]
XC50_3D7 0.68XC50 for P. falciparum 3D7 [AID2305, Type: confirmatory]
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40
[SID11112614]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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41
[SID85860907]
Inhibition Frequency Index [AID2297, Type: other]
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42
[SID11112614]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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43
[SID124882476]
Potency 0.0013qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743345, Type: confirmatory]
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44
[SID144204122]
Potency-Replicate_1 0.0127qHTS assay for small molecule agonists of the p53 signaling pathway - cell viability [AID651633, Type: confirmatory]
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45
[SID11112614]
Potency 0.1qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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46
[SID144204122]
Potency-Replicate_1 0.9023qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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47
[SID11112614]
Potency 1.0182Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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48
[SID11112614]
Potency 1.5472S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]peripheral myelin protein 22 [Rattus norvegicus] [gi:8393992]
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49
[SID11112614]
Potency 1.8106Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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50
[SID144204122]
Potency-Replicate_1 4.522qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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