Butyric Acid (CID 264) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(16)
 
 
Inconclusive(3)
 
 
Unspecified(42)
 
 
Top Targets:
GT1 Gtf like(2)
 
 
HDAC6-dom1(2)
 
 
 
MFS(2)
 
 
HDAC1(1)
 
 
HDAC2(1)
 
 
BioAssay Types:
Literature(50)
 
 
 
 
BioActivity Types:
IC50(20)
 
 
 
Ki(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 71    Data Row: 71   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176198]
IC50 9Inhibition of human recombinant HDAC3 [AID569930, Type: Literature]Histone deacetylase 3 [gi:3334210]
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2
[SID103176198]
IC50 9Inhibition of human recombinant HDAC3 [AID569930, Type: Literature]Histone deacetylase 3 [gi:3334210]
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3
[SID103176198]
IC50 12Inhibition of human recombinant HDAC2 [AID569929, Type: Literature]Histone deacetylase 2 [gi:68068066]
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4
[SID103176198]
IC50 15Inhibition of human recombinant HDAC8 [AID569931, Type: Literature]Histone deacetylase 8 [gi:29839394]
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5
[SID103176198]
IC50 16Inhibition of human recombinant HDAC1 [AID569928, Type: Literature]Histone deacetylase 1 [gi:2498443]
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6
[SID103176198]
 Increase in ROS production in human U251 cells at 100 uM after 4 hrs by FACS [AID347396, Type: Literature]
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7
[SID103176198]
 Increase in ROS production in human U251 cells at 100 uM after 4 hrs by FACS in presence of N-acetyl-L-cysteine [AID347397, Type: Literature]
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8
[SID103176198]
 Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in p21 mRNA level by qRT-PCR [AID412897, Type: Literature]
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9
[SID103176198]
 Inhibition of HDAC in human MDA-MB-231 cells assessed as increase in histone H3 acetylation after 3 days by densitometry [AID412899, Type: Literature]
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10
[SID74110]
 NCI In Vivo Anticancer Drug Screen. Data for tumor model Mammary Adenocarcinoma CD8F1 (subcutaneous) in CD8F1 [AID220, Type: other]
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11
[SID103176198]
 Inhibition of 26S proteasome activity in human U251 cells at 0.5 mM after 24 hrs [AID347410, Type: Literature]
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12
[SID103176198]
Ki 81.283Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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13
[SID103176198]
IC50 250Concentration required to inhibit the colony formation of pancreatic human (PACA) cell lines by 50% [AID154429, Type: Literature]
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14
[SID103176198]
ED50 285In vitro for the differentiation induction activity determined in the human myeloid leukemic cell line HL-60 [AID81291, Type: Literature]
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15
[SID103176198]
IC50 850Concentration required for 50% proliferation inhibition of myelomonocytic WEHI cell line [AID217956, Type: Literature]
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16
[SID103176198]
IC50 932Cytotoxicity against human U251 cells after 72 hrs by Hoechst test [AID347392, Type: Literature]
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17
[SID103176198]
IC50 933Inhibitory activity on growth of B16F10.9 melanoma cell line [AID41062, Type: Literature]
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18
[SID103176198]
IC50 1000Concentration required to inhibit the colony formation of lung carcinoma (3LLD122) cell lines by 50% [AID3329, Type: Literature]
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19
[SID103176198]
IC50 1525Concentration required for 50% proliferation inhibition of human promyelocytic HL-60 cell line [AID81447, Type: Literature]
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20
[SID103176198]
IC50 2000Inhibition of human recombinant HDAC7 [AID569934, Type: Literature]Histone deacetylase 7 [gi:30913097]
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21
[SID103176198]
IC50 2000Inhibition of human recombinant HDAC5 [AID569933, Type: Literature]Histone deacetylase 5 [gi:296434519]
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22
[SID103176198]
IC50 2000Antiproliferative activity against human K562 cells [AID416474, Type: Literature]
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23
[SID103176198]
IC50 2000Inhibition of human recombinant HDAC9 [AID569935, Type: Literature]Histone deacetylase 9 [gi:19865267]
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24
[SID103176198]
IC50 2000Inhibition of human recombinant HDAC4 [AID569932, Type: Literature]Histone deacetylase 4 [gi:259016348]
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25
[SID103176198]
IC50 2000Inhibition of human recombinant HDAC6 [AID569936, Type: Literature]Histone deacetylase 6 [gi:205371758]
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26
[SID103176198]
IC50 2400Inhibition of cell growth against human myeloid leukemia K562(S) cells [AID95143, Type: Literature]
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27
[SID103176198]
Ki 3467.37Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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28
[SID103176198]
IC50 10000Inhibition of 2-oxoglutarate-dependent human JMJD2E in presence of excess 2-oxoglutarate and 10 uM Fe2 by FDH coupled assay [AID344916, Type: Literature]
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29
[SID103176198]
IC50 10000Inhibition of 2-oxoglutarate-dependent human JMJD2E in prescence of excess H3K9me3 peptide and 10 uM Fe2 by FDH coupled assay [AID344917, Type: Literature]
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30
[SID103176198]
 Inhibition of 26S proteasome activity in human U251 cells at 100 uM after 48 hrs relative to control [AID347412, Type: Literature]
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31
[SID103176198]
 Inhibition of 26S proteasome activity in human U251 cells at 100 uM after 48 hrs in presence of N-acetyl-L-cysteine relative to control [AID347413, Type: Literature]
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32
[SID103176198]
 Ratio of pKi for mouse Oat1 expressed in Xenopus oocytes to pKi for mouse Oat6 expressed in Xenopus oocytes [AID360151, Type: Literature]
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33
[SID103176198]
 Inhibition of erythroid differentiation in human K562 cell assessed benzidine positive cells at 2 mM after 6 days by benzidine staining assay [AID410585, Type: Literature]
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34
[SID103176198]
 Protein interaction energy by using binding affinity towards human L-xylulose reductase enzyme [AID95754, Type: Literature]
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35
[SID103176198]
 Evaluated for erythroid induction of benzidine-positive K562 cells at concentration 3 mM [AID94965, Type: Literature]
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36
[SID103176198]
 Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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37
[SID103176198]
 Inhibition of EBV-early antigen activation in human Raji cells assessed as early antigen activation at 4 mM [AID336938, Type: other]
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38
[SID103176198]
 Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation at 4 mM ratio relative to TPA [AID336939, Type: other]
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39
[SID103176198]
 Partition coefficient (logP) (chloroform) [AID23254, Type: Literature]
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40
[SID103176198]
 Partition coefficient (logP) (ether) [AID23255, Type: Literature]
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41
[SID103176198]
 Partition coefficient (logP) (hexane) [AID23256, Type: Literature]
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42
[SID103176198]
 Effect on appearance of B16F10.9 colonies in semisolid agar at 1 mM [AID41060, Type: Literature]
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43
[SID103176198]
 TP_TRANSPORTER: uptake of Butyric acid at a concentration of 137uM in MCT1-expressing MDA-MB231 cells [AID682070, Type: other]Monocarboxylate transporter 1 [gi:1709076]
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44
[SID103176198]
 Specific activity of expressed human recombinant UGT1A10 [AID624613, Type: Literature]UDP-glucuronosyltransferase 1-10 [gi:29839636]
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45
[SID103176198]
 Specific activity of expressed human recombinant UGT1A8 [AID624611, Type: Literature]UDP-glucuronosyltransferase 1-8 [gi:29839637]
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46
[SID103176198]
 Increase in heme level in human U251 cells at 100 uM after 48 hrs by western blot relative to control [AID347403, Type: Literature]
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47
[SID103176198]
 Toxicity in po dosed rat [AID498776, Type: Literature]
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48
[SID103176198]
 Toxicity in po dosed ICR mouse assessed as decreased in mobility after 3 hrs [AID498773, Type: Literature]
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49
[SID103176198]
 Induction of erythroid differentiation in human K562 cells assessed as benzidine-positive cells after 6 days [AID416475, Type: Literature]
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50
[SID103176198]
 Partition coefficient (logP) [AID23251, Type: Literature]
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