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Butyric Acid (CID 264) - Compound BioActivity Data
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BioActivity Outcomes:
Active(14)
 
 
Inactive(173)
 
 
Inconclusive(18)
 
 
Unspecified(42)
 
 
Top Targets:
NR LBD PPAR(16)
 
 
 
NR LBD ER(14)
 
 
 
NR LBD AR(14)
 
 
 
NR LBD VDR(8)
 
 
 
NR LBD GR(8)
 
 
BioAssay Types:
Confirmatory(124)
 
 
 
Literature(57)
 
 
 
 
Summary(48)
 
 
 
BioActivity Types:
Potency(160)
 
 
 
IC50(20)
 
 
 
Ki(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 158    Data Row: 247   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176198]
IC50 9Inhibition of human recombinant HDAC3 [AID569930, Type: Literature]Histone deacetylase 3 [gi:3334210]
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2
[SID103176198]
IC50 12Inhibition of human recombinant HDAC2 [AID569929, Type: Literature]Histone deacetylase 2 [gi:68068066]
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3
[SID103176198]
IC50 15Inhibition of human recombinant HDAC8 [AID569931, Type: Literature]Histone deacetylase 8 [gi:29839394]
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4
[SID103176198]
IC50 16Inhibition of human recombinant HDAC1 [AID569928, Type: Literature]Histone deacetylase 1 [gi:2498443]
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5
[SID46393305]
Ki 1300Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Co-Type Nitrile Hydratase Complexed With N-Butyric Acid [gi:50513824]
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6
[SID46393305]
Ki 1300Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Crystal Structure Of Co-Type Nitrile Hydratase Complexed With N-Butyric Acid [gi:50513824]
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7
[SID46393305]
Ki 1300Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain B, Crystal Structure Of Co-Type Nitrile Hydratase Complexed With N-Butyric Acid [gi:50513825]
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8
[SID46393305]
Ki 1300Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain B, Crystal Structure Of Co-Type Nitrile Hydratase Complexed With N-Butyric Acid [gi:50513825]
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9
[SID74110]
NCI In Vivo Anticancer Drug Screen. Data for tumor model Mammary Adenocarcinoma CD8F1 (subcutaneous) in CD8F1 [AID220, Type: other]
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10
[SID103176198]
Inhibition of 26S proteasome activity in human U251 cells at 0.5 mM after 24 hrs [AID347410, Type: Literature]
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11
[SID103176198]
Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in p21 mRNA level by qRT-PCR [AID412897, Type: Literature]
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12
[SID103176198]
Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in histone H3 acetylation after 3 days by densitometry [AID412899, Type: Literature]
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13
[SID103176198]
Increase in ROS production in human U251 cells at 100 uM after 4 hrs by FACS [AID347396, Type: Literature]
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14
[SID103176198]
Increase in ROS production in human U251 cells at 100 uM after 4 hrs by FACS in presence of N-acetyl-L-cysteine [AID347397, Type: Literature]
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15
[SID103176198]
Ki 81.2831Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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16
[SID103176198]
IC50 250Concentration required to inhibit the colony formation of pancreatic human (PACA) cell lines by 50% [AID154429, Type: Literature]
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17
[SID103176198]
ED50 285In vitro for the differentiation induction activity determined in the human myeloid leukemic cell line HL-60 [AID81291, Type: Literature]
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18
[SID103176198]
IC50 850Concentration required for 50% proliferation inhibition of myelomonocytic WEHI cell line [AID217956, Type: Literature]
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19
[SID103176198]
IC50 932Cytotoxicity against human U251 cells after 72 hrs by Hoechst test [AID347392, Type: Literature]
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20
[SID103176198]
IC50 933Inhibitory activity on growth of B16F10.9 melanoma cell line [AID41062, Type: Literature]
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