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7-bromo-6-methoxyquinoline-5,8-dione (CID 265935) - Compound BioActivity Data
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BioActivity Outcomes:
Active(64)
 
 
Inactive(239)
 
 
Inconclusive(25)
 
 
Unspecified(5)
 
 
Top Targets:
7TM GPCR Srx(13)
 
 
 
7TM GPCR Srsx(11)
 
 
 
PP1c bdg(6)
 
 
 
 
Hexokinase 2(6)
 
 
 
PAD(5)
 
 
 
BioAssay Types:
Screening(213)
 
 
 
 
Confirmatory(101)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(77)
 
 
 
 
 
IC50(22)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 285    Data Row: 333   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92764075]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID92764075]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID92764075]
Potency 0.8913Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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4
[SID92764075]
Potency 1.2589qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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5
[SID92764075]
Potency 1.8888qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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6
[SID92764075]
Potency 2.9093A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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7
[SID92764075]
Potency 3.1623qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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8
[SID92764075]
IC50 3.41Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocysteine [gi:219689243]
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9
[SID92764075]
IC50_Mean 3.53Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. [AID504756, Type: confirmatory]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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10
[SID92764075]
Potency 3.5481Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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11
[SID92764075]
IC50_Mean 3.56Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) [AID504729, Type: confirmatory]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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12
[SID92764075]
IC50_Mean 4.89Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) in the hexokinase 1 selectivity assay [AID504763, Type: confirmatory]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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13
[SID92764075]
Potency 5.1735A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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14
[SID92764075]
Potency 6.3096qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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15
[SID92764075]
Potency 8.1995qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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16
[SID92764075]
Potency 8.9125qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen [AID720708, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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17
[SID92764075]
Potency 10qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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18
[SID92764075]
Potency 10HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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19
[SID92764075]
Potency 11.2202qHTS for Inhibitors of Vif-A3F Interactions: qHTS [AID602313, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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20
[SID92764075]
Potency 15.8489qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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21
[SID92764075]
Potency 23.7781qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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22
[SID92764075]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1B, catalytic subunit 3 (PAFAH1B3) [AID492972, Type: screening]platelet-activating factor acetylhydrolase IB subunit gamma [Homo sapiens] [gi:225543099]
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23
[SID92764075]
uHTS Fluorescent Assay Using Nedd8 Protein Substrate for Identification of Inhibitors of Sentrin-Specific Protease 8 (SENP8) [AID602440, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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24
[SID92764075]
uHTS Fluorescent assay for identification of inhibitors of hexokinase domain containing I (HKDC1) [AID493160, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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25
[SID92764075]
Single concentration confirmation of inhibitors of hexokinase domain containing I (HKDC1) [AID504710, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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26
[SID92764075]
uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin-1 [gi:160877737]
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27
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to identify inhibitors of PAD4 [AID588559, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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28
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PAD4 [AID651627, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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29
[SID92764075]
Fluorescence polarization-based biochemical primary high throughput screening assay to identify inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID624377, Type: screening]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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30
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628, Type: other]
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31
[SID92764075]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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32
[SID92764075]
uHTS Identification of Diaphorase Inhibitors and Chemical Oxidizers: Counter Screen for the uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay in the presence of 10 uM NADPH [AID504862, Type: screening]
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33
[SID92764075]
uHTS Identification of Diaphorase Inhibitors and Chemical Oxidizers: Counter Screen for the uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay in the presence of 30 uM NADPH [AID504863, Type: screening]
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34
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_1, Type: other]
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35
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_2, Type: other]
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36
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_3, Type: other]
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37
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_4, Type: other]
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38
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560, Type: other]
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39
[SID92764075]
IC50_PEG-3_Mean Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_7, Type: confirmatory]
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40
[SID92764075]
Fluorescence-based biochemical high throughput screening primary assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID651958, Type: screening]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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41
[SID92764075]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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42
[SID92764075]
Single concentration confirmation of uHTS hits for Peg3 Promoter Inhibitors via a luciferase reporter assay [AID602417, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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43
[SID92764075]
IC50_PEG-3_Mean Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_4, Type: confirmatory]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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44
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_1, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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45
[SID118043670]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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46
[SID92764075]
uHTS fluorescent assay for identification of inhibitors of ATG4B [AID504462, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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47
[SID92764075]
uHTS identification of antagonists of the CRF-binding protein and CRF-R2 receptor complex [AID588475, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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48
[SID92764075]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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49
[SID92764075]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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50
[SID92764075]
uHTS identification of SUMO1-mediated protein-protein interactions [AID602429, Type: screening]SUMO-1 [Homo sapiens] [gi:1762973]
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